A5073823676- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Advanced Drug Delivery Systems
- Pharmacology and Obesity Treatment
- Pharmaceutical studies and practices
- Analytical Chemistry and Chromatography
- Muscle metabolism and nutrition
- Crystallization and Solubility Studies
- Polymer Synthesis and Characterization
- Proteins in Food Systems
- Food composition and properties
- Drug-Induced Hepatotoxicity and Protection
- Inflammatory mediators and NSAID effects
- Coal and Coke Industries Research
- Diet and metabolism studies
- Food Industry and Aquatic Biology
Medical University of Lublin
2012-2019
Caffeine increases the analgesic properties of acetaminophen and therefore it is reasonable to use both substances together in one drug form stronger pain. Currently, there are no commercially available pharmaceutical combination products containing caffeine, which present as granules. The aim study was obtain twelve different granules with these therapeutic determine effect various excipients on quality form. All were made by wet granulation. Two types binders used: polyethylene glycol 6000...
The purpose of this work was to determine the effect starch hydrolysates (SH) on physicochemical properties suppositories. study conducted with suppositories acetaminophen (AAP) a typical antipyretic analgesic, as model drug lipophilic (cocoa butter) and hydrophilic base (polyethylene glycol 1500 + 400). without addition SH were examined for tests according European Pharmacopoeia 8th edition (Ph. Eur.): uniformity mass single-dose preparation test, softening time determination disintegration...
Four formulas of granules with caffeine were chosen to examine the influence excipients on dissolution profiles active substance from this drug form. The formula I: 1.0 parts, potato starch 69,3 lactose 29,7 glycerol 86% 2.0 gelatin mucilage 4% (w/w) 98.0 parts; II: Avicel 49,5 III: D-Mannitol 99,0 parts and IV: 0.5% solution PVP 100.0 parts. This was prepared by 0.5 in 95.5 mixture ethanol 96° water 1:1 (w/w). obtained wet granulator. Their flow properties, moisture content, disintegration...
A simple, rapid, accurate and precise spectrophotometric method for simultaneous estimation of diclofenac sodium papaverine hydrochloride in combined tablet the dissolution media used release studies has been developed. It employs formation solving equation using two analytical wavelengths corresponding to medium. This obeys Beer’s Law employed concentration ranges 2.5-25 µg/mL active substances. The was validated.
The objective of this study was to develop tablet formulations sulphadimidine sodium (SDD-Na) and trimethoprim (TMP), evaluate compare the efficiency some excipients such as: superdisintegrant - croscarmellose (Ac-Di-Sol), silicon dioxide (Aerosil), lactose microcrystalline cellulose (Avicel pH-101) as base for physical tablets properties increasing dissolution rate SDD-Na TMP. All were prepared by wet granulation process. Dissolution DP 30,45,60 (percent drug dissolved at 30, 45 60...
Abstract Acetaminophen and caffeine, popular therapeutic substances used to relieve pain or alleviate the symptoms of cold. The aims study were comparison granules, in terms dissolution rate moreover development spectrophotometric method simultaneous determination both active pharmaceutical ingredients (APIs) granules. granules tested by two pharmacopoeial methods for solid dosage forms, profiles each formulation compared. A medicinal double calibration using derivative spectrophotometry was...
In this study seven tablet batches were prepared by wet granulation process using different excipients such as: superdisintegrant – croscarmellose sodium (Ac- Di- Sol), silicon dioxide (Aerosil), lactose, pregelatinized starch (CPharm Gel) and microcrystalline cellulose (Avicel pH- 101). Sulfadimidine (SDD-Na) trimethoprim (TMP) used as model active substances. Tablets evaluated for uniformity of weight, hardness, friability, drug content, disintegration time dissolution properties. To the...
Using modified starch in suspensions is commonly practiced food, pharmaceutical and other industries [3, 6]. The purpose of this study was to investigate the influence hydrolysates, received according our prescription, on properties suspensions. Prepared Z01 – Z05 with PR, as model drug, were examined for physical tests. addition 20 % SH2 or SH4, suspending agent, increased stability preparations (0.04 cm/day 0.05 cm/day, respectively). Drug release test extraction method conducted during 24...