A5100669572- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- MRI in cancer diagnosis
- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Synthesis and biological activity
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Trigeminal Neuralgia and Treatments
- Renal cell carcinoma treatment
- Cardiovascular Issues in Pregnancy
- Infrared Thermography in Medicine
- Genomics, phytochemicals, and oxidative stress
- Animal Virus Infections Studies
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Hepatitis B Virus Studies
- Magnolia and Illicium research
- Advanced Neuroimaging Techniques and Applications
- Plant-derived Lignans Synthesis and Bioactivity
- Spinal Cord Injury Research
- Advanced NMR Techniques and Applications
Sejong Institute
2023
Sir Run Run Shaw Hospital
2004-2021
Zhejiang University
2004-2021
Purpose To evaluate the possibility of using a variable flip angle (VFA) T 1 mapping technique to diagnose liver fibrosis. Materials and Methods Liver fibrosis was induced in rabbits by repetitive administration carbon tetrachloride (CCl 4 ). ‐weighted magnetic resonance imaging (MRI) performed 29 animals (liver fibrosis, n = 18; control, 11) series nonenhanced acquisition volume acceleration (LAVA) with VFAs at 3.0T. Hepatic relaxation times were measured via regions interest, which...
α-Amino acid N-thiocarboxyanhydrides (NTAs) are promising cyclic monomers to synthesize polypeptides and polypeptoids via controlled ring-opening polymerizations. Superior N-carboxyanhydrides requiring protection on hydroxyl groups, NTAs able tolerate such nucleophiles. In this work, we report the synthesis of NTA containing unprotected phenolic groups 3,4-dihydroxy-l-phenylalanine (DOPA) l-tyrosine (Tyr). Their ROPs sequential copolymerizations with polysarcosine (PSar) yield PDOPA, PTyr,...
Magnetic resonance (MR) contrast agents focusing on special functions are required to improve cancer diagnosis, particularly in the early stages. Here, we designed multifunctional solid lipid nanoparticles (SLNs) with simultaneous loading of gadolinium (Gd) diethylenetriaminepentaacetic acid (Gd-DTPA) and octadecylamine fluorescein isothiocyanate (FITC) obtain Gd-FITC-SLNs as a tumor-absorbable nanoparticle agent for histological confirmation MR imaging (MRI) findings. Colorectal tumors were...
Purpose To evaluate the pharmacokinetic parameters of dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) in diagnosing and staging liver fibrosis rabbits. Materials Methods DCE‐MRI with gadodiamide (Gd‐DTPA‐BMA) was performed on a 3.0 Tesla, 60 cm bore MR scanner for rabbits CCl 4 ‐induced fibrosis, an untreated control group. Fibrosis staged according to METAVIR system: (F0; n = 13), nonadvanced (F1–2; 15), advanced (F3–4; 12). The K trans , k ep V e v p were measured dual‐input...
Breast cancer is the most common malignancy in women worldwide. Recent developments minimally invasive interventional radiology techniques have significantly improved breast treatment. This study aimed to develop a novel technique for local management of cancers using radiofrequency heat (RFH). We performed both vitro experiments human cells and vivo validation xenograft animal models with magnetic resonance imaging (MRI) pathological correlation investigate feasibility our approach. Four...
Europium (Eu) is a paramagnetic lanthanide element that possesses an outstanding luminescent property. Eu complexes are ideal fluorescence imaging (FI) agents. Eu2+ has satisfactory relaxivity and optical properties, can realize magnetic resonance (MRI)-FI dual applications when used with appropriate cryptands render it oxidatively stable. By contrast, based on the chemical exchange saturation transfer (CEST) mechanism, Eu3+ provide enhanced MRI sensitivity optimal cryptands, incorporated...
Neurovascular compression (NVC) of the trigeminal nerve is associated with neuralgia (TN). Some arteries that compress are large, while others small. This study evaluated influence diameter (DCA) on NVC and without TN using axial diffusivity (AD) radial (RD) magnetic resonance (MR) imaging. Fifty patients unilateral NVC, 50 asymptomatic healthy controls (HC) were divided into three groups (NVC TN, HC). The imaged a 3.0-T MR system three-dimensional fast imaging employing steady-state...
Gene therapy is a frontier in modern medicine. In the present study, we explored new technique for effective treatment of multidrug-resistant (MDR) breast cancer by combining fully advantages multidisciplinary fields, including image-guided minimally invasive interventional oncology, radiofrequency technology, and direct intratumoral gene therapy.Combination with PHSP-TK plus RFH resulted significantly higher TK transfection/expression, as well lower cell proliferation rate apoptosis index,...
A novel, minimally invasive interventional technique, radiofrequency heat (RFH), has been suggested to improve the efficacy of chemotherapy for solid organ tumors. However, treatment prostate cancer not completely characterized. The aim present study was investigate in vitro and vivo efficiency combination with RFH cancer. following four groups were included: i) No (control); ii) RFH‑only; iii) (docetaxel)‑only; iv) therapy docetaxel human (HPC) cell lines mice HPC xenografts. In...
Objectives:We aim to compare the fetal growth and birthweight between women with without placenta accreta spectrum (PAS) uncomplicated pregnancies.Methods: Estimated weight (EFW) (BW) were evaluated in 155 PAS, 154 PAS matched by body mass index (BMI) gestational age (GA) at delivery, a normal control group of 17,301 patients.EFWs obtained during pregnancy from 3 groups plotted against weeks.EFW trends using regression analyses, after log transformation BW, intercept, slopes linear quadratic...
Purpose To evaluate the performance of diffusion-weighted imaging (DWI) and variable flip angle (VFA) T1 mapping as a supplement to image-guided biopsy in follow-up analysis liver fibrosis. Materials Methods This prospective study was approved by institution's committee on human research, written informed consent provided from enrolled patients. We investigated five MRI parameters DWI VFA mapping, collected 11 patients who underwent serial ultrasound with within 1.5 years after treatment for...
This study was aimed to investigate the diagnostic accuracy of magnetic resonance imaging (MRI) based on deep dictionary learning in TNM (tumor, node, and metastasis) staging renal cell carcinoma. In this study, 82 patients with cancer were selected as research object. The results diagnosed by MRI, performed professional personnel. MRI image will be reconstructed after improve its recognition ability. pathological diagnosis handed over physiological pathology laboratory hospital for...