A5078283032- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Adenosine and Purinergic Signaling
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Neonatal Health and Biochemistry
- vaccines and immunoinformatics approaches
- HIV/AIDS drug development and treatment
- Bacterial Genetics and Biotechnology
- Cytomegalovirus and herpesvirus research
- Alzheimer's disease research and treatments
- Peptidase Inhibition and Analysis
- Aquaculture disease management and microbiota
- Memory and Neural Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Ruminant Nutrition and Digestive Physiology
- RNA and protein synthesis mechanisms
- Amino Acid Enzymes and Metabolism
- Rabbits: Nutrition, Reproduction, Health
- Chemical Synthesis and Analysis
- Molecular Sensors and Ion Detection
- Animal Virus Infections Studies
- Turtle Biology and Conservation
- CRISPR and Genetic Engineering
- Calcium signaling and nucleotide metabolism
Universidad de Murcia
1996-2023
Consejo Superior de Investigaciones Científicas
2010
Unidades Centrales Científico-Técnicas
2010
Hebrew University of Jerusalem
2000-2004
Zero to Three
2004
Herzog Hospital
2000
Baylor College of Medicine
2000
Acute stress increases the risk for neurodegeneration, but molecular signals regulating shift from transient responses to progressive disease are not yet known. The "read-through" variant of acetylcholinesterase (AChE-R) accumulates in mammalian brain under acute stress. Therefore, markers neurodeterioration were examined transgenic mice overexpressing either AChE-R or "synaptic" AChE variant, AChE-S. Several observations demonstrate that excess attenuates, whereas AChE-S intensifies,...
Abstract Protein levels of different acetylcholinesterase (AChE) splice variants were explored by a combination immunoblot techniques, using two antibodies, directed against the C‐terminus AChE‐R variant or core domain common to all variants. Both and AChE‐S as well several heavier AChE complexes detected in brain homogenates from parietal cortex patients with without Alzheimer's disease (AD) cerebrospinal fluid (CSF) AD patients, compatible assumption that CSF AChEs might originate CNS...
Studies of knockout (KO) mice with defects in the endolysosomal two-pore channels (TPCs) have shown TPCs to be involved pathophysiological processes, including heart and muscle function, metabolism, immunity, cancer, viral infection. With objective studying TPC2's roles for first time a large, more humanlike animal model, TPC2 KO pigs were produced using CRISPR-Cas9. A major problem CRISPR-Cas9 edit embryos is mosaicism; thus, we studied effect microinjection timing on mosaicism. Mosaicism...
Direct targeting of critical DNA-binding elements a repressor by its cognate antirepressor is an effective means to sequester the and remove transcription initiation block. Structural descriptions for this, though often proposed bacterial phage repressor–antirepressor systems, are unavailable. Here, we describe structural functional basis how Myxococcus xanthus CarS recognizes neutralizes repressors turn on photo-inducible promoter. CarA CarH repress carB operon in dark. CarS, produced...
European eel is critically endangered in Europe. Among other stressors, pathogens are well-known to harm eels' fitness. One hundred and eighty-two eels were captured three Eel Management Units Andalucía (SE Spain) analysed for Anguillicoloides crassus, Anguillid herpesvirus 1 (AngHV1), the rhabdovirus Virus X (EVEX) aquabirnavirus (EVE). A. crassus adults preadults isolated morphometrically identified, swimbladders artificially digested count larvae. Also, tissues examined by PCRs presence...
Developmental and trauma-induced mechanism(s) that modify inflammation immune responses in blood cells were recently found to be regulated by acetylcholine. Here, we report corresponding cell-specific changes acetylcholinesterase splice variants. Plasmon resonance flow cytometry using variant-specific antibody probes, revealed a progressive increase myeloid cell fractions expressing the apoptosis-related acetylcholinesterase-S variant from newborns adult controls post-delivery mothers....
During the COVID-19 pandemic caused by SARS-CoV-2, new waves have been associated with variants and potential to escape vaccinations. Therefore, it is useful conduct retrospective genomic surveillance research. Herein, we present a detailed analysis of 88 SARS-CoV-2 genomes belonging samples taken from patients October 2020 April 2021 at "Reina Sofía" Hospital (Murcia, Spain) focused variant appeared later. The results mentioned stage show turning point since 20E (EU1) was still prevalent...
Conference Article| August 01 1997 5′-Nucleotidase in mouse muscle is a zinc-containing protein Alejandro MARTÍNEZ-MARTÍNEZ; MARTÍNEZ-MARTÍNEZ 1Dpto. Bioquímica y Biología Molecular-A. Edif. Veterinaria, Univ. Murcia, Apdo. 4021, 30071, Spain. E. mail: cevidal@fcu.um.es Search for other works by this author on: This Site PubMed Google Scholar Cesar FLORES-FLORES; FLORES-FLORES Encarnación MUÑOZ-DELGADO; MUÑOZ-DELGADO Cecilio J. VIDAL Biochem Soc Trans (1997) 25 (3): 382S....
Cuarenta y dos cabras jóvenes con un promedio de año edad 22.352 kg peso, se dividieron al azar en tres tratamientos 14 cada uno, el fin de: 1) evaluar niveles pollinaza, como parte del suplemento para acelerar la entrada primer empadre las pastoreo extensivo, a través incrementos 2) determinar mejor nivel pollinaza suplemento, tasas preñez, partos prolificidad. Por 45 días (33 antes 12 durante mismo) estuvo suplementando pollinaza. En tratamiento proporciona 30% (P) 70% grano sorgo (S);...