A5013376335- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Glycogen Storage Diseases and Myoclonus
- Neurological and metabolic disorders
- Botulinum Toxin and Related Neurological Disorders
- Cardiac Arrest and Resuscitation
- Neuroscience of respiration and sleep
- Neuroscience and Neural Engineering
- Voice and Speech Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Transcranial Magnetic Stimulation Studies
- Restless Legs Syndrome Research
- Epilepsy research and treatment
- Traumatic Brain Injury Research
- Neonatal and fetal brain pathology
University Medical Center Groningen
2015-2024
University of Groningen
2015-2024
Amsterdam Neuroscience
2020-2024
Amsterdam University Medical Centers
2024
University of Amsterdam
2024
Neuroscience Institute
2020
Mental Health Research UK
2018
Cardiff University
2018
BackgroundBeta-based adaptive Deep Brain Stimulation (aDBS) is effective in Parkinson's disease (PD), when assessed the immediate post-implantation phase. However, potential benefits of aDBS patients with electrodes chronically implanted, whom changes due to microlesion effect have disappeared, are yet be assessed.MethodsTo determine acute effectiveness and side-effect profile PD compared conventional continuous DBS (cDBS) no stimulation (NoStim), years after implantation, 13 undergoing...
Adaptive deep brain stimulation (aDBS) has been applied in Parkinson's disease (PD), based on the presence of brief high-amplitude beta (13-35 Hz) oscillation bursts subthalamic nucleus (STN), which correlate with symptom severity. Analogously, average low-frequency (LF) oscillatory power (4-12 internal globus pallidus (GPi) correlates dystonic symptoms and might be a suitable physiomarker for aDBS dystonia. Characterization pallidal could facilitate implementation GPi PD dystonia...
<h3>Objective</h3> To determine the contribution of electrophysiologic testing in diagnosis and anatomical classification myoclonus. <h3>Methods</h3> Participants with a clinical myoclonus were prospectively recruited, each undergoing videotaped examination battery tests. The its subtype was reviewed after 6 months context findings specialist review examination. <h3>Results</h3> Seventy-two patients recruited. Initial included 25 cortical myoclonus, 7 subcortical 2 spinal 15 functional...
The physical examination findings of early posthypoxic myoclonus (PHM) are associated with poor prognosis. Recent indicate that patients multifocal PHM, assumed to have a cortical origin, comparable outcome resuscitated without PHM. Generalized subcortical is still bad clinical outcome. It not known whether the electroencephalographic (EEG) differ between and generalized groups nor significance clearly defined. Forty-three PHM were retrospectively derived from an EEG database. Patients...
Low-frequency oscillations (LFO) detected in the internal globus pallidus of dystonia patients have been identified as a physiomarker for adaptive Deep Brain Stimulation (aDBS), since LFO correlate with dystonic symptoms and are rapidly suppressed by continuous DBS (cDBS). However, it is yet unclear how should be incorporated feedback aDBS.to test acute effects aDBS, using amplitude short-lived LFO-bursts to titrate stimulation, explore immediate cDBS on LFO-modulation symptoms, investigate...
Acute post-anoxic myoclonus (PAM) can be divided into an unfavorable (generalized/subcortical) and more favorable ((multi)focal/cortical) outcome group that could support prognostication in encephalopathy; however, the inter-rater variability of clinically assessing these PAM subtypes is unknown.We prospectively examined patients using a standardized video protocol. Videos were rated by three neurologists who classified phenotype (generalized/(multi)focal), stimulus sensitivity, localization...
<strong>Background:</strong> To systematically evaluate the effectiveness of deep brain stimulation globus pallidus internus (GPi-DBS) in dystonia on pre-operatively set functional priorities daily living.<br /><strong>Methods:</strong> Fifteen pediatric and adult patients (8 male; median age 32y, range 8–65) receiving GPi-DBS were recruited. All underwent a multidisciplinary evaluation before 1-year post DBS implantation. The Canadian Occupational Performance Measure (COPM) first identified...
Abstract Objective Posthypoxic myoclonus ( PHM ) in the first few days after resuscitation can be divided clinically into generalized and focal (uni‐ multifocal) subtypes. The former is associated with a subcortical origin poor prognosis patients postanoxic encephalopathy PAE ), latter cortical better prognosis. However, use of as prognosticator hampered by modest objectivity its clinical assessment. Therefore, we aimed to obtain anatomical neurophysiological investigations, relate these...
<strong>Background:</strong> Acute post-anoxic myoclonus (PAM) can be divided into an unfavorable (generalized/subcortical) and more favorable ((multi)focal/cortical) outcome group that could support prognostication in encephalopathy; however, the inter-rater variability of clinically assessing these PAM subtypes is unknown. <strong>Methods:</strong> We prospectively examined patients using a standardized video protocol. Videos were rated by three neurologists who classified phenotype...
Abstract Background Beta-based adaptive Deep Brain Stimulation (aDBS) is effective in Parkinson’s disease (PD), when assessed the immediate post-implantation phase. However, potential benefits of aDBS patients with electrodes chronically implanted, whom microlesion effect have disappeared, are yet to be assessed. Methods To determine acute effectiveness and side-effect profile PD compared conventional continuous DBS (cDBS) no stimulation (NoStim), years after implantation. 13 undergoing...
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established treatment in advanced Parkinson's disease (PD). However, clinical outcome after STN-DBS variable. The aim this study was to explore coherence antagonistic muscles measured with electromyography (EMG) as novel biomarker efficacy PD.EMG bilateral wrist and upper arm 21 PD patients recorded during three standardized motor tasks. Patients were one day prior DBS surgery (pre-DBS) 6 months afterwards (post-DBS)....