A5051720035- Click Chemistry and Applications
- Oral microbiology and periodontitis research
- HIV/AIDS drug development and treatment
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Malaria Research and Control
- Nanoplatforms for cancer theranostics
- Infective Endocarditis Diagnosis and Management
- Synthesis and Catalytic Reactions
- Advanced biosensing and bioanalysis techniques
- Advanced Proteomics Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Molecular Research
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects and Toxicity Studies
- Pediatric Pain Management Techniques
- Ubiquitin and proteasome pathways
- Nigella sativa pharmacological applications
- Advanced Biosensing Techniques and Applications
- Mesoporous Materials and Catalysis
- Menstrual Health and Disorders
- Acne and Rosacea Treatments and Effects
- Synthetic Organic Chemistry Methods
- Endometriosis Research and Treatment
Stanford University
2020-2025
Lundbeck (Denmark)
2022
University of California, Berkeley
2016-2018
Lawrence Berkeley National Laboratory
2016-2018
Kavli Energy NanoScience Institute
2016-2018
Surgery is the preferred treatment option for most solid tumors. However, inaccurate detection of cancer borders leads to either incomplete removal malignant cells or excess excision healthy tissue. While fluorescent contrast agents and imaging systems improve tumor visualization, they can suffer from low signal-to-background are prone technical artifacts. Ratiometric has potential eliminate many these issues such as uneven probe distribution, tissue autofluorescence, changes in positioning...
Abstract Background Abdominal pain poses a significant challenge for individuals with inflammatory bowel disease (IBD). Despite current treatments that target inflammation, IBD-associated abdominal often persists even in the absence of negatively impacting patients’ quality life. This persistence suggests factors other than inflammation may be at play. Our previous research bacterial proteases can directly influence excitability dorsal root ganglia neurons, many which are pain-sensing....
Peptide macrocycles are promising therapeutics for a variety of disease indications due to their overall metabolic stability and potential make highly selective binding interactions with targets. Recent advances in covalent macrocycle peptide discovery, driven by phage mRNA display methods, have enabled the rapid identification potent molecules from large libraires diverse macrocycles. However, there currently limited examples that can be used disrupt protein-protein even fewer function...
Abstract OBJECTIVE Abdominal pain poses a significant challenge for individuals with inflammatory bowel disease (IBD). Despite current treatments that target inflammation, IBD-associated abdominal often persists even in the absence of negatively impacting patients’ quality life. This persistence suggests factors other than inflammation may be contributing to pathology IBD. Our previous research bacterial proteases can directly influence excitability dorsal root ganglia neurons, many which...
Abstract Traditional methods for identifying selective protease substrates have primarily relied on synthetic libraries of linear peptides, which offer limited sequence and structural diversity. Here, we present an approach that leverages phage display technology to screen large chemically modified cyclic enabling the identification highly a interest. Our method uses reactive chemical linker cyclize peptides surface, while simultaneously incorporating affinity tag fluorescent reporter. The...
Abstract Macrocyclic peptides are attractive for chemoproteomic applications due to their modular synthesis and potential high target selectivity. We describe a solid phase method the efficient generation of libraries small macrocycles that contain an electrophile alkyne handle. The produces can be directly screened using simple SDS‐PAGE readouts then optimal lead molecules applied proteomic analysis. generated library 480 macrocyclic containing weakly reactive fluorosulfate (OSF)...
The Plasmodium proteasome is a promising antimalarial drug target due to its essential role in all parasite lifecycle stages. Furthermore, inhibitors have synergistic effects when combined with current first-line artemisinin and related analogues. Linear peptides that covalently inhibit the are effective at killing parasites low propensity for inducing resistance. However, these scaffolds generally suffer from poor pharmacokinetics bioavailability. Here we describe development of covalent,...
ABSTRACT Peptide macrocycles are promising therapeutics for a variety of disease indications due to their overall metabolic stability and potential make highly selective binding interactions with targets. Recent advances in covalent macrocycle peptide discovery, driven by phage mRNA display methods, have enabled the rapid identification potent molecules from large libraires diverse macrocycles. However, there currently limited examples that can be used disrupt protein-protein even fewer...
Malaria, caused by
Malaria, caused by Plasmodium falciparum, remains a significant health burden. A barrier for developing anti-malarial drugs is the ability of parasite to rapidly generate resistance. We demonstrated that Salinipostin (SalA), natural product, kills parasites inhibiting multiple lipid metabolizing serine hydrolases, mechanism with low propensity Given difficulty employing products as therapeutic agents, we synthesized library lipidic mixed alkyl/aryl phosphonates bioisosteres SalA. Two...
ABSTRACT Fluorescence-based contrast agents enable real-time detection of solid tumors and their neovasculature, making them ideal for use in image-guided surgery. Several have entered late-stage clinical trials or secured FDA approval, suggesting they are likely to become standard care cancer surgeries. One the key parameters optimize agent is molecular size, which dictates much pharmacokinetic pharmacodynamic properties agent. Here, we describe development a class protease-activated...
Fluorescence-based contrast agents enable real-time detection of solid tumors and their neovasculature, making them ideal for use in image-guided surgery. Several have entered late-stage clinical trials or secured FDA approval, suggesting they are likely to become the standard care cancer surgeries. One key parameters optimize is molecular size, which dictates much pharmacokinetic pharmacodynamic properties agent. Here, we describe development a class protease-activated quenched fluorescent...
<title>Abstract</title> <italic>Staphylococcus aureus</italic> is a leading cause of bacteria-associated mortality worldwide. This largely because infection sites are often difficult to localize and the bacteria forms biofilms which not effectively cleared using classical antibiotics. Therefore, there need for new tools both image treat <italic>S. infections. We previously identified group serine hydrolases known as fluorophosphonate-binding (Fphs), regulate aspects virulence lipid...
Macrocyclic peptides are attractive for chemoproteomic applications due to their modular synthesis and potential high target selectivity. We describe a solid phase method the efficient generation of libraries small macrocycles that contain an electrophile alkyne handle. The produces can be directly screened using simple SDS-PAGE readouts then optimal lead molecules applied proteomic analysis. generated library 480 macrocyclic containing weakly reactive fluorosulfate (OSF) electrophile....
ABSTRACT The Plasmodium proteasome is a promising antimalarial drug target due to its essential role in all parasite lifecycle stages. Furthermore, inhibitors have synergistic effects when combined with current first-line artemisinins. Linear peptides that covalently inhibit the are effective at killing parasites and low propensity for inducing resistance. However, these scaffolds generally suffer from poor pharmacokinetics bioavailability. Here we describe development of covalent,...