A5035163624- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Neuroendocrine regulation and behavior
- Telomeres, Telomerase, and Senescence
- Hormonal Regulation and Hypertension
- Eating Disorders and Behaviors
- Glioma Diagnosis and Treatment
- Sexual Differentiation and Disorders
- Gestational Diabetes Research and Management
- Electrolyte and hormonal disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Infant Health and Development
- Neuroendocrine Tumor Research Advances
- Menstrual Health and Disorders
- Head and Neck Surgical Oncology
- Thyroid Disorders and Treatments
- Pregnancy and preeclampsia studies
- Meningioma and schwannoma management
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Stress Responses and Cortisol
Universitat de Vic - Universitat Central de Catalunya
2021-2025
Centre for Biomedical Network Research on Rare Diseases
2015-2025
Hospital de Sant Pau
2013-2025
Centro de Investigación Biomédica en Red
2015-2025
Instituto de Salud Carlos III
2015-2025
Instituto de Investigación de Enfermedades Raras
2014-2025
Institut de Recerca Sant Pau
2024-2025
Massachusetts General Hospital
2018-2024
Harvard University
2018-2024
University Hospital Mútua de Terrassa
2024
Context:Pituitary adenomas and pheochromocytomas/paragangliomas (pheo/PGL) can occur in the same patient or family. Coexistence of two diseases could be due to either a common pathogenic mechanism coincidence.
The outcomes of transsphenoidal surgery (TSS) for pituitary adenoma (PA) depend on many factors, including the availability an expert team and volume surgeries performed. Data TSS PA are scarce in our country. TESSPAIN evaluates Spanish centers to assess influence surgical specialized neurosurgical teams success complication rates. A retrospective, nationwide, study performing between January 2018 December 2022. Centers were classified as high (HV) [n=11, defined with recognized expertise...
Abstract Oxytocin is a hypothalamic-posterior pituitary hormone with multiple effects, ranging from regulation of energy homeostasis to bone health and psychological wellbeing, in addition its well-known effects labor lactation. Patients hypothalamic damage have higher risk for medical psychiatric comorbidities despite standard-of-care replacement, clinically relevant oxytocin deficient state has been identified patients arginine vasopressin deficiency (formerly known as central diabetes...
Abstract Objective To improve our understanding of medical complications and endocrine alterations in patients with low‐weight avoidant/restrictive food intake disorder (ARFID) how they may differ from those anorexia nervosa (AN) healthy controls (HC). Method We performed an exploratory cross‐sectional study comparing females ARFID ( n = 20) AN 42) HC 49) no history eating disorder. Results found substantial overlap comorbidities features AN, but earlier onset aberrant behaviors ARFID. also...
Few data exist about the clinical course of acromegaly, surgical and medical outcomes in patients with GH- prolactin cosecreting pituitary adenomas (GH&PRL-PAs). Nevertheless, some series described a more aggressive clinic-radiological behavior than growth hormone-secreting (GH-PAs).
Accumulating preclinical and preliminary translational evidence shows that the hypothalamic peptide oxytocin reduces food intake, increases energy expenditure, promotes weight loss. It is currently unknown whether administration effective in treating human obesity.
Increasing evidence supports the presence of oxytocin deficiency (OXT-D) in hypopituitarism and hypothalamic damage (HHD). Identifying an applicable reliable test to diagnose OXT-D is unmet need. Melatonin might be a candidate for such as it regulates OXT release animals. To examine effects melatonin on HHD compared healthy controls (HC) describe psychopathology, sexual function quality life (QoL) their associations with OXT. This proof-of-concept study (NCT05319301) included 20 participants...
Introduction Cushing's syndrome (CS) increases cardiovascular risk (CVR) and adipocytokine imbalance, associated with an increased inflammatory state. Telomere length (TL) shortening is a novel CVR marker, inflammation biomarkers. We hypothesized that state higher in CS might be related to TL shortening, as observed premature aging. Aim To evaluate relationships between TL, markers CS. Methods In cross-sectional study, 77 patients (14 males, 59 pituitary-, 17 adrenal- 1 ectopic-origin; 21...
Context: Cushing’s syndrome (CS) is challenging to diagnose. Increased prevalence of CS in specific patient populations has been reported, but routine screening for remains questionable. To decrease the diagnostic delay and improve disease outcomes, simple new methods at-risk are needed. Objective: develop validate a scoring system predict based on clinical signs an easy-to-use biochemical test. Design: Observational, prospective, multicenter. Setting: Referral hospital. Patients: A cohort...
In diabetic pregnancy, neonatal hypoglycemia (NH) is usually attributed to insufficient regulation of maternal glycemic control. Recent data suggest that body mass index (BMI) could have an influence.Our objective was determine whether association exists between prepregnancy BMI category and occurrence NH among infants born women with gestational diabetes mellitus (GDM).This a retrospective study including all GDM pregnancies delivered 1986 2006 at tertiary care center (Hospital de la Santa...
Oxytocin (OT) and vasopressin share anatomical pathways of synthesis secretion, patients with central diabetes insipidus (CDI) presumably are at risk for OT deficiency. However, an OT-deficient state in hypopituitary has not been established. We hypothesized that men CDI compared to similar anterior pituitary deficiencies (APD) but no healthy controls (HC) age body mass index, would have lower plasma levels, associated increased psychopathology. Cross-sectional. Clinical research center....
Objective Affective alterations and poorer quality of life often persist in patients with Cushing’s syndrome (CS) remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic–pituitary–adrenal axis (HPA) is highly expressed brain areas controlling mood response to stress. Our aims were assess affective after long-term remission CS evaluate whether they are associated serum BDNF, salivary cortisol (SalF) and/or cortisone (SalE) concentrations. Subjects methods Thirty-six (32...
Abstract Context Medical treatment of acromegaly is currently performed through a trial-and-error approach using first-generation somatostatin receptor ligands (fgSRLs) as first-line drugs, with an effectiveness about 50%, and subsequent drugs are indicated clinical judgment. Some biomarkers can predict fgSRLs response. Objective Here we report the results ACROFAST study, trial in which protocol based on predictive was evaluated. Methods This prospective (21 university hospitals) comparing...
Abstract Background A clinically significant oxytocin-deficient state (OXT-D) has been established in adults with arginine vasopressin deficiency and there is a need to develop diagnostic testing. Kisspeptin (KP) candidate for such test as KP receptors are found on oxytocinergic neurons, administration increases plasma OXT animals. We hypothesized that intravenous would increase peripheral levels post-injection healthy adults. Methods KP-112-121 (KP analog, 0.24 nmol/kg bolus) was...
Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism (VTE).
Avoidant/restrictive food intake disorder (ARFID) is common among populations with nutrition-related medical conditions. Less known about the comorbidity/complication frequencies in youth ARFID. We evaluated comorbidities and metabolic/nutritional markers female male full/subthreshold ARFID across weight spectrum compared healthy controls (HC).
Patients with Cushing's syndrome (CS) in remission show sustained fatigue, myopathy, and an increased prevalence of sarcopenia. The mechanisms that determine these persistent muscle problems are not well known. We aimed to identify circulating microRNAs (miRNAs) differential expression could be potential biomarkers for the diagnosis and/or prognosis CS.
Pituitary apoplexy (PA) is the paradigm of endocrine and neurosurgical emergency.