A5013636591- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- Spectroscopy and Chemometric Analyses
- Immune Response and Inflammation
- Immune cells in cancer
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer Cells and Metastasis
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer Treatment and Pharmacology
- Caveolin-1 and cellular processes
- interferon and immune responses
University College Dublin
2014-2020
Charitable Infirmary
2014
Abstract Annually, ovarian cancer (OC) affects 240,000 women worldwide and is the most lethal gynecological malignancy. High‐grade serous OC (HGSOC) common aggressive subtype, characterized by widespread genome changes chromosomal instability consequently poorly responsive to chemotherapy treatment. The objective of this study was investigate role microRNA miR‐433 in cellular response cells paclitaxel We show that stable expression A2780 results induction senescence demonstrated...
Triple negative breast cancer (TNBC) is an aggressive subtype with relatively poor clinical outcomes and limited treatment options. Chemotherapy, while killing cells, can result in the generation of highly chemoresistant therapeutic induced senescent (TIS) cells that potentially form stem cell niches resulting metastases. Intriguingly, release significantly more extracellular vesicles (EVs) than non-senescent cells. Our aim was to profile EVs harvested from TIS TNBC compared control identify...
Here we report a preliminary study based on the application of Raman spectroscopy and surface enhanced (SERS) to investigate compositional differences between exosomes derived from ovarian carcinoma cells (cell line A2780) grown in normoxia (normal O<sub>2</sub> conditions) hypoxia (1% conditions). Exosomes are integral cell signalling, interest how communicate within their environment. We particularly interested identifying whether induced senescent can communi- cate via with neighbouring...
Despite the use of front-line anticancer drugs such as paclitaxel for ovarian cancer treatment, mortality rates have remained almost unchanged past three decades and majority patients will develop recurrent chemoresistant disease which remains largely untreatable. Overcoming chemoresistance or preventing its onset in first instance one major challenges research. In this study, we demonstrate a key link between senescence inflammation how complex network involving biomarkers MAD2, TLR4 MyD88...
1114 Background: TSG101 is an essential protein and constituent of cellular function involved in the sorting trafficking cell components destined for processing or degradation also integral to exosome production release. Limited information known about exosomes field breast cancer even less difficult treat subset triple-negative (TNBC). We propose that TNBC tumours demonstrating high levels are more likely recur locally at distant sites due enhanced mediated communication tumour...
Abstract Triple Negative Breast Cancers (TNBCs) are a histological subtype of breast tumors which innately hypoxic; tumor microenvironment integral to chemoresistance and aggressive behaviour. Importantly, hypoxia can drive viable cellular fate mechanisms rendering cancer cells capable by-passing apoptotic cell death when chemotherapeutically challenged. Moreover, exosomes (nanovesicles 40-150nm endocytic origin) preferentially released in the hypoxic environment potentially be trafficked...
Abstract Background: Women presenting with Triple Negative Breast Cancer (TNBC) have an increased risk of recurring at distant visceral metastatic sites such as brain, lungs and liver rather than bone compared to oestrogen-receptor-positive breast cancer. (Rakha et al., 2011, Wood 2004). The preferential homing TNBC cancer cells these is not clearly understood, but increasingly being attributed the ability extracellular vesicles (EVs) released by chemoresistant circulate creating niches...
Abstract Triple negative breast cancer (TNBC) is an aggressive subtype with relatively poor clinical outcomes and limited treatment options. Chemotherapy, while killing cells, can result in the generation of highly chemoresistant therapeutic induced senescent (TIS) cells that potentially form stem cell niches resulting metastases. Intriguingly, release significantly more extracellular vesicles (EVs) than non-senescent cells. Our aim was to profile EVs harvested from TIS TNBC compared control...