A5047699420- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Indoor Air Quality and Microbial Exposure
- Energy and Environment Impacts
- French Urban and Social Studies
- Agriculture and Rural Development Research
- Pesticide Exposure and Toxicity
- Conservation, Biodiversity, and Resource Management
- Mycotoxins in Agriculture and Food
- Occupational Health and Performance
- African Studies and Ethnography
- Climate Change and Health Impacts
- Neuroscience and Neuropharmacology Research
- Air Quality Monitoring and Forecasting
- DNA and Nucleic Acid Chemistry
- Odor and Emission Control Technologies
- DNA Repair Mechanisms
- Environmental Toxicology and Ecotoxicology
- Vehicle emissions and performance
- Circadian rhythm and melatonin
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Safe Handling of Antineoplastic Drugs
- Agricultural safety and regulations
Aliments Bioprocédés Toxicologie Environnements
2006-2023
Université de Caen Normandie
2005-2022
Normandie Université
2013-2022
Université de Rouen Normandie
2018-2022
Centre François Baclesse
1995-2022
University of California, Los Angeles
2008-2013
Aménagement, Développement, Environnement, Santé et Sociétés
2003-2006
Centre National de la Recherche Scientifique
2006
Université de Bordeaux
2006
La Rochelle Université
2002
In Huntington's disease (HD) mouse models, spontaneous inhibitory synaptic activity is enhanced in a subpopulation of medium-sized spiny neurons (MSNs), which could dampen striatal output. We examined the potential source(s) increased inhibition using electrophysiological and optogenetic methods to assess feedback feedforward two transgenic models HD. Single whole-cell patch-clamp recordings demonstrated that GABA impinges principally on indirect pathway MSNs. Dual patch between MSNs reduced...
Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine (especially by Khanty people) to treat various health problems. In this study, we aimed quantify the 3 metabolites frequently cited literature, that is, betulin, betulinic acid, inotodiol Chaga recently discovered forests located Normandy (France), compare their concentrations with Ukrainian Canadian Chaga. This study explores cytotoxicity of French against cancer-derived cells...
To extend current knowledge on the underlying mechanisms of air pollution particulate matter (PM(2.5))-induced human lung toxicity, metabolic activation polycyclic aromatic hydrocarbons (PAH) within PM(2.5) and PAH-DNA bulky stable adduct patterns in alveolar macrophage (AM) and/or epithelial L132 cells mono- cocultures were studied. In coculture system, only AM exposed to PM(2.5), unlike cells. Particles, inorganic fraction positive controls [i.e. TiO(2), thermally desorbed PM (dPM)...
Epidemiological studies have demonstrated the link between chronic exposure to particulate matter (PM), especially particles with an aerodynamic diameter lesser than 2.5 µm (PM(2.5) ), and lung cancer. Mechanistic investigations focus on contribution of various genotoxicants adsorbed onto particles, more particularly polycyclic aromatic hydrocarbons or nitroaromatics. Most previous dealing genotoxic and/or mutagenic measurements were performed organic extracts obtained from PM(2.5) collected...
Airborne particulate matter (PM) toxicity is of growing interest as diesel exhaust particles have been classified carcinogenic to humans. However, PM a mixture chemicals, and respective contribution organic inorganic fractions remains unclear. Thus, we analysed the link between chemical composition samples bulky DNA adduct formation supported by CYP1A1 1B1 genes induction catalytic activities. We used six native samples, collected in industrial, rural or urban areas, either during summer...
For some years, the degradation of homes by dry rot fungus Serpula lacrymans increased. This study described, for first time, fungal contamination in located Low–Normandy (France) and damaged lacrymans. Wood–decaying fungi, airborne molds, species growing on building materials were investigated cultural molecular methods. Mycotoxins air quantified HPLC–MS/MS mutagenicity aerosols was also evaluated using Ames test. The results showed that detected one third with sometimes co–occurrence other...
To determine haematological parameters, urine mutagenicity (on three Salmonella typhimurium strains), and DNA damage (using the comet assay) in mononuclear leucocytes of farmers before after a one-day spraying period pear apple trees with fungicide captan usual conditions.Fruit growers were exposed to during 1998 (n = 12) and/or 2000 seasons 17). Biological samples collected on morning day (S1), evening (S2), (S3). The UK Predictive Operator Exposure Model (UK-POEM) was used quantify...
Pyrotechnic smokes are widely used in civilian and military applications. The major issue arise from the release of particles after smoke combustion but health risks related to their exposure poorly documented whereas toxicity airborne on respiratory target very well known. Therefore, this study aimed explore vitro particle fraction different pyrotechnic smokes. Particles a red signalling (RSS), an hexachloroethane-based obscuring (HC-OS) anti-intrusion (AIS) were collected cloud. RSS...