A5062581593- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Nutrition and Health in Aging
- Advanced Glycation End Products research
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Renal and Vascular Pathologies
- Sodium Intake and Health
- Frailty in Older Adults
- Renin-Angiotensin System Studies
- Vitamin D Research Studies
- Clinical Nutrition and Gastroenterology
- Nutritional Studies and Diet
- Pharmacological Effects and Toxicity Studies
- Central Venous Catheters and Hemodialysis
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Bone health and treatments
- Body Composition Measurement Techniques
- Retinal Imaging and Analysis
- Fibroblast Growth Factor Research
- Health and Wellbeing Research
- Hormonal Regulation and Hypertension
- Health and Well-being Studies
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2015-2024
Società Italiana di Nefrologia
2024
Ospedale Maggiore
2015-2023
IRCCS Policlinico San Donato
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2017
University of Milan
2012
Azienda Ospedaliera San Gerardo
2009
Ospedale Bassini
2007
University of Genoa
2001-2006
Ospedale Policlinico San Martino
2005-2006
The role of serum uric acid as an independent risk factor for cardiovascular and renal morbidity is controversial. A better understanding its relationship with preclinical organ damage may help clarify the mechanism(s) implicated in development early disease. We evaluated association between presence degree target 425 (265 males, 160 females) middle-aged, untreated patients essential hypertension. Left ventricular mass index carotid intima-media thickness were assessed by ultrasound scan....
Background and objectives Left ventricular hypertrophy (LVH) abnormal left (LV) geometry predict adverse outcomes in the general hypertensive populations, but findings CKD are still inconclusive. Design, setting, participants, & measurements We enrolled 445 patients with hypertension stages 2–5 two academic nephrology clinics 1999–2003 who underwent both echocardiography ambulatory BP monitoring. LVH (LV mass >100 g/m2 [women] >131 [men]) relative wall thickness (RWT) were used to define LV...
Background: In patients with chronic kidney disease (CKD), sarcopenia can be determined by a wide spectrum of risk factors. We evaluated the association nutritional, behavioral and inflammatory patterns in older advanced CKD. Methods: we cross-sectionally 113 CKD stages 3b-5. Sarcopenia was defined according to EWGSOP2 criteria. assessed: anthropometry, bioelectrical impedance analysis, physical, psychological performance. Nutritional status assessed using Malnutrition Inflammation Score...
Background Frailty is common in older patients affected by chronic kidney disease (CKD). Since gut microbiota (gMB) may contribute to frailty, we explored possible associations between gMB and frailty CKD. Methods We studied 64 CKD (stage 3b-4), categorized as frail (F, 38) not (NF, 26) according Fried criteria, 15 controls (C), all than 65 years. In assessed serum C-reactive protein, blood neutrophil/lymphocyte ratio, Malnutrition-inflammation Score (MIS); was denaturing gel gradient...
Patients affected by chronic kidney disease (CKD) are generally considered to be frailer than those with preserved renal function. We cross-sectionally evaluated the associations between frailty, malnutrition–inflammation syndrome and circulating inflammatory cytokines in 115 older individuals advanced CKD. As for frailty definition, we adopted Fried’s phenotype (FP), while was assessed using Malnutrition–Inflammation Score (MIS) (IL-6; TNFα; MCP-1). A total of 48 patients were frail, mean...
Sarcopenia is a prevalent condition in chronic kidney disease (CKD). We determined gut microbiota (gMB) composition CKD patients with or without sarcopenia. Furthermore, we investigated whether these patients, there was any association between gMB, uremic toxins, inflammation and oxidative stress. analyzed gMB composition, toxins (indoxyl sulphate p-cresyl sulphate), inflammatory cytokines (interleukin 10, tumor necrosis factor α, interleukin 6, 17, 12 p70, monocyte chemoattractant protein-1...
The presence of mild renal dysfunction is associated with high cardiovascular morbidity and mortality rates in patients primary hypertension. pathophysiological mechanisms underlying this association are currently unknown. We investigated the relation between subclinical organ damage 358 never previously treated Mild was defined as a creatinine clearance <60 mL/min and/or microalbuminuria. Left ventricular mass index carotid intima-media thickness were assessed by ultrasound scan. prevalence...
Mild renal dysfunction (MRD) is an often overlooked but relatively common condition in patients with primary hypertension (PH), and associated high cardiovascular morbidity mortality. Whether MRD also abnormalities vascular resistance currently unknown.Two hundred ninety-one untreated PH were studied. The was defined as a creatinine clearance >or=60 mL/min <90 (Cockcroft-Gault formula) or the presence of microalbuminuria. Albuminuria measured albumin-to-creatinine ratio first morning urine...
<i>Introduction:</i> Increased renal vascular resistance and microalbuminuria are associated with hypertensive target organ damage may be predictors of nephrosclerosis. <i>Aim:</i> We investigated changes in resistive index (RI) urinary albumin excretion (UAE) a group patients primary hypertension before during long-term antihypertensive treatment. <i>Methods:</i> Thirty-two were randomized to receive treatment either calcium channel blocker (nifedipine...
Background Ultrasound (US) examination of heart and carotid arteries provides an accurate assessment target organ damage (TOD) may influence the stratification absolute cardiovascular risk profile. Microalbuminuria has recently proved to be a useful cost-effective marker increased but is still too often neglected in clinical practice. Objective To evaluate how well artificial neural networks (ANNs) predict by means routine data urinary albumin excretion, as compared prediction work-up...
Resistin is an adipokine that has been suggested to be correlated with markers of inflammation and predictive coronary atherosclerosis type II diabetes in humans. A common single nucleotide polymorphism (SNP) (-420C/G) the promoter resistin associated increased plasma levels susceptibility diabetes. The aim this study was investigate association -420C/G metabolic syndrome, obesity, myocardial infarction kidney disease.First we studied 1542 subjects from PLIC (a population based cohort). GG...
Advanced glycation end-products (AGE) can promote chronic kidney disease (CKD) progression and CKD-related morbidities. The soluble receptor for AGE (sRAGE) is a potential biomarker of inflammation oxidative stress. Here, we explored the role AGE, glycated albumin, sRAGE its different forms, cRAGE esRAGE, as prognostic factors mortality in 111 advanced CKD patients. median follow-up time was 39 months. were quantified by fluorescence, forms ELISA. Malnutrition screened Inflammation Score...
Older subjects with chronic kidney disease (CKD) are often affected by multiple geriatric impairments that may benefit from a comprehensive assessment (CGA). However, ordinary execution of CGA in all these individuals would be unaffordable. We evaluated if Frailty Phenotype (FP) could identify older CKD-patients the most CGA.We 112 CKD patients not yet on dialysis (age ≥ 65 years, eGFR < 45 ml/min). FP was defined according to criteria proposed Fried and co-authors. four domains (nutrition,...
Introduction: Recent randomized controlled trials have confirmed the ability of renal denervation to lower blood pressure (BP) in patients, resistant BP-lowering effect multiple antihypertensive drug administration. Evidence is limited, however, patients with end-stage disease (ESRD) and haemodialysis, a condition which persistent BP elevation, despite administration many drugs, common. Aim present study was test efficacy hypertension ESRD on haemodialysis. measured repeatedly office over 24...
Abstract Background Peritonitis is a common and severe complication of peritoneal dialysis (PD). For comparative analysis standardized definitions as well measurements outcomes are crucial. However, most PD-related peritonitis studies have been using heterogenous variable methods to measure outcomes. The ISPD 2022 guidelines revised clarified numerous proposed new categories Methods Between 1st January 2009 31st May 2023, 267 patients who started PD at our institution were included in the...