A5022913423- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Protease and Inhibitor Mechanisms
- Connective tissue disorders research
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Cell Adhesion Molecules Research
- Collagen: Extraction and Characterization
- Aortic aneurysm repair treatments
- MRI in cancer diagnosis
- Atrial Fibrillation Management and Outcomes
- Genetics and Neurodevelopmental Disorders
- Fetal and Pediatric Neurological Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Cerebrovascular and Carotid Artery Diseases
- Hemoglobinopathies and Related Disorders
- Infectious Encephalopathies and Encephalitis
- Glioma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- IgG4-Related and Inflammatory Diseases
- Amyotrophic Lateral Sclerosis Research
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Venous Sinus Thrombosis
- Ultrasound in Clinical Applications
Oulu University Hospital
2011-2024
University of Oulu
1999-2024
University of Helsinki
2011-2017
Keski-Pohjanmaan keskussairaala
2001-2003
Universität Ulm
1990
Warfarin use has rapidly increased with the aging of population. We investigated temporal trends in incidence and outcome warfarin-related intracerebral hemorrhages (ICHs) a defined population.We identified all subjects first-ever primary ICH during 1993 to 2008 among population Northern Ostrobothnia, Finland. The number warfarin users was obtained from national register prescribed medicines kept by Social Insurance Institution calculated annual ICHs, 28-day case fatality, deaths bleed.The...
<h3>Objective:</h3> To identify the incidence and predisposing factors for development of poststroke epilepsy (PSE) after primary intracerebral hemorrhage (PICH) during a long-term follow-up. <h3>Methods:</h3> We performed retrospective study patients who had their first-ever PICH between January 1993 2008 in Northern Ostrobothnia, Finland, survived at least 3 months. These were followed up PSE. The associations PSE occurrence sex, age, Glasgow Coma Scale (GCS) score on admission, hematoma...
Background Diffusion tensor imaging (DTI) enables measurements and visualization of the microstructure neural fiber tracts. The existing literature on autism spectrum disorders (ASDs) DTI is heterogenous both regarding methodology results. Purpose To compare brain white matter high-functioning individuals with ASDs controls. Material Methods Tract-based spatial statistics (TBSS), a voxel-based approach to DTI, was used 27 subjects (mean age 14.7 years, range 11.4–17.6 20 boys, 7 girls) 26...
Primary intracerebral hemorrhage (ICH) carries high morbidity and mortality rates. Several factors have been suggested as predicting the outcome. The value of C-reactive protein (CRP) levels in a poor outcome is unclear, findings contradictory. In their population-based cohort, authors tested whether, independent confounding factors, elevated CRP on admission (< 24 hours after ictus) are associated with an unfavorable outcome.The identified all patients who suffered primary ICH between 1993...
Background: Collagens are major proteins in the extracellular matrix, providing tissues with tensile strength. They also important for cell adhesion and invasion of malignant tumours. Methods: Thirty-nine samples human colon (24 diverticulosis, 6 tumours, 9 controls) were collected during elective surgery. Immunoassays different domains type I III collagens procollagens used soluble tissue extracts trypsin digests samples. Results: The contents cross-linked collagen telopeptides total...
The diagnosis of phyllodes tumors the breast is challenging due to many similarities with common fibroadenomas.To determine diagnostic accuracy core needle biopsy in diagnosing and analyze ultrasonographic (US) features fibroadenomas.From 1999 2003, 1010 lesions underwent imaging-guided biopsy. Of these, 57 fibroadenomas 12 were removed surgically. US results a total 64 (52 tumors) further analyzed, compared, correlated surgical histological results.The median sonographic sizes 3.2 cm 1.6...
Background and Purpose— Underlying comorbidities, previous strokes, medication may increase the risk for primary intracerebral hemorrhage (PICH) its recurrence. The aim of this study was to determine independent predictors recurrent PICH. Methods— We identified 961 subjects with first-ever PICH from 1993 2008 among population Northern Ostrobothnia, Finland. Hospital death records were reviewed data on drug use obtained national register prescribed medicines. Kaplan–Meier survival curves Cox...
The most common genetic cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) has been linked to a hexanucleotide repeat expansion in the C9ORF72 gene. frequency Finland is among highest world.We assessed 73 Finnish patients with FTLD order examine clinical characteristics associated expanded C9ORF72. Demographic features were evaluated. As potential disease modifier, apolipoprotein E (APOE) genotype was also assessed. Neuropathological analysis available...
A hexanucleotide expansion in chromosome 9 open-reading frame 72 (C9ORF72) has been found to be a major cause of frontotemporal lobar degeneration (FTLD). We describe 20-year follow-up unique case with very slowly progressive FTLD caused by the C9ORF72 repeat expansion. In serial neuropsychological examinations, patient’s cognitive decline was exceptionally slow and after 20 years patient still mainly independent activities daily living. Our indicates that there is great individual variation...
Malignant tumours often induce a fibroproliferative response in the adjacent stroma, characterized by increased expression of type I and III procollagens. In normal tissues, fibrillar collagens normally undergo extensive intermolecular cross-linking that provides tensile strength to tissue. Here we set out characterize collagen human ovarian carcinoma tissue vivo. Biochemical immunochemical methods were used for cross-linked telopeptides samples benign malignant serous tumours. The locations...
The extent of processing type III collagen is assessed, and the proportions I collagens are estimated in atherosclerotic plaques obtained from carotid artery, common femoral aorta. fraction that had retained its amino-terminal propeptide (pN-collagen) was 42% soluble extract but only 0.0081% insoluble residue. Taken together, 0.011% whole form pN-collagen. Together with small amounts free propeptides procollagen, this finding indicates a low rate turnover. solubilized telopeptides were...
Patients receiving oral anticoagulants run a higher risk of cerebral hemorrhage with poor outcome. Serotonin-modulating antidepressants (selective serotonin reuptake inhibitors [SSRIs], serotonin-norepinephrine [SNRIs]) are frequently used in combination warfarin, but it is unclear whether this drugs influences outcome after primary intracerebral (PICH). The authors investigated case fatality PICH among patients from defined population who were warfarin alone, aspirin, or...
Venous thromboembolism (VTE) after primary intracerebral hemorrhage (ICH) worsens patient prognosis. Administering low-molecular weight heparins (LMWH) to prevent VTE early (24 h) may increase the risk of hematoma enlargement, whereas administering late (72 onset decrease its effect on prevention. The authors investigated when it is safe and effective start LMWH in ICH patients.In setting double blinded, placebo controlled randomization, patients >18 years age with paretic lower extremity,...
Papillary lesions of the breast are considered diagnostically challenging for various reasons. A relatively high malignancy rate in final pathological analysis has many cases necessitated excision these lesions, regardless core needle biopsy (CNB).To assess mammographic, sonographic, and CNB findings papillary to correlate them with histology obtained by surgical excision.From 2000-2006, 29 benign 19 malignant tumors examined were surgically removed. Mammographic, results analyzed correlated...
Background Warfarin-associated intracerebral haemorrhage carries poor outcome due to rapid growth. Reversal of warfarin anticoagulation with prothrombin complex concentrate has been implemented as an acute treatment option for these subjects. Aim We investigated whether survival subjects warfarin-associated had improved after implementation reversal concentrate. Methods identified all during 1993–2008 among the population Northern Ostrobothnia, Finland. From 2004 onwards, was used in Oulu...
Diffusion tensor imaging (DTI) is a magnetic resonance (MRI) technique enabling visualization and measurement of white matter tracts. Attention deficit hyperactivity disorder (ADHD) has been studied with DTI earlier variable results, yet there little research on remitted ADHD.To compare the brain between ADHD drug naïve subjects whose symptoms have mostly subsided healthy controls.Tract-based spatial statistics (TBSS) was used to 30 adolescent control at age 22-23 years. The study population...
This study aimed to determine whether post-stroke epilepsy (PSE) predicts mortality, and describe the most prominent causes of death (COD) in a long-term follow-up after primary intracerebral hemorrhage (ICH).We followed 3-month survivors population-based cohort ICH patients Northern Ostrobothnia, Finland, for median 8.8 years. Mortality CODs were compared between those who developed PSE did not. was defined according ILAE guidelines. extracted from certificates (Statistics Finland).Of 961...
Neurosarcoidosis is a diagnostic challenge, especially if systemic symptoms are absent. We present 49-year-old woman with isolated neurosarcoidosis. The main symptom was loss of vision in the left eye. Brain MR imaging showed 6 high-signal white matter lesions frontotemporally on proton density and T2-weighted turbo spin-echo images. Coronal fat-saturated FLAIR images orbits swollen optic nerve increased signal intensity, which finding has not been previously published sarcoid neuropathy. A...
Purpose: To determine the incidence, operator's experience, and other variables that may influence development of pneumothorax or re-expansion edema after ultrasound (US)-guided thoracocentesis. Material Methods: The medical records 264 procedures in 212 patients who had undergone US-guided thoracocentesis our radiology department intensive care unit during period 1996-2001 were retrospectively reviewed. Results: Post-thoracocentesis occurred 11 cases, incidence being 4.2% (11/264). None...
Abstract Puumala hantavirus (PUUV) hemorrhagic fever with renal syndrome (HFRS) is common in Northern Europe; this infection usually self-limited and severe complications are uncommon. PUUV other hantaviruses, however, can rarely cause encephalitis. The pathogenesis of these rare events unknown. In study, we explored the possibility that genetic defects innate anti-viral immunity, as analogous to Toll-like receptor 3 (TLR3) mutations seen HSV-1 encephalitis, may explain We completed exome...