A5045294663- Posttraumatic Stress Disorder Research
- Child Abuse and Trauma
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Traumatic Brain Injury Research
- Psychotherapy Techniques and Applications
- Migration, Health and Trauma
- Psychological Treatments and Assessments
- Psychiatric care and mental health services
- Resilience and Mental Health
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Mental Health and Psychiatry
- Neuroendocrine regulation and behavior
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Health
- Medical Education and Admissions
- Evolutionary Psychology and Human Behavior
- Identity, Memory, and Therapy
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Treatment of Major Depression
- Autoimmune and Inflammatory Disorders
Leiden University
2017-2025
Parnassia Groep
2021-2025
Czech Academy of Sciences, Institute of Psychology
2024
Pro Persona
2013-2023
Radboud University Nijmegen
2010-2019
Background: Suboptimal response and high dropout rates leave room for improvement of trauma-focused treatment (TFT) effectiveness in ameliorating posttraumatic stress disorder (PTSD) symptoms.Objective: To explore the safety intensive prolonged exposure (iPE) targeting chronic PTSD patients with a likely diagnosis ICD-11 Complex following multiple interpersonal trauma history attempts.Method: Participants (N = 73) received iPE 12 × 90-minute sessions over four days (intensive phase) followed...
Background: It is unclear whether the evidence-based treatments for PTSD are as effective in patients with CA-PTSD.Objective: We aimed to investigate effectiveness of three variants prolonged exposure therapy.Method: recruited adults CA-PTSD. Participants were randomly assigned Prolonged Exposure (PE; 16 sessions weeks), intensified (iPE; 12 4 weeks followed by 2 booster sessions) or a phase-based treatment, which 8 PE preceded Skills Training Affective and Interpersonal Regulation...
Background: It has been proposed that maximizing expectancy violation enhances the efficacy of exposure therapy. The clinical utility remains unclear and it not yet studied in PTSD.
Anxiety-related disorders are characterized by high levels of avoidance, but experimental research into avoidance learning in patients is scarce. To fill this gap, we compared healthy controls (HC, n = 47) with obsessive-compulsive disorder (OCD, 33), panic agoraphobia (PDA, 40), and post-traumatic stress (PTSD, 66) a computer-based task, order to examine (1) differences rates responses, (2) action-safety during (3) subjective relief following successful avoidance. The task comprised...
Anxiety and related disorders are a significant public-health burden with rising prevalence in the wake of COVID-19 pandemic. As demand for effective anxiety treatment increases, so too does need strategies to bolster outcomes. Research on mechanisms exposure therapy, frontline behavioral treatment, will be critically important optimizing clinical We outline an initial agenda future research change developed collaboration large international team researchers through Exposure Therapy...
Many patients with post-traumatic stress disorder (PTSD) experience dissociative symptoms. The question of whether these symptoms negatively influence the effectiveness psychotherapy for PTSD is unresolved.To determine on outcome in PTSD.We conducted a systematic search Cochrane, Embase, PILOTS, PsycINFO, PubMed and Web Science relevant clinical trials. A random-effects meta-analysis examined impact dissociation (pre-registered at Prospero CRD42018086575).Twenty-one trials (of which nine...
Background: The Childhood Trauma Questionnaire (CTQ) is widely used, but retrospective self-report measures may be susceptible to bias especially in the context of pathology. Therefore, we aimed validate CTQ reduced psychopathology following trauma-focused treatment. Methods: We analyzed 149 outpatients with posttraumatic stress disorder (PTSD) related childhood abuse. Participants received one three variants prolonged exposure. was administered at baseline and six months later. internal...
Background The current study evaluated the effectiveness and safety of intensive prolonged exposure ( PE ) targeting adolescent patients with complex posttraumatic stress disorder PTSD comorbid disorders following multiple interpersonal trauma. Methods Ten adolescents meeting full diagnostic criteria for were recruited from a specialized outpatient mental health clinic offered standardized . consisted three daily 90‐min sessions delivered on five consecutive weekdays, followed by 3 weekly...
Background: Trauma-focused treatments (TFTs) for patients with post-traumatic stress disorder (PTSD) are highly effective, yet underused by therapists.Objective: To describe a new way of implementing (adequate use of) TFTs, using therapist rotation model in which one patient is treated several therapists.Method: In this article, we will present two examples working teams treatment settings TFT PTSD patients. We explore the experiences from both and perspective.Results: Our findings were...
One reason for the inclusion of Complex Posttraumatic Stress Disorder (CPTSD) in 11th revision International Classification Diseases (ICD-11) was its suspected relevance treatment indications. We investigated whether CPTSD predicted and moderated outcomes Prolonged Exposure (PE), intensified PE (iPE) Skills Training Affective Interpersonal Regulation followed by (STAIR + PE). expected that would predict worse across treatments. Secondly, we lead to better effect STAIR compared iPE.We...
Change in negative posttraumatic cognitions is a proposed mechanism through which Prolonged Exposure (PE) leads to symptom reduction of stress disorder (PTSD). A strong case for as change PTSD treatment can be made by establishing temporal precedence cognitions. The current study examines the relationship between and symptoms during PE, using Posttraumatic Cognitions Inventory. Patients with DSM-5 defined following childhood abuse (N = 83) received maximum 14-16 sessions PE. Clinician-rated...
Differences in effectiveness among treatments for posttraumatic stress disorder (PTSD) are typically small. Given the variation between patients treatment response, personalization offers a new way to improve outcomes. The aim of this study was identify predictors psychotherapy outcome PTSD and combine these into personalized advantage index (PAI). We used data from recent randomized controlled trial comparing prolonged exposure (PE; n = 48), intensified PE (iPE; 51), skills training...