A5041394495- Calcium signaling and nucleotide metabolism
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Pneumonia and Respiratory Infections
- Lipid Membrane Structure and Behavior
- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- Neonatal and Maternal Infections
- Cellular transport and secretion
Biocant
2025
Universidade Nova de Lisboa
2019-2024
Group B Streptococcus (GBS) and Staphylococcus aureus cause 200.000 neonatal deaths every year no vaccine has been developed yet. Here, we described that extracellular glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from S. is an immunomodulatory protein. Antibody mediated neutralization of GAPDH promotes a protective inflammatory response by inhibiting early abnormal production IL-10 in infected mice. As role for was already GBS, selected peptides exposed on bacterial both bacteria but...
Breast cancer is the first cause of cancer-related mortality among women worldwide, according to most recent estimates. This mainly caused by tumors’ ability form metastases. Cancer cell migration and invasion are essential for metastasis rely on interplay between actin cytoskeleton remodeling adhesion. Therefore, understanding mechanisms which controlled may provide new strategies impair progression. We investigated role ADP-ribosylation factor (Arf)-like (Arl) protein Arl13b in breast...
Breast cancer (BC) is the most common type of in women, and remains one major causes death women worldwide. It now well established that alterations membrane trafficking are implicated BC progression. Indeed, pathways regulate cell proliferation, migration, invasion, metastasis. The 22 members ADP-ribosylation factor (ARF) >60 rat sarcoma (RAS)-related brain (RAB) families small GTP-binding proteins (GTPases), which belong to RAS superfamily, master regulators pathways. ARF-like (ARL)...
The prospect of drinking water serving as a conduit for gut bacteria, artificially selected by disinfection strategies and lack monitoring at the point use, is concerning. Certain opportunistic pathogens, notably some nontuberculous mycobacteria (NTM), often exceed coliform bacteria levels in water, posing safety risks. NTM other microbiota resist chlorination thrive plumbing systems. When inhaled, can infect lungs immunocompromised or chronically ill patients, elderly, primarily...