A5068032321- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Pharmacological Effects and Toxicity Studies
- Adenosine and Purinergic Signaling
- Treatment of Major Depression
- Pharmacological Receptor Mechanisms and Effects
- Epilepsy research and treatment
- Mast cells and histamine
- Neurotransmitter Receptor Influence on Behavior
- Pharmaceutical studies and practices
- Coffee research and impacts
- Neuroendocrine regulation and behavior
- Bipolar Disorder and Treatment
- Pharmacology and Obesity Treatment
- Ion channel regulation and function
- Cannabis and Cannabinoid Research
- Advanced Drug Delivery Systems
- Receptor Mechanisms and Signaling
- Natural product bioactivities and synthesis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Zebrafish Biomedical Research Applications
- Analytical Chemistry and Chromatography
- Agriculture, Plant Science, Crop Management
Medical University of Lublin
2014-2023
Warsaw University of Life Sciences
2019
Niepubliczna Wyższa Szkoła Medyczna
1990
Unsatisfactory therapeutic effects of currently used antidepressants force to search for new pharmacological treatment strategies. Recent research points the relationship between depressive disorders and adenosinergic system. Therefore, main goal our studies was evaluate DMPX (3 mg/kg, i.p.), which possesses selectivity adenosine A2A receptors versus A1 receptors, on activity imipramine (15 escitalopram (2.5 reboxetine (2 i.p.) given in subtherapeutic doses. The carried out using forced swim...
Abstract The antibacterial and antifungal activity of the essential oil Artemisia asiatica Nakai, its main constituents: 1,8‐cineole selin‐11‐en‐4α‐ol monoterpene alcohols fraction were determined against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Rhodotorula rubra Aspergillus fumigatus . exhibited a good inhibitory bacteria fungi. showed highest activity. Copyright © 2002 John Wiley & Sons. Ltd.
One of the newest substances, whose antidepressant activity was shown is traxoprodil, which a selective antagonist NR2B subunit NMDA receptor. The main goal present study to evaluate effect traxoprodil on animals' behavior using forced swim test (FST), as well (10 mg/kg) antidepressants, such imipramine (15 mg/kg), fluoxetine (5 escitalopram (2 and reboxetine (2.5 mg/kg). Serotonergic lesion experiment agonists serotonin receptors 5-HT1A 5-HT2 conducted role serotonergic system in action...
The main goal of the present study was to evaluate influence adenosine A1 receptor (A1R) antagonist — DPCPX on depressive-like behavior in mice, as well effect activity imipramine, escitalopram, and reboxetine, each at non-effective doses. its selected antidepressants evaluated forced swim test (FST) tail suspension (TST) mice. Locomotor measured verify exclude false-positive data obtained FST TST. Moreover, serum brain concentrations tested were determined using HPLC. DPCPX, doses 2 4...
Caffeine increases the analgesic properties of acetaminophen and therefore it is reasonable to use both substances together in one drug form stronger pain. Currently, there are no commercially available pharmaceutical combination products containing caffeine, which present as granules. The aim study was obtain twelve different granules with these therapeutic determine effect various excipients on quality form. All were made by wet granulation. Two types binders used: polyethylene glycol 6000...
The purpose of this work was to determine the effect starch hydrolysates (SH) on physicochemical properties suppositories. study conducted with suppositories acetaminophen (AAP) a typical antipyretic analgesic, as model drug lipophilic (cocoa butter) and hydrophilic base (polyethylene glycol 1500 + 400). without addition SH were examined for tests according European Pharmacopoeia 8th edition (Ph. Eur.): uniformity mass single-dose preparation test, softening time determination disintegration...
Available data support the notion that cannabinoids, whose therapeutic value is limited due to severe adverse reactions, could be beneficial as adjunctive agents in management of mood disorders. Polytherapy, which superior monotherapy terms effectiveness, usually requires lower doses individual components. Therefore, main objective our study was determine whether administration cannabinoid (CB) receptor ligands would enhance antidepressant activity atypical drugs, i.e. agomelatine and...
Abstract The objective of this study was to evaluate the anticonvulsant properties picolinic acid 2‐fluoro‐benzylamide (Pic‐2F‐BZA) in numerous experimental seizure models [maximal electroshock (MES), bicuculline (BIC), pentylenetetrazole (PTZ), pilocarpine (PILO), α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic (AMPA), kainic (KA) and N ‐methyl‐ d ‐aspartic (NMDA)‐induced seizures]. Moreover, acute adverse‐effect profile agent with respect impairment motor performance assessed animals...
The main goal of our study was to investigate whether a selective antagonism the adenosine A1 or A2A receptors is able enhance antidepressant activity commonly prescribed drugs.All experiments were carried out on male Albino Swiss mice. forced swim test and tail suspension used evaluate antidepressant-like potential. Drug concentrations in animals' serum brains measured by high-performance liquid chromatography.The potential moclobemide (1.5 mg/kg), venlafaxine (1 mg/kg) bupropion (10...
Abstract Background Though there are several classes of antidepressant drugs available on the pharmaceutical market, depression that affects globally over 320 million people is still undertreated. Scientists have made attempts to develop novel therapeutical strategies maximize effectiveness therapy and minimize undesired reactions. One ideas use either dual-action agents or combined administration two substances affect diverse neurotransmissions. Thus, we investigated whether selected CB...
Abstract Background The purpose of the study was to evaluate in vitro antibacterial effect experimental eye drops with bacteriophages elimination Staphylococcus spp . isolated from dogs bacterial conjunctivitis.. material collected independent clinical signs conjunctivitis. spp. were identified by phenotypic and genotypic methods (MALDI-TOF MS mass spectrometry). Antibiotic resistance determined disc-diffusion method. Phage activity (Plaque forming units, PFU) on double-layer agar plates....
The purpose of the study was to investigate whether co-administration Mg2+ and Zn2+ with selective A1 A2A receptor antagonists might be an interesting antidepressant strategy. Forced swim, tail suspension, spontaneous locomotor motility tests in mice were performed. Further, biochemical molecular studies conducted. obtained results indicate interaction DPCPX istradefylline manifested antidepressant-like effect. reduction BDNF serum level after noted. Additionally, or Zn2+, both alone...
The main goal of this study was to determine the antidepressant-like potential co-administration sodium selenite (Se) and selective adenosine A1 A2A antagonists DPCPX istradefylline (IST), respectively, in mice despair tests. Biochemical studies were performed elucidate action mechanisms investigated treatment strategies. results confirmed that, when administered by itself, Se exerts an effect FST TST that activity is dose-dependent. Further experiments demonstrated (0.25 mg/kg)...
Abstract Bilayer and multi-layer tablets are enjoying growing popularity among original drug generic product manufacturers. Multi-layer have many key benefits compared to classic immediate-release tablets. The use of such solid oral dosage forms simplifies dosing regimens in combination therapy, thus improves patient compliance. However, the technology multilayer is demanding requires precise choice excipients production parameters with regard each technological step. main tablets, certain...
Depressed patients often present increased consumption of caffeine. We aimed to investigate the effects chronic treatment with caffeine (5 mg/kg, twice daily for 14 days) on activity single, ineffective doses agomelatine (20 mg/kg) or mianserin (10 given day 15 alone simultaneously used forced swim test (FST), tail suspension (TST), and locomotor in mice quantitative real-time PCR analysis selected genes cerebral cortex (Cx). There were no changes immobility time between that received saline...
The goal of our study was to examine the long-term effect vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice.VGB administered for 3 7 days. Convulsions were evoked by PTZ at its CD97 (99 mg/kg). influence CLO, ETX VPA alone or combination with VGB motor performance memory analyzed. (GABA) concentration mice brain plasma as...
Abstract In this study, the stability of 10% hydrogen peroxide aqueous and non-aqueous solutions with addition 6% (w/w) urea was evaluated. The were stored at 20°C, 30°C 40°C, decomposition proceeded according to first-order kinetics. With in solutions, rate constant increased activation energy decreased. temperature storage also affected substance, however, prepared PEG-300, stabilized had best constancy.