A5070490450- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Bipolar Disorder and Treatment
- Zebrafish Biomedical Research Applications
- Treatment of Major Depression
- Coffee research and impacts
- Urinary Bladder and Prostate Research
- Adenosine and Purinergic Signaling
- Magnesium in Health and Disease
- Pharmacological Receptor Mechanisms and Effects
- Hormonal and reproductive studies
- Neuroscience of respiration and sleep
- Amino Acid Enzymes and Metabolism
- Diet and metabolism studies
- Forensic Toxicology and Drug Analysis
- Eating Disorders and Behaviors
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Receptor Mechanisms and Signaling
- Medication Adherence and Compliance
- Nerve injury and regeneration
- Fatty Acid Research and Health
- Ion channel regulation and function
Medical University of Lublin
2016-2025
University of Łódź
2012
Lodz University of Technology
2012
Institute of Bioorganic Chemistry, Polish Academy of Sciences
2011
The COVID-19 pandemic accelerated the online purchase of goods and services in which today’s e-pharmacy is now an integral part healthcare provisions developed countries. aim our research was to assess frequency attitudes European consumers purchasing medications prior following Visegrad Group countries (V4). An cross-sectional study conducted between May-August 2022. A 25-item questionnaire with single choice 5-point Likert scale answers used implemented Google forms Pollfish. sampling 2087...
Abstract Obesity is a complex chronic condition associated with multiple health risks, including visceral obesity, which particularly detrimental. To gain insight into the mechanisms underlying obesity and its pathologies, novel zebrafish model was established using an innovative high-fat diet (HFD). The primary goal to induce in study structural changes. achieve this, unique HFD consisting of 40% beef fat (HFD40) developed supplemented magnesium aluminometasilicate improve stability high...
Given the comprehensive examination of role fatty acid-rich diets in central nervous system development children, this study bridges significant gaps understanding dietary effects on neurodevelopment. It delves into essential functions acids neurodevelopment, including their contributions to neuronal membrane formation, neuroinflammatory modulation, neurogenesis, and synaptic plasticity. Despite acknowledged importance these nutrients, review reveals a lack synthesis current research,...
Caffeine is the most widely used behaviorally active drug in world which exerts its activity on central nervous system through adenosine receptors. Worrying data indicate that excessive caffeine intake applies to patients suffering from mental disorders, including depression. The main goal of present study was evaluate influence animals' behavior forced swim test (FST) as well effect (5 mg/kg) six typical antidepressants, such imipramine (15 mg/kg), desipramine (10 fluoxetine paroxetine (0.5...
Unsatisfactory therapeutic effects of currently used antidepressants force to search for new pharmacological treatment strategies. Recent research points the relationship between depressive disorders and adenosinergic system. Therefore, main goal our studies was evaluate DMPX (3 mg/kg, i.p.), which possesses selectivity adenosine A2A receptors versus A1 receptors, on activity imipramine (15 escitalopram (2.5 reboxetine (2 i.p.) given in subtherapeutic doses. The carried out using forced swim...
The objective of this study was to assess the antidepressant efficacy a novel imipramine–magnesium (IMI–Mg) complex in comparison administration imipramine and magnesium individually. utilized adult male albino Swiss mice. Behavioral assessments were conducted using forced swim test (FST) tail suspension (TST). A locomotor activity exclude false positive results FST TST. Moreover, assessed oxidative stress levels mice subjected acute environmental by measuring glutathione peroxidase,...
One of the newest substances, whose antidepressant activity was shown is traxoprodil, which a selective antagonist NR2B subunit NMDA receptor. The main goal present study to evaluate effect traxoprodil on animals' behavior using forced swim test (FST), as well (10 mg/kg) antidepressants, such imipramine (15 mg/kg), fluoxetine (5 escitalopram (2 and reboxetine (2.5 mg/kg). Serotonergic lesion experiment agonists serotonin receptors 5-HT1A 5-HT2 conducted role serotonergic system in action...
The main goal of the present study was to evaluate influence adenosine A1 receptor (A1R) antagonist — DPCPX on depressive-like behavior in mice, as well effect activity imipramine, escitalopram, and reboxetine, each at non-effective doses. its selected antidepressants evaluated forced swim test (FST) tail suspension (TST) mice. Locomotor measured verify exclude false-positive data obtained FST TST. Moreover, serum brain concentrations tested were determined using HPLC. DPCPX, doses 2 4...
The objective of the study was to ascertain antidepressant potential co-administration NMDA receptor ligands and selective adenosine A1 A2A antagonists.
In view of the fact that GPR55 receptors are localized in brain areas implicated pathophysiology depression, gene expression is reduced dorsolateral prefrontal cortex suicide victims, and receptor agonism exerts an anxiolytic-like effect, have drawn our attention as a potential target treatment mood disorders. Therefore, present study, we wanted to check whether 7-day intravenous administration O-1602 (0.25 mg/kg/day) - phytocannabinoid-like analogue cannabidiol belongs agonists receptors,...
Several studies with larvae and adult zebrafish have shown that old new antiseizure drugs (ASDs) produce discrepant results in seizure tests, locomotor activity or anxiety models. In this study, the pentylenetetrazole test (PTZ) was performed to assess effectiveness of four ASDs: lamotrigine (LTG), topiramate (TPM), felbamate (FBM), levetiracetam (LEV) subsequent stages seizures fish. All ASDs were administered intraperitoneally (i.p.). The time maximal anticonvulsant effect dose-response...