A5056626219- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Medical Imaging Techniques and Applications
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Mitochondrial Function and Pathology
- Neonatal Health and Biochemistry
- Nerve injury and regeneration
- Neurological and metabolic disorders
- Peroxisome Proliferator-Activated Receptors
- Heme Oxygenase-1 and Carbon Monoxide
- Radioactive Decay and Measurement Techniques
- Porphyrin Metabolism and Disorders
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Restless Legs Syndrome Research
Universidad de Navarra
2015-2022
Clinica Universidad de Navarra
2011-2022
Biomedical Research Networking Center on Neurodegenerative Diseases
2015
Porphobilinogen deaminase (PBGD) haploinsufficiency (acute intermittent porphyria, AIP) is characterized by neurovisceral attacks when hepatic heme synthesis activated endogenous or environmental factors including fasting. While the molecular mechanisms underlying nutritional regulation of have been described, glucose homeostasis during fasting poorly understood in porphyria. Our study aimed to analyse and carbohydrate metabolism PBGD-deficient mice. To determine contribution PBGD deficiency...
Dopaminergic denervation in patients with Parkinson's disease is associated changes brain metabolism. Cerebral in-vivo mapping of glucose metabolism has been studied severe stable parkinsonian monkeys, but data on metabolic early stages dopaminergic depletion this model lacking. Here, we report cerebral progressive nigrostriatal lesion the pre-symptomatic and symptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkey Disease. Monkeys (Macaca fascicularis) received MPTP injections...