To investigate if acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with myocardial injury, expressed as elevated high sensitive cardiac troponin T (hs-cTnT), and to identify determinants hs-cTnT in (COPD) patients.In a cross-sectional study, patients hospitalised for AECOPD was compared COPD their stable state.The study conducted at teaching rehabilitation clinic.Consecutive admissions participating units the years 2010-2011 meeting objective, standardised...

Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary (COPD). Cardiac troponin (cTn) elevation, indicating myocardial injury, frequent during acute COPD exacerbations and associated with increased mortality. The prognostic value of circulating cTnT among patients the stable state still unknown. purpose present study was to assess association between measured by high sensitive assay (hs-cTnT) all-cause mortality without overt CVD.In prospective cohort we...

Purpose: To explore the associations between sleep hypoventilation (SH) and daytime arterial pressures of carbon dioxide (P a CO 2 ), stages, apneas/hypopneas (AHI) in subjects with chronic obstructive pulmonary disease (COPD). SH has previously been found COPD-subjects hypercapnic respiratory failure (CHRF) using supplementary oxygen (LTOT), proposed as possible predictor for CHRF. Patients methods: A prospectively designed observational study rehabilitation hospital 100 (39 male) stable...

Abstract Obstructive sleep apnea (OSA) worsens outcomes in Chronic Pulmonary Disease (COPD), and reduced quality is common these patients. Thus, objective monitoring needed, but polysomnography (PSG) cumbersome costly. The WatchPAT determines by a pre-programmed algorithm has demonstrated moderate agreement with PSG detecting stages normal subjects OSA Here, we validated against COPD patients, hypothesizing line previous studies. 16 patients (7 men, mean age 61 years), underwent simultaneous...

Troponin is a biomarker of myocardial injury. In chronic obstructive pulmonary disease (COPD), troponin an important determinant mortality after acute exacerbation. Whether exacerbation COPD (AECOPD) causes elevation not known. Here, we investigated whether increased in AECOPD compared to stable COPD.We included 320 patients with the state and 63 random individuals from Akershus University hospital's catchment area. All participants were ≥40 years old (mean 65·1 years, SD 7·6) 176 (46%)...

Background: Excessive dynamic airway collapse (EDAC) represents pathologic obstruction, but the flow resistance it creates and possible impact on pulmonary function tests is unclear. Our aims were to explore in a model, patients relate observed EDAC tests. Methods: Model study: A garden hose was compressed from 1 side simulate posterior tracheal wall bulging into lumen for 2 lengths, 3 12 cm, 8 steps. Resistance measured at each step airflows L/s through 9 L/s. Digital photos of luminal area...

During acute exacerbation of chronic obstructive pulmonary disease (AECOPD), myocardial stress may be aggravated. Sparse data exist concerning the prevalence and correlates cardiac arrhythmias in stable exacerbated states COPD. We hypothesized that AECOPD is associated with increased independent COPD-severity co-morbidity, explored possible mechanisms. A 24-hour Holter recording was obtained 74 patients COPD 45 (mean age 54 years, 56% women). Any incidence supraventricular tachycardia (SVT),...

The purpose of this study is to explore the effect a moderate dose alcohol on sleep architecture and respiration in chronic obstructive pulmonary disease (COPD). Alcohol depresses both hypercapnic hypoxic ventilatory drives awake, normal individuals reduces amount rapid eye movement (REM) oxygen saturation (SpO2) sleeping COPD subjects.Prospectively designed, open-label interventional rehabilitation hospital. Twenty-six (nine males) stable inpatients, median forced expiratory volume first...

Poor sleep quality in chronic obstructive pulmonary disease (COPD) is a result of oxygen desaturation secondary to compromised lung function. Nitrate supplementation with dietary beetroot juice known elevate plasma nitrate and increase the efficiency utilization non-COPD individuals; whether it therapeutic benefit for COPD has not been reported.In counterbalanced within-subjects design involving 15 patients as subjects, subjects consumed either containing (BJ; ∼6.2 mmol NO3-) or placebo...

Abstract Background Cardiac troponin T (cTnT) is a biomarker of myocardial injury frequently elevated in COPD patients, potentially because hypoxemia. This non-randomised observational study investigates whether long-term oxygen treatment (LTOT) reduces the cTnT level. Methods We compared between patients who were candidates for LTOT (n = 20) with two reference groups. Patients from both groups matched index group using propensity score.Reference consists institutional pulmonary...

<b>Background:</b> Myocardial dysfunction may accompany acute exacerbations (AE) of COPD and contribute to poor outcome. One manifestation myocardial is cardiac arrhythmia. <b>Aims objectives:</b> To study determinants self-limiting tachy-arrhythmias in COPD, test the hypothesis that arrhythmias are more prevalent AECOPD, independent COPD-severity co-morbidity. <b>Methods:</b> A 24h Holter-registration was collected 74 patients with stable 45 AECOPD (mean age 54y, 56% women). Any...

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<b>Background:</b> Cardiovascular disease (CVD) is a common comorbidity in Chronic Obstructive Pulmonary Disease (COPD). Cardiac troponin elevation, indicating myocardial injury, frequent during acute COPD exacerbations and associated with increased mortality. The prognostic value of circulating cardiac T among patients the stable state still unknown. <b>Aims objectives:</b> To assess association between measured by high sensitive assay (hs-cTnT) all-cause mortality COPD. <b>Methods:</b> In...

Extreme physical exercise in healthy may be accompanied by low-level myocardial damage, as indicated elevations hs-cTnT. In stable COPD, hs-cTnT levels are higher than even at a resting state. <b>Aim:</b> To study if maximal cardiopulmonary test is associated with an increase level COPD patients. <b>Methods:</b> A prospective, observational pilot was performed on treadmill maximal, symptom limited CPET. 20 patients (50% men, age 65 (11) years) without signs of left heart failure and...

<b>Introduction:</b> At least&nbsp;half of Chronic Obstructive Pulmonary Disease (COPD) patients experience reduced sleep quality, and&nbsp;obstructive apnea (OSA)&nbsp;worsens outcomes. Thus, objective monitoring is often needed, but polysomnograpy costly and unavailable. The WatchPat^tm determines by a pre-programmed algorithm&nbsp;based on peripheral arterial tone, pulse rate, oxygen saturation, motor activity, snoring body position. In with OSA, the WatchPat demonstrated...

Abstract Introduction Chronic obstructive pulmonary disease (COPD) requires the use of accessory muscles to overcome inadequate ventilation. The activity these voluntary is compromised during sleep, resulting in insufficient ventilation, oxygen desaturation and disruption sleep. Nitrate supplementation with dietary beetroot juice (DBJ) known increase efficiency utilization non-COPD individuals; its therapeutic effect COPD uncertain. Methods In a repeated measured experiment involving 15...

<b>Background:</b> Pulmonary rehabilitation (PR) has well known positive effects on quality of life and physical performance in patients with COPD. PR is organized different ways. Although all PR-programs aim for sustained long-term effects, the beneficial tend to diminish time. Digital collection patient reported outcomes (PROMS) may be a feasible method follow up after PR. <b>Aims:</b> To evaluate feasibility collecting data through an online digital solution assessing 4-week inpatient...