A5091541606- Bacterial Genetics and Biotechnology
- Protein Structure and Dynamics
- Bacteriophages and microbial interactions
- Mediterranean and Iberian flora and fauna
- Enzyme Structure and Function
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Chemical Synthesis and Analysis
- DNA Repair Mechanisms
- Stress and Burnout Research
- Finance, Taxation, and Governance
- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- RNA Interference and Gene Delivery
- Historical and socio-economic studies of Spain and related regions
- DNA and Nucleic Acid Chemistry
- Data Privacy and Cybersecurity
- Advanced biosensing and bioanalysis techniques
- Antimicrobial Peptides and Activities
- Employment, Labor, and Gender Studies
- Economic and Social Development
- Vasculitis and related conditions
- Bluetooth and Wireless Communication Technologies
- Digital Communication and Language
- Microbial Natural Products and Biosynthesis
Memorial Sloan Kettering Cancer Center
2020
Cornell University
2017
Consejo Superior de Investigaciones Científicas
2007-2010
Instituto de Química Física Blas Cabrera
2007-2010
Abstract The widespread application of high-throughput sequencing methods is resulting in the identification a rapidly growing number novel gene fusions caused by tumour-specific chromosomal rearrangements, whose oncogenic potential remains unknown. Here we describe strategy that builds upon recent advances genome editing and combines ex vivo engineering to effectively interrogate genomic rearrangements identified human brain cancers. We show one such rearrangement, an microdeletion fusion...
Abstract Incorporation of disulfide bonds to stabilize protein and peptide structures is not always a successful strategy. To advance current knowledge on the contribution β‐hairpin stability, previously reported β‐hairpin‐forming was taken as template design series Cys‐containing peptides. The conformational behavior these peptides in their oxidized, disulfide‐cyclized peptides, reduced, linear investigated basis NMR parameters: NOEs, 1 H 13 C chemical shifts. We found that effect stability...
Direct targeting of critical DNA-binding elements a repressor by its cognate antirepressor is an effective means to sequester the and remove transcription initiation block. Structural descriptions for this, though often proposed bacterial phage repressor–antirepressor systems, are unavailable. Here, we describe structural functional basis how Myxococcus xanthus CarS recognizes neutralizes repressors turn on photo-inducible promoter. CarA CarH repress carB operon in dark. CarS, produced...
TA0095 is a 96-residue hypothetical protein from Thermoplasma acidophilum that exhibits no sequence similarity to any of known structure. Also, member the COG4004 orthologous group unknown function found in Archaea bacteria. We determined its three-dimensional structure by NMR methods. The displays an alpha/beta two-layer sandwich architecture formed three alpha-helices and five beta-strands following order beta1-alpha1-beta2-beta3-beta4-beta5-alpha2-alpha3. Searches for structural homologs...