A5075211946- Orthopedic Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Diphtheria, Corynebacterium, and Tetanus
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Stress Responses and Cortisol
- Immune Cell Function and Interaction
- Neuroendocrine regulation and behavior
- Hypothalamic control of reproductive hormones
- Cardiac Health and Mental Health
- Veterinary Equine Medical Research
- Muscle and Compartmental Disorders
- Cytokine Signaling Pathways and Interactions
- Hip and Femur Fractures
- Bone fractures and treatments
- Sports injuries and prevention
- Immune Response and Inflammation
- Bacterial Identification and Susceptibility Testing
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory mediators and NSAID effects
University of South Dakota
2025
Boston Medical Center
2024-2025
Duke University
2020-2022
Duke Medical Center
2020-2021
Background Patients treated at a health safety-net hospital have increased medical complexity and social determinants of that are associated with an increasing risk complications after TKA THA. Fast-track rapid recovery protocols (RRPs) reduced length stay in the general population; however, whether is case among patients who socioeconomically disadvantaged hospitals remains poorly defined. Questions/purposes When RRP protocol implemented THA: (1) Was there change complications, specifically...
Previous studies have shown that corticosterone rapidly alters extracellular serotonin (5-hydroxytryptamine; 5-HT) concentrations in the dorsomedial hypothalamus (DMH) of adult male rats, suggesting a role for actions DMH regulation physiological and behavioral responses. Whether or not also female dependence this effect on ovarian hormones, is known. To determine effects 17β-estradiol (E2), progesterone (P), DMH, and/or P were delivered into ovariectomized rats via reverse microdialysis...
Compartment syndrome is an orthopaedic emergency with moderate-to-severe sequela (pain, muscle contracture, nerve damage, infection, rhabdomyolysis, renal failure, etc.) if inadequately treated and can be difficult to diagnose in a timely fashion. Further complicating diagnosis are atypical presentations resulting compartment syndrome. This case concerns 31-year-old man who presented isolated left closed transverse fibular shaft fracture after being pedestrian struck by high-speed motor...
Prosthetic joint infections (PJIs) are typically caused by Staphylococcus aureus and coagulase-negative Staphylococci species. Corynebacterium species microorganisms of the human skin mucous membranes that often considered contaminants when grown in culture. In past, were classified as diphtheroids based on growing gram-positive rods aerobic environments, but with advances technology, identification has improved. can cause infection, there few case reports orthopaedic infection. We present 3...
The inflammatory response to joint injury, specifically intra-articular fracture, has been implicated in posttraumatic arthritis development. However, the role of T cells regulating development is unclear. We hypothesized that absence would lead less severe following fracture. cell-deficient, athymic nude, and wild-type C57BL/6NJ mice were assessed at 8 weeks closed articular Joints using histologic scores arthritis, synovitis, bone morphology via micro computed tomography. Cells profiled...
Posttraumatic inflammation after joint injury, ranging from sprains to articular fracture, contributes the development of arthritis, and administration interleukin 1 (IL-1) receptor antagonist (IL-1Ra) is a potential intervention mitigate this response. Although IL-1Ra mitigates cartilage degenerative changes induced by IL-1, lidocaine used for local pain management in acute injury. Intra-articular delivery both drugs combination would be novel possibly disease-modifying treatment. However,...