The objective of this study was to evaluate the antimicrobial activity structural analogues xanthohumol 1, a flavonoid compound found in hops (Humulus lupulus). agar-diffusion method using filter paper disks applied. Biological tests performed for selected strains Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria, fungi (Alternaria sp.), yeasts (Rhodotorula rubra, Candida albicans) revealed that compounds with at least one hydroxyl group—all them have it C-4...

Abstract Chalcones are intermediate products in the biosynthesis of flavonoids, which possess a wide range biological properties, including antimicrobial and anticancer activities. The introduction chlorine atom glucosyl moiety into their structure may increase bioavailability, bioactivity, pharmacological use. combined chemical biotechnological methods can be applied to obtain such compounds. Therefore, 2-chloro-2′-hydroxychalcone 3-chloro-2′-hydroxychalcone were synthesized biotransformed...

There is an increasing demand for cost-effective and ecologically-friendly methods valorization of poultry feather waste, in which keratinolytic bacteria present a great potential. Feather-degrading were isolated from living single strain, identified as Kocuria rhizophila p3-3, exhibited significant properties. The bacterial strain effectively degraded up to 52% chicken feathers during 4 days culture at 25 °C. Zymographic analysis revealed the presence two dominating proteolytic enzymes...

The effects of agitation rates from 400 to 900 rpm and aeration ranging 0.18 0.6 vvm on biomass citric acid production glycerol media by acetate-negative mutants Yarrowia lipolytica, Wratislavia 1.31 AWG7, in batch culture were studied. 800 (at a constant rate 0.36 vvm) within the range 0.24-0.48 rpm), which generated dissolved oxygen concentration (DO) higher than 40%, found best for biosynthesis glycerol. An increase (higher rpm) had no impact DO production. highest (92.8 g/L) yield (0.63...

O-Alkyl derivatives of naringenin (1a–10a) were prepared from using the corresponding alkyl iodides and anhydrous potassium carbonate. The resulting products used to obtain oximes (1b–10b). All compounds tested for antimicrobial activity against Escherichia coli ATCC10536, Staphylococcus aureus DSM799, Candida albicans DSM1386, Alternaria alternata CBS1526, Fusarium linii KB-F1, Aspergillus niger DSM1957. biological was expressed as increase in optical density (ΔOD). highest inhibitory...

The progress of research on silver nanoparticles (AgNPs) has led to their inclusion in many consumer products (chemicals, cosmetics, clothing, water filters, and medical devices) as a biocide. Despite the widespread use AgNPs, biocidal activity is not yet fully understood usually associated with various factors (size, composition, surface, red-ox potential, concentration) and, obviously, specific features microorganisms. There are merely few studies concerning interaction molds AgNPs....

Plants from the Ilex genus are known for properties such as antimicrobial and anti-inflammatory activity, can act antiobesity agents thus be helpful in medicine. Some holly species, paraguariensis (widely form of popular beverage: yerba mate), have been investigated, while others partially researched or remain unknown. Therefore, we performed qualitative quantitative phytochemical analyses screened lesser-studied species (I. aquifolium L., I. 'Argentea Marginata' × meserveae 'Blue Angel')....

The aim of the study was to obtain alginate oligosaccharides by using two degradation methods sodium (SA): with hydrochloric acid (G—guluronate, M—mannuronate and G + M fractions) hydrogen peroxide (HAS—hydrolyzed SA), in order assess compare their biological activity physico-chemical properties, an attempt produce gels from obtained hydrolysates. efficiency each method determined select fastest most efficient process. ferric ion reducing antioxidant power (FRAP), ability scavenge DPPH free...

The aims of this study were to obtain chitooligosaccharides (COS) from chitosan (CH) with improved functional properties and comparison the use two different enzymes: commercial cellulase (CL) dedicated enzyme chitosanase (CS). After enzymatic reaction, oligomers (NFs) isolated by methanol into fractions: precipitate (HMF) supernatant (LMF). occurrence a hydrolysis reaction was confirmed an increased reducing sugar content viscosity reduction oligomers. CPMAS 13C NMR analysis dissimilar...

A series of 18 aminochalcone derivatives were obtained in yields 21.5-88.6% by applying the classical Claisen-Schmidt reaction. Compounds 4-9, 14 and 16-18 with 4-ethyl, 4-carboxy-, 4-benzyloxy- 4-benzyloxy-3-methoxy groups novel, not previously described scientific literature. To determine biological properties synthesized compounds, anticancer antimicrobial activity assays performed. Antiproliferative potential was evaluated on four different human colon cancer cell lines-HT-29, LS180,...

Six γ-oxa-ε-lactones, 4-phenyl-3,4-dihydro-2H-1,5-benzodioxepin-2-one (5a) and its five derivatives with methoxy groups in different positions of A B rings (5b-f), were synthesized from corresponding flavanones. Three the obtained lactones (5b,c,f) have not been previously described literature. Structures all compounds confirmed by complete spectroscopic analysis assignments signals on 1H 13C-NMR spectra to atoms. In most cases, 5a-f exerted an inhibitory effect growth selected pathogenic...

Biotransformations are an alternative method of receiving dihydrochalcones as a result the reduction α,β-unsaturated ketones - chalcones. In presented research, two strains bacteria Gordonia sp. DSM44456 and Rhodococcus DSM364 were selected effective biocatalysts that able to transform chalcones in short period time. As our investigation 3 new one novel alcohol obtained with high isolated yields. All 4'-methylchalcone derivatives biotransformations products tested for antimicrobial activity...

Ten new derivatives of isophorone were obtained through a five-step synthesis. Among the products several unsaturated, bicyclic lactones with three or four methyl groups. These used as substrates for biotransformation mediated by selected fungal strains (Fusarium species, Syncephalastrum racemosum, Cunninghamella japonica, Penicillium Absidia and Pleurotus ostreatus). Four hydroxylactones result biotransformation. Because unsaturated lactone groups was diastereoisomeric mixture, structural...

Eight new lactones (δ-chloro-, δ-bromo- and δ-iodo-γ-lactones), each with a methylcyclohexane ring, were obtained by chemical means from (4-methylcyclohex-2-en-1-yl) acetic acid or (6-methylcyclohex-2-en-1-yl) acid. Whole cells of ten fungal strains (Fusarium species, Syncephalastrum racemosum Botrytis cinerea) tested on their ability to convert these into other products. Some the transformed chloro-, bromo- iodolactone methyl group at C-5 2-hydroxy-5-methyl-9-oxabicyclo[4.3.0]nonan-8-one...

Duas lactonas bicíclicas com anéis gem-dimetilciclohexano (δ-bromo-γ-lactona e δ-iodo-γ-lactona) foram utilizadas como substratos para biotransformação por células inteiras de várias estirpes fúngicas (cinco Fusarium strains, Nigrospora oryzae, Syncephalastrum racemosum, Stemphylium botryosum Cunninghamella japonicae Acremonium sp).Alguns dos microorganismos selecionados (principalmente cepas Fusarium) transformam estas desalogenação hidrolítica em cis-...

Hydrolysis of brewers' spent grain conducted in the bacterial cultures entails reduction workload, economic cost and environmental impact.

1. Stability of Dry and Liquid Metschnikowia pulcherrima Formulations for Biocontrol Applications against Apple Postharvest Diseases Andreas Bühlmann, Sandrine Kammerecker, Laurin Müller, Maja Hilber-Bodmer, Sarah Perren, Florian Freimoser Horticulturae CrossRef