A5100366751- Liver Disease Diagnosis and Treatment
- Sulfur Compounds in Biology
- Carbohydrate Chemistry and Synthesis
- Diet, Metabolism, and Disease
- Molecular Sensors and Ion Detection
- Nutrition, Genetics, and Disease
- Air Quality and Health Impacts
- Click Chemistry and Applications
- Natural product bioactivities and synthesis
- Advancements in Transdermal Drug Delivery
- Nutritional Studies and Diet
- Pneumonia and Respiratory Infections
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
- Folate and B Vitamins Research
- Lanthanide and Transition Metal Complexes
- Educational Reforms and Innovations
- Fetal and Pediatric Neurological Disorders
- Parvovirus B19 Infection Studies
- Pharmacological Effects of Natural Compounds
- Advanced biosensing and bioanalysis techniques
- Cyclopropane Reaction Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Occupational Health and Safety Research
- Retinal Imaging and Analysis
Beijing Tongren Hospital
2025
Capital Medical University
2025
Jinan University
2023-2024
Shanxi University
2024
Xi’an Jiaotong-Liverpool University
2024
Fudan University
2022-2023
Shenzhen Institutes of Advanced Technology
2023
Chinese Academy of Sciences
2023
Shenyang Pharmaceutical University
1997-2019
China Medical University
2019
Maternal betaine supplementation has been proven to alleviate non-alcoholic fatty liver disease (NAFLD) in offspring caused by maternal high-fat diet (MHFD). The gut-liver axis plays an important role NAFLD pathogenesis. However, whether can the is unknown. C57BL/6J mice were fed with for 4 weeks before mating, and supplemented 1% during pregnancy lactation. After weaning, standard 10 weeks. reduced hepatic triglyceride content alleviated steatosis exposed MHFD. Furthermore, mRNA expression...
Hydrogen bonding interaction was considered to play a critical role in controlling drug release from transdermal patch. However, the quantitative evaluation of hydrogen strength between and polar functional group rarely reported, relationship controlled capacity pressure sensitive adhesive (PSA) not well understood. The present study shed light on this relationship.
Aims: To evaluate and compare lipid accumulation product (LAP) with alanine aminotransferase (ALT), aspartate (AST), visceral adiposity index (VAI) triglyceride-glucose (TyG) as biomarkers for hepatic steatosis nonalcoholic fatty liver disease (NAFLD). Methods: LAP, ALT, AST, VAI TyG were measured in 52 biopsy-proven NAFLD patients 21 control subjects. Additionally, LAP was also 448 ultrasound-proven 1009 Results: positively associated inflammation NAFLD. The risk of related to TyG, but...
Abstract Cataract is one of the most common blinding eye diseases and can be treated by surgery. However, because cataract patients may also suffer from other diseases, ophthalmologists must diagnose them before The cloudy lens forms a hazy degeneration in fundus images, making it challenging to observe patient’s vessels, which brings difficulties diagnosis process. To address this issue, paper establishes new image restoration method named Catintell. It contains synthesizing model,...
In order to develop potential glucosamine-6-phosphate synthase inhibitors and anti-fungal agents, twenty five oleanolic acid oxime esters were synthesized in an efficient way. The structures of the new compounds confirmed by MS, HRMS, 1H-NMR 13C-NMR. Preliminary studies based on means Elson-Morgan method indicated that many exhibited some inhibitory activity (GlmS), original fungicidal activities results showed good towards Sclerotinia sclerotiorum (Lib.) de Bary, Rhizoctonia solani Kuhn...
By constructing 2-(benzoylthio)benzoate and a 2-fluoro-4-nitrobenzoate structure in an adamantylidene-dioxetane system, we designed synthesized two novel chemiluminescent probes for the detection of H2Sn from other RSS. Under same conditions, maximum luminescence emission intensity probe CL-HP2 could reach 150 times that CL-HP1, chemiluminescence signal still existed at low concentrations. Therefore, was more suitable as probe. The exhibited good linear relationship with Na2S4 wide range...
This study aimed to develop and validate a prenatal cell-free DNA (cfDNA) screening method that uses capture-based enrichment genotype fetal autosomal recessive disorders. was applied in pregnancies at high risk of non-syndromic hearing loss (ARNSHL) assess its accuracy effectiveness.
In order to develop potential anti-fungal agents, seven glycoconjugates composed of a-L-rhamnose, 6-deoxy-a-L-talose, b-D-galactose, a-D-mannose, b-D-xylose-(1®4)-6-deoxy-a-L-talose, b-D-galactose-(1®4)-a-L-rhamnose, b-D-galactose-(1®3)-b-D-xylose-(1®4)-6-deoxy-a-L-talose as the glycone and oleanolic acid aglycone were synthesized in an efficient practical way using glycosyl trichloroacetimidates donors. The structures new compounds confirmed by MS, 1H-NMR 13C- NMR. Preliminary studies based...
Triazole pesticides are organic nitrogen-containing heterocyclic compounds, which contain 1,2,3-triazole ring. In order to develop potential glucosamine-6-phosphate synthase (GlmS) inhibitor fungicides, forty compounds of triazole derivatives were synthesized in an efficient way, thirty nine them new compounds. The structures all the confirmed by high resolution mass spectrometer (HRMS), ¹H-NMR and 13C-NMR. fungicidal activities results based on means mycelium growth rate method indicated...
Synthesis of two isomeric tetrasaccharides, β-D-Glup-(1→2)-α-L-Rhap-(1→3)-α-L- Rhap-(1→2)-α-L-Rhap (I) and β-D-Glup-(1→3)-α-L-Rhap-(1→3)-α-L-Rhap-(1→3)-α-L-Rhap (II), the repeating units from lipopolysaccharides nitrogen-fixing bacterium Azospirillum brasilense S17 lipoferum SR65, was achieved via assembly building blocks 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl trichloroacetimidate (2), p-methoxyphenyl 3,4-di-O-benzoyl-α-L-rhamnopyranoside (3),...
Abstract An iterative Ni‐catalyzed C( sp 3 )−C( ) cross‐coupling reaction of a novel cis ‐cyclopropane containing bifunctional building blocks with alkyl halides and Grignard reagents enabled the introduction cyclopropane ring into desired position(s) saturated carbon frameworks, providing straightforward synthetic route to fatty acids. The present method creates direct for construction can avoid tedious multistep operations based on unsaturated functional group manipulations that are often...
Abstract Currently, Bifidobacterium , Lactobacillus and Streptococcus thermophilus (BLS) are widely recognized as the crucially beneficial bacteria in gut. Many preclinical clinical studies have shown their protective effects against non‐alcoholic fatty liver disease (NAFLD). However, whether gestational BLS supplementation could alleviate NAFLD offspring is still unknown. Kunming mice were given a high‐fat diet (HFD) for 4 weeks before mating. They received by gavage during pregnancy. After...
Abstract This paper utilizes a correlation-based smart prediction model to construct teaching for mental health. In the ABaisSvd model, GD algorithm is used iteratively update matrix and optimize it by minimizing error between reconstructed achievement original matrix. The potential impact of attendance behavior bias factors on grade was also considered, function implemented optimized after analyzing correlation student grades, behavior, through dimensionality reduction. According analysis...
Abstract Background Adequate nutritional knowledge and healthy dietary behaviours are essential for promoting rational nutrition children. However, lack of unhealthy common among Chinese Therefore, we developed a school‐based education (NE) program to assess its impacts on in pupils. Methods In this trial, one school was assigned as an intervention group ( n = 199) the other two schools were designated control 140). Children received NE addition their regular health curriculum, whereas...
Cataract is one of the most common blinding eye diseases and can be treated by surgery. However, because cataract patients may also suffer from other diseases, ophthalmologists must diagnose them before The cloudy lens forms a hazy degeneration in fundus images, making it challenging to observe patient's vessels, which brings difficulties diagnosis process. To address this issue, paper establishes new image restoration method named Catintell. It contains synthesizing model, Catintell-Syn,...
Assessing changes in the intensity of biotic interactions across environmental gradients is a central issue ecology. The sentinel method has been widely adopted to study predator-prey by establishing patches prey under different conditions that predators can attack. Sentinels, proxies for prey, are frequently worm-shaped resembling caterpillars, with predation measured as rate disappearance or evidence after certain period exposure. While it suggested artificial might produce divergent...