A5002211425- Pesticide and Herbicide Environmental Studies
- Genetically Modified Organisms Research
- Insect Resistance and Genetics
- Pesticide Exposure and Toxicity
- Weed Control and Herbicide Applications
- Insect and Pesticide Research
- Effects and risks of endocrine disrupting chemicals
- CRISPR and Genetic Engineering
- Environmental Justice and Health Disparities
- RNA modifications and cancer
- Folate and B Vitamins Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Congenital heart defects research
- Environmental Toxicology and Ecotoxicology
- Agricultural safety and regulations
- Gut microbiota and health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intellectual Property and Patents
- Toxic Organic Pollutants Impact
- Animal Genetics and Reproduction
- Entomopathogenic Microorganisms in Pest Control
- Carcinogens and Genotoxicity Assessment
École Polytechnique Fédérale de Lausanne
2018-2022
Université de Caen Normandie
2012-2017
Centre National de la Recherche Scientifique
2012-2014
The health effects of a Roundup-tolerant genetically modified maize (from 11% in the diet), cultivated with or without Roundup, and Roundup alone 0.1 ppb water), were studied 2 years rats. In females, all treated groups died 2-3 times more than controls, rapidly. This difference was visible 3 male fed GMOs. All results hormone sex dependent, pathological profiles comparable. Females developed large mammary tumors almost always often before pituitary second most disabled organ; hormonal...
The major pesticides of the world are glyphosate-based herbicides (GBH), and their toxicity is highly debated. To understand mode action, comparative herbicidal toxicological effects glyphosate (G) alone 14 its formulations were studied in this work, as a model for pesticides. GBH mixtures water, with commonly 36-48% G claimed active principle. As other pesticides, 10-20% consist chemical formulants. We previously identified these by mass spectrometry found them to be mainly families...
Pesticides are used throughout the world as mixtures called formulations. They contain adjuvants, which often kept confidential and inerts by manufacturing companies, plus a declared active principle, is usually tested alone. We toxicity of 9 pesticides, comparing principles their formulations, on three human cell lines (HepG2, HEK293, JEG3). Glyphosate, isoproturon, fluroxypyr, pirimicarb, imidacloprid, acetamiprid, tebuconazole, epoxiconazole, prochloraz constitute, respectively, 3 major...
The health effects of a Roundup-tolerant NK603 genetically modified (GM) maize (from 11% in the diet), cultivated with or without Roundup application and alone 0.1 ppb full pesticide containing glyphosate adjuvants) drinking water, were evaluated for 2 years rats. This study constitutes follow-up investigation 90-day feeding conducted by Monsanto order to obtain commercial release this GMO, employing same rat strain analyzing biochemical parameters on number animals per group as our...
Pesticide formulations contain declared active ingredients and co-formulants presented as inert confidential compounds. We tested the endocrine disruption of in six glyphosate-based herbicides (GBH), most used pesticides worldwide. All were comparably cytotoxic well below agricultural dilution 1% (18–2000 times for co-formulants, 8–141 formulations), not ingredient glyphosate (G) alone. The endocrine-disrupting effects all these compounds measured on aromatase activity, a key enzyme balance...
A broad community of independent scientific researchers and scholars challenges recent claims a consensus over the safety genetically modified organisms (GMOs). In following joint statement, claimed is shown to be an artificial construct that has been falsely perpetuated through diverse fora. Irrespective contradictory evidence in refereed literature, as documented below, claim there now on GMOs continues widely often uncritically aired. For decades, hotly controversial topic much debated...
A growing body of research suggests that dysbiosis the gut microbiota induced by environmental pollutants, such as pesticides, could have a role in development metabolic disorders. We examined long-term effects 3 doses Roundup(R) herbicide (made glyphosate and formulants) on male female Sprague-Dawley rats. total 141 bacteria families were identified 16S sequencing analysis approach. An OPLS-DA revealed an increased Bacteroidetes family S24-7 decreased Lactobacillaceae 8 out 9 females...
The quality of diets in rodent feeding trials is crucial. We describe the contamination with environmental pollutants 13 laboratory from 5 continents. Measurements were performed using accredited methodologies. All contaminated pesticides (1-6 out 262 measured), heavy metals (2-3 4, mostly lead and cadmium), PCDD/Fs (1-13 17) PCBs (5-15 18). Out 22 GMOs tested for, Roundup-tolerant most frequently detected, constituting up to 48% diet. main pesticide detected was Roundup, residues glyphosate...
Glyphosate has and is being used extensively in herbicide formulations worldwide. Thus, glyphosate-based herbicides (GBH) substantially add to the environmental load of pesticides warrant a strict risk assessment. Ecotoxicological testing focuses on non-target plants higher animals while direct effects arthropods are only cursory tested premise contact exposure. However, oral exposure, as we show our case, can be highly relevant for systemic pesticides, such GBH. Specifically, crop systems...
The insecticidal crystal proteins from Bacillus thuringiensis (Bt) are widely-used biopesticides that used both as Bt spore-crystal preparations in sprayable formulations and activated toxins genetically modified (GM) plants. Models for their modes of action have been proposed but many issues remain unresolved. Among those is the role commensal gut bacteria target insect death: previous studies showed antibiotics attenuate toxicity sprays. We tested whether interfere with effects GM...
Plant medicinal extracts may be claimed to prevent or cure chemical intoxications. Few of these are tested for their mechanisms actions in vivo and cellular impacts. In 2011, we demonstrated that hepatic cell mortality induced by environmentally realistic levels the widely used herbicide Roundup (R) vitro can almost entirely prevented plant called Dig1 (D, Digeodren). We effects D alone (1.2 ml/kg bw/d), but also prior during 8 days R intoxication (at 135 mg/kg bw/d) a total 4 groups 40...
Glyphosate has and is being used extensively in herbicide formulations worldwide. Thus, glyphosate-based herbicides (GBH) substantially add to the environmental load of pesticides warrant a strict risk assessment. Ecotoxicological testing focuses on non-target plants higher animals while direct effects arthropods are only cursory tested premise contact exposure. However, oral exposure, as we show our case, can be highly relevant for systemic pesticides, such GBH. Specifically, crop systems...