A5015026174- Microbial Natural Products and Biosynthesis
- Enzyme Catalysis and Immobilization
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Fungal Biology and Applications
- Sesquiterpenes and Asteraceae Studies
- Steroid Chemistry and Biochemistry
- Essential Oils and Antimicrobial Activity
- Retinoids in leukemia and cellular processes
- Chemical synthesis and alkaloids
- Phytochemistry and Biological Activities
- Microbial Metabolic Engineering and Bioproduction
- Synthetic Organic Chemistry Methods
- Hops Chemistry and Applications
- Vanadium and Halogenation Chemistry
- Marine Sponges and Natural Products
- Chronic Lymphocytic Leukemia Research
- Fungal Plant Pathogen Control
- Immunotoxicology and immune responses
- Microbial bioremediation and biosurfactants
- Erythrocyte Function and Pathophysiology
- Phytochemicals and Antioxidant Activities
- Crystallography and molecular interactions
- Environmental Chemistry and Analysis
- Insect Utilization and Effects
Wroclaw University of Environmental and Life Sciences
2015-2024
Medical University of Warsaw
2015
University of Agriculture in Krakow
2001-2006
University of Wrocław
2006
Institute of Haematology and Blood Transfusion
1992
Instytut Hematologii i Transfuzjologi
1991
The searching for biologically active compounds produced by living organisms led to the discovery of a number with more or less complicated structure. One simplest molecules are monoterpenoid lactones and loliolide is most common among them. Loliolide was found in animals (insects) plants (flowers, shrubs, trees) both terrestrial marine, such as algae corals. Many years research on used traditional folk medicine different countries have conclusion that this compound has variety biological...
The aim of this review is to present the potential application camphor—a bicyclic monoterpene ketone—in prevention skin infections. Skin diseases represent a heterogeneous group disorders characterized by prolonged symptoms that significantly diminish quality life. They affect dermis, epidermis, and even subcutaneous tissue. very often have bacterial or fungal background. Therapy for dermatological difficult long-term. Therefore, it important find compound, preferably natural origin, (i)...
The production of chiral sulphoxides is an important part the chemical industry since they have been used not only as pharmaceuticals and pesticides, but also catalysts or functional materials. main purpose this review to present biotechnological methods for oxidation sulfides. work consists two parts. In first part, examples biosyntransformation prochiral sulfides using whole cells bacteria fungi are discussed. They more historical significance due low predictability positive results in...
Ten new derivatives of isophorone were obtained through a five-step synthesis. Among the products several unsaturated, bicyclic lactones with three or four methyl groups. These used as substrates for biotransformation mediated by selected fungal strains (Fusarium species, Syncephalastrum racemosum, Cunninghamella japonica, Penicillium Absidia and Pleurotus ostreatus). Four hydroxylactones result biotransformation. Because unsaturated lactone groups was diastereoisomeric mixture, structural...
Eight new lactones (δ-chloro-, δ-bromo- and δ-iodo-γ-lactones), each with a methylcyclohexane ring, were obtained by chemical means from (4-methylcyclohex-2-en-1-yl) acetic acid or (6-methylcyclohex-2-en-1-yl) acid. Whole cells of ten fungal strains (Fusarium species, Syncephalastrum racemosum Botrytis cinerea) tested on their ability to convert these into other products. Some the transformed chloro-, bromo- iodolactone methyl group at C-5 2-hydroxy-5-methyl-9-oxabicyclo[4.3.0]nonan-8-one...
Duas lactonas bicíclicas com anéis gem-dimetilciclohexano (δ-bromo-γ-lactona e δ-iodo-γ-lactona) foram utilizadas como substratos para biotransformação por células inteiras de várias estirpes fúngicas (cinco Fusarium strains, Nigrospora oryzae, Syncephalastrum racemosum, Stemphylium botryosum Cunninghamella japonicae Acremonium sp).Alguns dos microorganismos selecionados (principalmente cepas Fusarium) transformam estas desalogenação hidrolítica em cis-...
Bicyclic chloro-, bromo- and iodo-γ-lactones with dimethylcyclohexane rings were used as substrates for bioconversion by several fungal strains (Fusarium, Botrytis Beauveria). Most of the selected microorganisms transformed these lactones hydrolytic dehalogenation into new compound cis-2-hydroxy-4,6-dimethyl-9-oxabicyclo[4.3.0]- nonan-8-one, mainly (-)-isomer. When iodo-γ-lactone was substrate, two products observed: a hydroxy-γ-lactone an unsaturated lactone. The structures all established...
Several fungal strains (Fusarium, Botrytis, Beauveria) were screened for their ability to transform three bicyclic halo-γ-lactones with a trimethylcyclohexane ring. Most of the micro-organisms carried out hydrolytic dehalogenation and transformed these lactones into two hydroxy-γ-lactones: cis (−)-2-hydroxy-4,4,6-trimethyl-9-oxabicyclo[4.3.0]nonan-8-one trans (+)-2-hydroxy-4,4,6-trimethyl-9-oxabicyclo[4.3.0]nonan-8-one. The structures all substrates products established on basis spectral...
α’-1’-Hydroxyethyl-γ-butyrolactone—a product of reduction α-acetylbutyrolactone possesses two stereogenic centres and reactive functionalities (an alcohol an ester group). Additionally, this compound has a similar structure to γ-butyrolactone (GBL) which is psychoactive. In the present work, biotransformation using seven yeast strains was used obtain anti stereoisomers α’-1’-hydroxyethyl-γ-butyrolactone. The process carried out in both growing resting culture. effect media composition...
The question being posed by scientists around the world is how different chemical modifications of naturally occurring compounds will affect their antimicrobial properties. In current study, sulfur derivatives camphor containing a atom were tested to detect and antibiofilm potentials. new on eight Gram-positive strains (S. aureus (3 isolates), S. epidermidis (4 E. faecalis (1 isolate)) Gram-negative (E. coli (6 A. baumannii isolate), P. aeruginosa isolate)). ability eradicate biofilm was...