A5074184993- Phytochemistry and Bioactivity Studies
- Phytochemistry and Biological Activities
- Fungal Biology and Applications
- Medicinal Plants and Bioactive Compounds
- Alzheimer's disease research and treatments
- Computational Drug Discovery Methods
- Bioactive natural compounds
- Bioactive Compounds in Plants
- Drug-Induced Hepatotoxicity and Protection
- Pharmacology and Nanomedicine Research
- Urticaria and Related Conditions
- Malaria Research and Control
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Wound Healing and Treatments
- Peroxisome Proliferator-Activated Receptors
- Polysaccharides and Plant Cell Walls
- Pancreatic function and diabetes
- Advances in Cucurbitaceae Research
- Nanoplatforms for cancer theranostics
- Ocular Oncology and Treatments
- Phytochemistry Medicinal Plant Applications
- Natural Antidiabetic Agents Studies
- Nanoparticle-Based Drug Delivery
- Endoplasmic Reticulum Stress and Disease
University of Shizuoka
2022-2024
University of Nigeria
2014-2023
Alzheimer's Disease (AD) is the most common cause of dementia. Genetics, excessive exposure to environmental pollutants, as well unhealthy lifestyle practices are often linked development AD. No therapeutic approach has achieved complete success in treating AD; however, early detection and management with appropriate drugs key improving prognosis.The pathogenesis AD was extensively discussed order understand reasons for interventions suggested. The reviewed include use different agents...
The improvement of type 2 diabetes mellitus induced by naturally occurring polyphenols, known as flavonoids, has received considerable attention. However, there is a dearth information regarding the effect trihydroxyflavone apigenin on pancreatic β-cell function. In present study, anti-diabetic insulin secretion, apoptosis, and mechanism underlying its effects, were investigated in INS-ID line. results showed that concentration-dependently facilitated 11.1-mM glucose-induced which peaked at...
The search for pharmacologically effective agents among molecules bearing multiple functionalities is commonly practiced. In continuation of the new anti-malarial agents, pyrazole-hydrazine coupled Schiff-base derivatives previously synthesized were screened property.Here, in vivo prophylactic and curative activities compounds assessed while their binding affinity falcipain-2, a crucial enzyme Plasmodium survival, was done using computational techniques.The two (BepINH BepBeH) respectively...
Introduction Nobiletin is a polymethoxyflavonoid abundant in citrus peels and has been reported to have various bioactive effects. We previously that nobiletin inhibits endoplasmic reticulum stress-induced apoptosis the pancreatic β-cell line INS-1 continuous subcutaneous administration of suppresses progression diabetes by protecting β-cells type 2 diabetic db/db mice. In present study, we investigated effects oral ingestion Shiikuwasha extract rich on pathogenesis Materials methods A was...
Context: Some edible mushrooms are reputed to possess useful medicinal properties which related their ability modulate the protective responses of immune system.Objective: This study explored immunomodulatory and immunorestorative a hot aqueous extract (APTR) β-d-glucan-enriched polysaccharide fraction (BGP) local oyster mushroom Pleurutus tuberregium (Fr.) Singer (Pleurotaceae).Materials methods: Immunomodulatory activities were investigated by assessing specific none-specific in...
Chronic kidney disease, end-stage renal failure, and liver diseases are increasing worldwide constitute a huge burden on health care costs, with attendant high morbidity debility. Despite advances in modern medicine, there still no licensed drugs that satisfactorily restore lost or hepatic functions. In this study the chemoprotective effects of hot aqueous extract local edible oyster mushroom, Pleurotus tuberregium (APTR), was evaluated experimental toxicities. The effect APTR carbon...
Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related improvement type 2 diabetes. Our previous vitro study demonstrated insulinotropic and anti-apoptotic effects nobiletin pancreatic β-cells. These are postulated be responsible for its anti-diabetic activity. We evaluated on β-cells diabetic db/db mice. Nobiletin was filled into an osmotic pump implanted subcutaneously back mice weeks with continuous...
Purpose: To investigate the neuropharmacological effects of methanol leaf extract (ME) and fractions Phyllanthus muellerianus (PM) (Phyllanthaceae) (Kuntze) Exell in mice.
 Methods: Acute toxicity was carried out on using standard protocol. ME fractionated into hexane (HF), ethyl acetate (EF), (MF) fractions. Pentylenetetrazol (PTZ)-induced seizure, open field (OF) motor coordination (rotarod) tests were models employed. Mice allotted fourteen groups six animals each treated orally with...
The fruiting body of Auricularia auricula-judae has received attention in folk medicine due to its possible medicinal values. Therefore, this study evaluated the immunomodulatory effects hot aqueous extract (AAAJ) and β-D-glucan-rich polysaccharide fraction A. (BGPA) on specific nonspecific humoral cell mediated immune responses immunocompetent immunosuppressed mice. Oral supplementation with AAAJ or BGPA (100, 200, 400 mg/kg) produced significantly high titers total OVA TT IgG1 IgG2a...
Traditionally, morphological parts of Ceiba pentandra have been reported as remedies against numerous diseases. On this basis, the wound healing and anti-inflammatory effects extract fractions pentendra was investigated. Preliminary qualitative phytochemical screening test performed using HPLC fingerprint analysis. The (CPE) graded solvent polarity: n-hexane (HXCP), ethylacetate (EACP) Butanol (BNCP) were investigated for wound-healing potentials, excision incision models. Acute chronic...
Introduction Phyllanthus muellerianus (Kuntze) Exell. (Phyllanthaceae) is an evergreen monoecious shrub widely distributed in tropical and subtropical regions of the world. In South-eastern Nigeria, preparations from leaf used treating pain, epilepsy, convulsion, other central nervous system disorders. This study was aimed to evaluate anticonvulsant anxiolytic properties extract (PM) mice. Materials methods The methanol (ME) PM fractionated successively with solvents increasing polarities...