A5001878258- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Obsessive-Compulsive Spectrum Disorders
- Genetic Neurodegenerative Diseases
- Mental Health and Psychiatry
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Glycogen Storage Diseases and Myoclonus
- Body Image and Dysmorphia Studies
- Neurology and Historical Studies
- Neurological and metabolic disorders
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Restless Legs Syndrome Research
- Dementia and Cognitive Impairment Research
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Mental Health Research Topics
- Neuroethics, Human Enhancement, Biomedical Innovations
- Long-Term Effects of COVID-19
- Genetics and Neurodevelopmental Disorders
Amsterdam University Medical Centers
2021-2024
Vrije Universiteit Amsterdam
2021-2024
University Medical Center Groningen
2014-2023
University of Groningen
2014-2023
University of Amsterdam
2011-2022
Amsterdam Neuroscience
2022
University of Edinburgh
2013-2020
St George's, University of London
2020
Fonds Psychische Gezondheid
2020
Cardiff University
2018
Abstract Reliable data on the prognosis of functional motor disorder are scarce, as existing studies nearly all retrospective, small and uncontrolled. In this study we used a prospectively recruited, controlled cohort design to assess misdiagnosis, mortality symptomatic health outcome in patients with limb weakness compared neurological disease healthy control subjects. We also carried out an exploratory analysis for baseline factors predicting outcome. One hundred seven weakness, 46 38...
<h3>Objective</h3> To determine the contribution of electrophysiologic testing in diagnosis and anatomical classification myoclonus. <h3>Methods</h3> Participants with a clinical myoclonus were prospectively recruited, each undergoing videotaped examination battery tests. The its subtype was reviewed after 6 months context findings specialist review examination. <h3>Results</h3> Seventy-two patients recruited. Initial included 25 cortical myoclonus, 7 subcortical 2 spinal 15 functional...
North Sea Progressive Myoclonus Epilepsy is a rare and severe disorder caused by mutations in the GOSR2 gene. It clinically characterized progressive myoclonus, seizures, early-onset ataxia areflexia. As other myoclonus epilepsies, efficacy of antiepileptic drugs disappointingly limited Epilepsy. The ketogenic diet less restrictive modified Atkins have been proven to be effective drug-resistant epilepsy syndromes, including those with myoclonic seizures. Our aim was evaluate patients...
Functional neurological disorder (FND) is a common and disabling condition at the intersection of neurology psychiatry. Despite remarkable progress over recent decades, mechanisms FND are still poorly understood there limited diagnostic tools effective treatments. One potentially promising treatment modality for virtual reality (VR), which has been increasingly applied to broad range conditions, including neuropsychiatric disorders. unique features, many suggest particular relevance for,...
Objective To study the effect of botulinum neurotoxin (BoNT) treatment in jerky and tremulous functional movement disorders (FMD). Methods Patients with invalidating, chronic (>1 year) symptoms were randomly assigned to two subsequent treatments BoNT or placebo every 3 months stratification according symptom localisation. Improvement on dichotomised Clinical Global Impression-Improvement scale (CGI-I) (improvement vs no change worsening) at 4 months, assessed by investigators blinded...
To determine whether self-rated health of patients with motor functional neurologic disorder (FND) can be improved by unguided Internet-based self-help and education.In this nonblinded randomized controlled trial, were allocated 1:1 unbiased to an education website in addition usual care or only. Patients over 17 years age a symptom that caused distress disability included. The primary outcome was on the Clinical Global Improvement scale at 3 6 months. Secondary outcomes severity symptoms,...
Functional neurological disorder (FND) is a common cause of disability. Despite recent advances in pathophysiological understanding and treatments, application this knowledge to clinical practice variable limited.
This exploratory study set out to investigate dynamic functional connectivity (dFC) in patients with jerky and tremulous movement disorders (JT-FMD). The focus this work is on brain states, which represent distinct dFC patterns that reoccur time across subjects. Resting-state fMRI data were collected from 17 JT-FMD healthy controls (HC). Symptom severity was measured using the Clinical Global Impression-Severity scale. Depression anxiety Beck Inventory (BDI) Anxiety (BAI), respectively....
Functional neurological disorder (FND) is a common and disabling condition at the intersection of neurology psychiatry. Despite remarkable progress over recent decades, mechanisms FND are still poorly understood there limited diagnostic tools effective treatments. One potentially promising treatment modality for virtual reality (VR), which has been increasingly applied to broad range conditions, including neuropsychiatric disorders. unique features, many suggest particular relevance for,...
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