A5088117004- Multiple Sclerosis Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Mycobacterium research and diagnosis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Plant Pathogens and Resistance
- Skin and Cellular Biology Research
- Medicine and Dermatology Studies History
- Genetic Mapping and Diversity in Plants and Animals
- Powdery Mildew Fungal Diseases
- RNA regulation and disease
- Peripheral Neuropathies and Disorders
- T-cell and Retrovirus Studies
- Colorectal Cancer Screening and Detection
- Cytokine Signaling Pathways and Interactions
- Plant Virus Research Studies
- T-cell and B-cell Immunology
- Body Image and Dysmorphia Studies
- Plant Disease Resistance and Genetics
- Intracranial Aneurysms: Treatment and Complications
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Wheat and Barley Genetics and Pathology
- RNA Research and Splicing
Karolinska Institutet
2019-2024
Kolding Hospital
2021-2024
Lillebaelt Hospital
2020
Karolinska University Hospital
2019
Odense University Hospital
2015-2019
Instituto de Neurologia Y Neurocirugia
2018
Sygehus Sønderjylland
2009-2015
University of Southern Denmark
2014-2015
Brighton and Sussex Medical School
2009-2010
Depression is common in multiple sclerosis (MS), but its impact on disability worsening has not yet been determined. We explored the risk of associated with depression a nationwide longitudinal cohort.This retrospective cohort study used linked data from 3 Swedish registries: MS Register, National Patient and Prescribed Drug Register. Two incident cohorts were developed: 1 included all registered cases Registry (2001-2014) defined as ≥1 ICD-10 code for depression; 2 comprised (2005-2014)...
Background: Large population-based genome-wide association studies have identified several multiple sclerosis (MS) genetic risk variants, but the existing missing heritability warrants different strategies. Isolated populations offer an alternative way of searching for rare variants and evaluating possible role consanguinity in development MS. Studies MS yielded conflicting results. Objectives: In this study we investigated on relatively isolated Faroe Islands, which a presumed high level...
To establish the validity of intracerebral hemorrhage (ICH) diagnoses in Danish Stroke Registry (DSR) and National Patient (DNPR).Based on discharge summaries brain imaging reports, we estimated positive predictive value (PPV) a first-ever diagnosis code for ICH (ICD-10, I61) all patients Region Southern Denmark (1.2 million) during 2009-2017 according to either DNPR or DSR. We PPVs any non-traumatic (a-ICH) spontaneous (s-ICH) alone (ie, without underlying structural cause). also calculated...
Depression is common in multiple sclerosis (MS); however, the underlying mechanism for relationship remains unknown. In this study, we examined a putative causal between depression and MS using bidirectional Mendelian randomisation (MR) framework. Using latest genome-wide association study data available, 168 non-major histocompatibility complex (MHC) independent variants associated with 96 genetic susceptibility were used. Maximum likelihood, weighted median, inverse variance method...
Functional neurological disorder (FND) is a common cause of disability. Despite recent advances in pathophysiological understanding and treatments, application this knowledge to clinical practice variable limited.
In search of the missing heritability in multiple sclerosis (MS), additional approaches adding to genetic discoveries large genome-wide association studies are warranted.The objective this research paper is for rare MS risk variants genetically homogenous population isolated Faroe Islands.Twenty-nine Faroese cases and 28 controls were genotyped with HumanOmniExpressExome-chip. The individuals make up 1596 pair-combinations which we searched identical-by-descent shared segments using...
John Kurtzke has proposed that multiple sclerosis (MS) on the Faroe Islands occurred as a result of spread transmittable agent brought to country during World War II.Kurtzke's theory been opposed earlier and in this study, we present family from containing total 14 members with MS which show further inconsistencies theory. The study is our knowledge, first description familial incidences Islands.Medical histories were gathered 12 6 8 living cases human leukocyte antigen (HLA)-typed.Seven had...
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Few studies have examined the effect of concomitant autoimmune diseases on multiple sclerosis (MS) disability worsening. We set out to examine whether Crohn's Disease (CD), Ulcerative Colitis (UC), or Type 1 Diabetes (T1D) affect MS worsening in a nationwide cohort patients as defined by reaching expanded scale status (EDSS) scores 3.0, 4.0 and 6.0. Patients with onset between January 2004 2019 were identified from Swedish registry National Patient Register. Kaplan-Meier analysis was used...
OBJECTIVE: In this study we performed a segmental sharing analysis of multiple sclerosis (MS) cases and controls in order to identify segments shared more frequently among case-pairs than control-pairs, which may suggest presence MS risk loci. BACKGROUND: Studies have shown that heritability might be as high 70[percnt]. So far approximately 30[percnt] the has been accounted for. Isolated populations studies offer an alternative large-scale genome wide association search for missing...
OBJECTIVE: In this study we investigated the role of consanguinity on MS risk in relatively isolated Faroe Islands, which have presumed high level inbreeding. BACKGROUND:Large population based genome-wide-association-studies identified several multiple sclerosis (MS) genetic variants, but existing missing heritability warrants different strategies. Isolated populations offer an alternative way searching for rare variants and evaluating possible development MS. Studies yielded conflicting...