A5020964577- Cancer-related Molecular Pathways
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Mesenchymal stem cell research
- PI3K/AKT/mTOR signaling in cancer
- Estrogen and related hormone effects
- HIV/AIDS drug development and treatment
- RNA Research and Splicing
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
- HIV Research and Treatment
- CRISPR and Genetic Engineering
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- RNA Interference and Gene Delivery
- Aldose Reductase and Taurine
- Cell death mechanisms and regulation
National Hellenic Research Foundation
2015-2024
National and Kapodistrian University of Athens
1998-2000
Abstract The accurate execution of DNA replication requires a strict control the licensing factors hCdt1 and hCdc6. role these key molecules in carcinogenesis has not been clarified. To examine how early during cancer development deregulation occurs, we investigated their status epithelial lesions covering progressive stages hyperplasia, dysplasia, full malignancy, mostly from same patients. Abnormal accumulation both proteins occurred stage dysplasia. A frequent cause unregulated hCdc6...
Mesenchymal stem cells (MSCs) are somatic with a dual capacity for self-renewal and differentiation, diverse therapeutic applicability, both experimentally in the clinic. These can be isolated from various human tissues that may differ anatomically or developmentally relative ease. Heterogeneity due to biological origin vitro manipulation is, nevertheless, considerable equate differences qualitative quantitative characteristics which prove crucial successful use. With this mind, present...
Human kallikrein-related peptidase 6 (KLK6) was cloned as a putative class II tumor suppressor based on its inactivated expression in metastatic breast cancer. Here, we investigated the mechanism(s) underlying silencing of KLK6 gene cancer and implications for progression. We present evidence that tumor-specific loss is due to hypermethylation specific CpGs located proximal promoter. Methylation-dependent binding methyl CpG-binding protein 2 formation repressive chromatin mediated by...
Natural products are characterized by extreme structural diversity and thus they offer a unique source for the identification of novel anti-tumor agents. Herein, we report that herbal substance acteoside being isolated advanced phytochemical methods from Lippia citriodora leaves showed enhanced cytotoxicity against metastatic tumor cells; acted in synergy with various cytotoxic agents it sensitized chemoresistant cancer cells. Acteoside was not toxic physiological cellular contexts, while...