A5072433146- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- Protein Hydrolysis and Bioactive Peptides
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 diagnosis using AI
- Insect Resistance and Genetics
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Cardiac Fibrosis and Remodeling
- Blood Coagulation and Thrombosis Mechanisms
- Blood disorders and treatments
- Platelet Disorders and Treatments
Vall d'Hebron Institut de Recerca
2020-2023
Vall d'Hebron Hospital Universitari
2020-2023
Universitat Autònoma de Barcelona
2020
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2020
Instituto de Salud Carlos III
2020
Banc de Sang i Teixits
2018
Large studies in von Willebrand disease patients, including Spanish and Portuguese registries, led to the identification of >250 different mutations. It is a challenge determine pathogenic effect potential splice site mutations on VWF mRNA. This study aimed elucidate true effects 18 mRNA processing, investigate contribution next-generation sequencing vivo disease, compare findings with silico prediction. RNA extracted from patient platelets leukocytes was amplified by RT-PCR sequenced using...
BACKGROUNDSince it is currently not possible to eradicate hepatitis B virus (HBV) infection with existing treatments, research continues uncover new therapeutic strategies.HBV core protein, encoded by the HBV gene (HBC), intervenes in both structural and functional processes, a key protein life cycle.For this reason, could be valuable targets for diagnostic strategies.Moreover, alterations sequence serve as potential markers of disease progression.
Alpha-1 antitrypsin deficiency (AATD) is characterized by reduced serum levels of the AAT protein and predisposes to liver lung disease. The characterization at structural level novel pathogenic SERPINA1 mutants coding for circulating could provide insights into mechanisms misfolding. present study aimed a practical framework identification analysis new mutations, combining simulations clinical data.We analysed total five mutations (four not previously described) in six subjects presenting...
<b>Introduction:</b> AATD-associated lung disease is caused by a protease/antiprotease imbalance due to low circulating levels of alpha-1 antitrypsin (AAT) or decreased EIA. The aim this study was verify the reliability measurement EIA in patients with AATD and COPD. <b>Material methods:</b> Cross-sectional performed diagnosed COPD without Pi*ZZ. A control group healthy individuals included. AAT blood plasma were determined. Measurement conducted semiautomated immunoassay technique....
There is limited information about blood biomarkers in AATD. Therefore the aim of our study was to identify possible associations between serum and severity lung disease. Retrospective performed from database EARCO (European Alpha-1 Research Collaboration) International registry patients with AATD Pi*ZZ. Serum forced expiratory volume first second (FEV1) were collected. Neutrophil/lymphocyte ratio (NLR), eosinophil/lymphocyte (ELR) platelet/lymphocyte (PLR) calculated. Data analyzed...
<b>Introduction:</b> Currently there are no blood biomarkers to identify patients with PF secondary COVID-19 pneumonia. The ELF score is a panel of serum markers liver fibrosis; however, it has also been used in PF. We analyse the as biomarker due <b>Methods:</b> Pilot study performed random sample recovered from Chest computed tomography (CT) scan and lung function tests (LFTs) at 3 months after discharge were collected. Data analysed according scores posteriorly divided into tertiles:...