A5033862921- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Urinary Bladder and Prostate Research
- Stress Responses and Cortisol
- Zebrafish Biomedical Research Applications
- Adenosine and Purinergic Signaling
- Magnesium in Health and Disease
- Coffee research and impacts
- Pharmacological Receptor Mechanisms and Effects
- Diet, Metabolism, and Disease
- Antifungal resistance and susceptibility
- Hormonal and reproductive studies
- Amino Acid Enzymes and Metabolism
- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Forensic Toxicology and Drug Analysis
- Neuroendocrine regulation and behavior
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
Medical University of Lublin
2016-2025
The COVID-19 pandemic accelerated the online purchase of goods and services in which today’s e-pharmacy is now an integral part healthcare provisions developed countries. aim our research was to assess frequency attitudes European consumers purchasing medications prior following Visegrad Group countries (V4). An cross-sectional study conducted between May-August 2022. A 25-item questionnaire with single choice 5-point Likert scale answers used implemented Google forms Pollfish. sampling 2087...
Given the comprehensive examination of role fatty acid-rich diets in central nervous system development children, this study bridges significant gaps understanding dietary effects on neurodevelopment. It delves into essential functions acids neurodevelopment, including their contributions to neuronal membrane formation, neuroinflammatory modulation, neurogenesis, and synaptic plasticity. Despite acknowledged importance these nutrients, review reveals a lack synthesis current research,...
Caffeine is the most widely used behaviorally active drug in world which exerts its activity on central nervous system through adenosine receptors. Worrying data indicate that excessive caffeine intake applies to patients suffering from mental disorders, including depression. The main goal of present study was evaluate influence animals' behavior forced swim test (FST) as well effect (5 mg/kg) six typical antidepressants, such imipramine (15 mg/kg), desipramine (10 fluoxetine paroxetine (0.5...
Unsatisfactory therapeutic effects of currently used antidepressants force to search for new pharmacological treatment strategies. Recent research points the relationship between depressive disorders and adenosinergic system. Therefore, main goal our studies was evaluate DMPX (3 mg/kg, i.p.), which possesses selectivity adenosine A2A receptors versus A1 receptors, on activity imipramine (15 escitalopram (2.5 reboxetine (2 i.p.) given in subtherapeutic doses. The carried out using forced swim...
The objective of this study was to assess the antidepressant efficacy a novel imipramine–magnesium (IMI–Mg) complex in comparison administration imipramine and magnesium individually. utilized adult male albino Swiss mice. Behavioral assessments were conducted using forced swim test (FST) tail suspension (TST). A locomotor activity exclude false positive results FST TST. Moreover, assessed oxidative stress levels mice subjected acute environmental by measuring glutathione peroxidase,...
This study assessed the toxicity and therapeutic potential of Angelica dahurica pubescens using Danio rerio (zebrafish) larvae. Toxicity was evaluated through mortality, malformations, gene expression changes related to stress HPA axis. A. demonstrated low (LD50 (50% lethal dose) >200 µg/mL), with no significant malformations at 15–30 µg/mL, although higher doses caused edemas heart defects. exhibited toxicity, 100% mortality 200 µg/mL severe malformations. Both species showed...
Hemorrhagic cystitis often develops in patients treated with cyclophosphamide (CYP). Studies have indicated that Rho kinase (ROCK) inhibitors may suppress detrusor overactivity symptoms and possess anti-inflammatory properties. The aim of the present study was to investigate whether inhibition ROCK reduces cystometric histopathological changes associated CYP-induced cystitis. rats received GSK 269962, a inhibitor, at dose 30 mg/kg daily, or vehicle for 7 days. Then, acute chemical leading...
One of the newest substances, whose antidepressant activity was shown is traxoprodil, which a selective antagonist NR2B subunit NMDA receptor. The main goal present study to evaluate effect traxoprodil on animals' behavior using forced swim test (FST), as well (10 mg/kg) antidepressants, such imipramine (15 mg/kg), fluoxetine (5 escitalopram (2 and reboxetine (2.5 mg/kg). Serotonergic lesion experiment agonists serotonin receptors 5-HT1A 5-HT2 conducted role serotonergic system in action...
The main goal of the present study was to evaluate influence adenosine A1 receptor (A1R) antagonist — DPCPX on depressive-like behavior in mice, as well effect activity imipramine, escitalopram, and reboxetine, each at non-effective doses. its selected antidepressants evaluated forced swim test (FST) tail suspension (TST) mice. Locomotor measured verify exclude false-positive data obtained FST TST. Moreover, serum brain concentrations tested were determined using HPLC. DPCPX, doses 2 4...
The objective of the study was to ascertain antidepressant potential co-administration NMDA receptor ligands and selective adenosine A1 A2A antagonists.