A5086764346- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease and Spinal Disorders
- Sleep and Wakefulness Research
- Neurological and metabolic disorders
- Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neuropharmacology Research
- Glycogen Storage Diseases and Myoclonus
- Neurological diseases and metabolism
- Schizophrenia research and treatment
- Restless Legs Syndrome Research
- Trigeminal Neuralgia and Treatments
- Streptococcal Infections and Treatments
- Epilepsy research and treatment
- Facial Nerve Paralysis Treatment and Research
- Banana Cultivation and Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Psychology and Mental Health
- Nuclear Receptors and Signaling
- Neurology and Historical Studies
- Neurotransmitter Receptor Influence on Behavior
Hospital Israelita Albert Einstein
2005-2022
Associação Paulista de Medicina
1985-2009
Albert Einstein College of Medicine
2009
Hospital São Paulo
2008
Universidade Federal de São Paulo
1995-2006
Insper
2005
Hospital do Servidor Público Estadual
1998-2004
Hospital do Servidor Público Municipal
2003
Fundação de Apoio à Universidade Federal de São Paulo
1998
European Automobile Manufacturers Association
1995
Manganese (Mn) poisoning, a well-known hazard in miners and industrial workers, shares many features with Parkinson9s disease. Two young agricultural workers parkinsonian syndrome, who mentioned exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate), led us investigate new possible source of Mn intoxication. Fifty male rural occupational were compared 19 without exposure. We noted significantly higher prevalence plastic rigidity cogwheel phenomenon, headache, fatigue,...
Abstract Konstantin Tretiakoff's doctoral dissertation “Contribution a l'Etude de L'Anatomie pathologique du Locus Niger Soemmering avec quelques déductions relatives à la pathogénie des troubles tonus musculaire et De La Maladie Parkinson” (A Study of the Pathological anatomy locus niger Soemerring and its relevance to pathogenesis changes in muscular tone Parkinson's disease) published 1919 earned him silver medal awarded by University Paris but failed gain recognition importance deserved....
The treatment of Parkinson's disease (PD) is challenging, especially since it considered highly individualized. Brazilian Academy Neurology has recognized the need to disseminate knowledge about management PD treatment, adapting best evidence reality. Thus, main published guidelines were reviewed based on recommendations group from Movement Disorders Scientific Department Neurology.
Abstract Early‐onset Parkinson's disease (EOPD) is distinct from the classic late‐onset PD (LOPD) because of its slower progression. The aim this study was to compare dopamine neuronal loss in EOPD with that LOPD same duration, through transporter (DAT) estimation. Fourteen patients, seven (<50 years) and LOPD, matched for duration were scanned [ 99m Tc]‐TRODAT‐1‐SPECT (INER‐Taiwan), assessed standard scales. patients had 34% lower striatal DAT binding potential (BP) compared (BP = 0.29 ±...
Voice and speech disorders are common in Parkinson's disease patients may lead to social isolation. We employed routine clinical voice therapy measures evaluate the effect of rehabilitation. Twenty with a stable drug regimen participated this study. The were assessed before after program rehabilitation consisting 13 group sessions during 1 month, emphasis on increase laryngeal sphincteric activity. produced an maximal phonation times, decrease values s/z ratio air flow, vocal intensity,...
Doze pacientes com doença de Parkinson (DP) foram submetidos a privação sono total. A média idade dos era 61 anos e duração da em 5,1 (1,5 12 anos). Quatro deles usavam apenas anticolinérgico, 4 L-Dopa combinação drogas ambos os grupos. Após total por uma única noite foi verificada melhora na rigidez, bradicinesia, alterações postura marcha incapacidade funcional duas semanas, comparação escores quando inclusão no estudo. Não observado efeito sobre o tremor. Em relação aos sintomas...
Abstract LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy‐body pathology at post‐mortem. Studies of olfaction in are sparse incongruent. We applied a previously validated translation the 16 item smell identification test from Sniffin' Sticks (SS‐16) to 14 parkinsonian carriers heterozygous G2019S mutation compared 106 PD patients 118 healthy controls. The mean SS‐16 score was higher than ( p < 0.001, 95% CI for β = −4.7 −1.7) lower controls 0.007, +0.6...
ABSTRACT: Dystonia is a syndrome characterized by sustained muscle contraction, provoking twisting and repeti-tive movements or abnormal postures. It may be classified according to etiology, as idiopathic symptomatic. We studied 122 Brazilian patients with dystonic syndrome. Of these, 46 (37.7%) had symptomatic dystonia. The most frequent cause was tardive dystonia (34.8%) followed perinatal cerebral injury (30.4%). Other causes were stroke (13.0%), encephalitis (6.5%) Wilson’s disease...
Investigação prévia mostrou que ratos privados de sono (REM SD) mostram acentuação resposta a agonistas dopaminérgicos. As evidências indicam essa ação parece ser mediada por supersensibilização receptores dopaminérgicos pós-sinápticos. Com base nisso, foi feita REM SD em com modelo experimental da doença Parkinson, nos quais lesão eletrolítica bilateral ambas as vias nigro-estriatais. Sete dias após cirurgia os animais eram submetidos 72 horas. Imediatamente o final deste período era...
Cephalic tetanus is a localized form of tetanus. As in generalized forms , trismus prominent feature the disease, leading to considerable difficulty feeding, swallowing saliva and mouth hygiene. These difficulties often precede respiratory problems aspiration bronchopneumonia frequent life-threatening complication. Muscle relaxants other than curare drugs may show limited benefit for relieving trismus. Tetanospasmin, tetanic neurotoxin, botulinum toxin share many similarities, having closely...
Abstract Data on the frequency of PINK1 mutations in Brazilian patients with early‐onset Parkinson's disease (EOPD) are lacking. The aim this report was to investigate gene a cohort EOPD. Sixty consecutive familial or sporadic EOPD were included. All eight exons and exon‐intron boundaries analyzed. We did not find any pathogenic mutation our cohort. Single Nucleotide Polymorphisms (SNP) identified 46.7% 45.9% controls ( P = 0.9). SNPs had already been described previous reports. results...
A presença de tremor e distonia torção no mesmo paciente é frequente mas não há uma explicação satisfatória para isso. Suspeita-se que haja associação da idiopática (DI) com o essencial (TE). O objetivo deste estudo analisar a frequência postural das mãos em pacientes DI sintomática (DS). Foram estudados os prontuários 185 diagnóstico sindrômico atendidos Setor Investigação Moléstias Extrapiramidais Escola Paulista Medicina. foi diagnosticada quando havia anormalidade exame neurológico além...
Este artigo contém as conclusões de reunião 17-18 novembro 2006 do Grupo Brasileiro Estudo em Síndrome das Pernas Inquietas (GBE-SPI) sobre diagnóstico e tratamento SPI. Reiterou-se que se trata condição exclusivamente clínico, caracterizada por sensação anormal localizada, sobretudo, mas não exclusivamente, membros inferiores, com piora noturna alívio movimentação da parte envolvida. Agentes terapêuticos eficácia comprovada estudos classe I são agonistas dopaminérgicos, levodopa gabapentina...
Dystonia may be classified by age of onset (childhood, adolescence, adult onset), body distribution the abnormal movements (focal, segmental, unilateral, multifocal and generalized) etiology (idiopathic symptomatic). We studied 76 patients with idiopathic dystonia among 122; cases dystonic syndrome (62.3% total). There were 48 female 28 male patients. Adult-onset focal was most frequent feature (37 patients). The generalized more frequently seen under 20, whereas segmental usually started...
Patients with Parkinson’s disease (PD) manifest visual losses. However, it is not known whether these losses are equivalent in both early-onset (EOPD) and late-onset (LOPD) patients. We evaluated contrast sensitivity color vision EOPD LOPD patients age-matched controls. Losses occurred patient groups but were more pronounced EOPD, consistent the notion that non-motor symptoms affected by age of symptom onset. More studies function needed to understand how aging related pathophysiology PD...
Although the precise etiology of Parkinson's disease (PD) is as yet unknown, it appears that certain environmental factors are involved. Prior living in a rural area has been implicated possible risk factor for PD, particularly early onset type. We evaluated role previous conditions clinical correlates and outcome characteristics 118 PD patients. All them were seen from January 1987 to October 1992. The Rural Group (RG) comprised 71 patients (60.2%) who had lived at least 10 years (mainly...