A5086651433- Animal health and immunology
- Viral gastroenteritis research and epidemiology
- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- Gastrointestinal disorders and treatments
- DNA Repair Mechanisms
- Acute Lymphoblastic Leukemia research
- Cavitation Phenomena in Pumps
- Infant Nutrition and Health
- Polyomavirus and related diseases
- CRISPR and Genetic Engineering
- Effects of Environmental Stressors on Livestock
- Veterinary Equine Medical Research
- Platelet Disorders and Treatments
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Advanced biosensing and bioanalysis techniques
- Clostridium difficile and Clostridium perfringens research
- Cytokine Signaling Pathways and Interactions
- Carcinogens and Genotoxicity Assessment
- CAR-T cell therapy research
Stanford University
2021-2024
University of California, Davis
2015-2019
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for patients with many different blood and immune diseases; however, current regimens contain non-specific chemotherapy and/or irradiation conditioning, which carry both short-term long-term toxicities. The use of such agents may be particularly harmful Fanconi anemia (FA), who have genetic mutations resulting in deficiencies DNA repair, leading to increased sensitivity genotoxic agents. mAb-based conditioning has been...
Triplex gene editing relies on binding a stable peptide nucleic acid (PNA) sequence to chromosomal target, which alters the helical structure of DNA stimulate site-specific recombination with single-strand (ssDNA) donor template and elicits correction. Here, we assessed whether codelivery PNA encapsulated in Poly Lactic-co-Glycolic Acid (PLGA)-based nanoparticles can correct sickle cell disease x-linked severe combined immunodeficiency. However, through this process have identified...
Intravenous plasma administration has been recommended in healthy or sick calves with failure of passive immunity.IV administered plasma-derived immunoglobulin G (IgG) undergoes increased catabolism as reflected by a rapid decrease serum IgG concentration an increase fecal concentrations within 48 h.Thirty newborn Jersey calves. Fifteen were fed colostrum (CL group) and 15 given bovine IV (PL group).Randomized clinical trial. Calves the CL group 3 L once, oroesophageal tubing. PL at dosage...
Abstract Background Nonantibiotic alternatives providing local gut immunity have been recommended for managing calf diarrhea. Animals One hundred and two calves with Hypothesis Oral supplementation immunoglobulins in diarrhea will reduce time to resolution of diarrhea, number treatment events, mortality rate. Methods Randomized controlled trial. Calves were assigned into 1 3 groups. The group was supplemented 20 g milk twice daily 14 days. placebo a product similar nutritional value as the...
Abstract: Colostrum feeding provides immunoglobulins, in a process called transfer of passive immunity, which is critical for dairy calf health and welfare. However, failure immunity (FTPI) occurs about 12% calves nationwide. This study compares the prevalence FTPI between raised on organic conventional farms, describes colostral management practices farms California, recommends improvements. We compared serum immunoglobulin G (IgG) concentrations dairies found that odds were 2.5 times...
Abstract Background Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many diverse blood and immune diseases. However, HSCT regimens currently commonly utilize genotoxic chemotherapy and/or total body irradiation (TBI) conditioning which causes significant morbidity mortality through inducing broad tissue damage triggering infections, graft vs. host disease, infertility, secondary cancers. We previously demonstrated that targeted monoclonal antibody (mAb)-based HSC...
Abstract Objective To evaluate the suitability of infrared thermography in assessing healing surgically created wounds that are managed by primary closure or second intention neonatal dairy calves during a 3‐week period. Study design Randomized clinical trial. Animals Six Jersey bull calves. Methods Two skin patches approximately 10 cm 2 were shaved on each hind limb all The dorsal patch was designated wound creation site, and ventral control. sites randomly assigned for either intention....
Domestic and nondomestic ruminant neonates with failure of passive transfer immunity (FPI) have an increased risk morbidity mortality. Hand-reared individuals often a higher incidence FPI compared those that are dam-reared. Hand-reared, raised at zoological establishments fed commercially available bovine colostrum replacer. Consequently, it is desirable to monitor for using single test performs well across wide range species. The immunocrit method has been reported acceptable diagnostic...