A5089758045- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Nutritional Studies and Diet
- Colorectal Cancer Screening and Detection
- Birth, Development, and Health
- Pancreatic and Hepatic Oncology Research
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Biochemical Acid Research Studies
- Eating Disorders and Behaviors
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Cancer Risks and Factors
- Chromatography in Natural Products
- Gastroesophageal reflux and treatments
- Toxin Mechanisms and Immunotoxins
- Estrogen and related hormone effects
- Phytochemistry and biological activity of medicinal plants
- Regulation of Appetite and Obesity
- Esophageal Cancer Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine regulation and behavior
- Genetic factors in colorectal cancer
- Dietary Effects on Health
- Zebrafish Biomedical Research Applications
Medical University of Lublin
2010-2024
Medical University of Warsaw
2020
Abstract Obesity is a complex chronic condition associated with multiple health risks, including visceral obesity, which particularly detrimental. To gain insight into the mechanisms underlying obesity and its pathologies, novel zebrafish model was established using an innovative high-fat diet (HFD). The primary goal to induce in study structural changes. achieve this, unique HFD consisting of 40% beef fat (HFD40) developed supplemented magnesium aluminometasilicate improve stability high...
Given the comprehensive examination of role fatty acid-rich diets in central nervous system development children, this study bridges significant gaps understanding dietary effects on neurodevelopment. It delves into essential functions acids neurodevelopment, including their contributions to neuronal membrane formation, neuroinflammatory modulation, neurogenesis, and synaptic plasticity. Despite acknowledged importance these nutrients, review reveals a lack synthesis current research,...
The colon and rectum are common sites of food-related cancer in developed countries. Recent studies strongly suggest that red meat intake is associated with cancer, whereas for rectal such an association still needs to be proved. aim the study was assess role total amount frequency colorectal carcinogenesis based on published data using meta-analysis methods.The literature until 2009 selected from: MEDLINE, PubMed, Scopus, Embase, CancerLit, Google Scholar Cochrane Library databases. used...
Acute liver failure (ALF) is a life-threatening disorder of function. Kynurenic acid (KYNA), tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food its potential role digestive system was recently reported. The aim this study to define effect KYNA on failure. Wistar rat model thioacetamide-induced injury used. Morphological biochemical analyses as well measurement content hepatoprotective herbal...
The global increase in resorting to artificial nutritional formulas replacing breastfeeding has been identified among the complex causes of obesity epidemic infants and children. One factors recently recognized influence metabolism weight gain is kynurenic acid (KYNA), an agonist G protein-coupled receptor (GPR35). Therefore aim study was determine concentration KYNA comparison with its level human breast milk evaluate developmental changes rats exposed enriched diet during time...
Kynurenic acid (KYNA) is a neuroactive metabolite of tryptophan. KYNA naturally occurs in breast milk and its content increases with lactation, indicating the role neonatal nutrition general growth long-term health effects. also an antagonist ionotropic glutamate receptors expressed bone cells. The aim this study was to establish effects chronic supplementation on homeostasis young rats, using mandible as model bone. Female male newborn Wistar rats were divided into control KYNA-administered...
The introduction of markers which help in the identification patients prone to suffer from postoperative complications enables recognize them more easily and thus, treat effectively. THE AIM OF STUDY was evaluate complete blood count indicators, as well preoperative results obtained on basis POSSUM P-POSSUM scoring systems, considering prediction after surgical resections pancreato-duodenal area.A prospective 30-day non-interventional clinical study conducted a group 65 who underwent...
High-fat diet (HFD)-induced obesity is a global health concern associated with gastrointestinal disorders. While mammalian models have elucidated the effects of HFD on intestinal structure and function, its impact zebrafish, crucial model for studying diet-induced dysfunction, remains inadequately characterized. This study investigated influence zebrafish morphology, tight junction (TJ) protein expression, inflammatory markers. Zebrafish fed control or 40% 60% fat exhibited significant...
The aim of the study was to assess incidence gastroesophageal reflux disease (GERD) in young females with anorexia nervosa (AN).Participation proposed AN aged 12-18 who were hospitalized Department Child Psychiatry, Medical University Warsaw. Exclusion criteria psychiatric disorders other than and treatment prokinetic drugs and/or antacids (such as proton pump inhibitors or histamine receptor antagonists) last 2 weeks prior study. Patients interviewed for gastrointestinal symptoms that can...
Emodin-8-O-glucoside (E-8-O-G) is a glycosylated derivative of emodin that exhibits numerous biological activities, including immunomodulatory, anti-inflammatory, antioxidant, hepatoprotective, or anticancer activities. However, there are no reports on the activity E-8-O-G against cancers nervous system. Therefore, aim study was to investigate antiproliferative and cytotoxic effect in SK-N-AS neuroblastoma, T98G human glioblastoma, C6 mouse glioblastoma cancer cells. As source methanolic...
Abstract The levels of tryptophan (TRP) and its main metabolite kynurenic acid (KYNA) were measured in rat livers treated with raloxifene – a selective estrogen receptor modulator. research was conducted by applying high-performance liquid chromatography on 5 μm Zorbax Eclipse XDB-C18 column. Selective fluorescence detection (FL) performed at an excitation 219 nm emission 360 for TRP KYNA. assays showed good linearity (R 2 >0.95) within the tested ranges 0.045-0.20 µg mL −1 , 0.025-0.32...