A5073606716- Treatment of Major Depression
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- interferon and immune responses
- Congenital heart defects research
- Neurological disorders and treatments
- Bipolar Disorder and Treatment
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac electrophysiology and arrhythmias
- Mental Health Research Topics
- Coronary Artery Anomalies
- Perfectionism, Procrastination, Anxiety Studies
- Hormonal Regulation and Hypertension
Kansai Medical University
2015-2021
<b><i>Purpose:</i></b> The aim of this study was to compare the effects risperidone long-acting injection (RLAI) and paliperidone palmitate (PP) on non-acute-phase social functioning in patients with schizophrenia. <b><i>Patients Methods:</i></b> In 6-month pilot, open-label, randomized controlled study, 30 schizophrenia who had been treated RLAI were randomly allocated continuation group or switched PP group. Patients evaluated at baseline 6...
Individual differences in serotonin 1A (5-HT1A) receptor may result variable response to antipsychotics with 5-HT1A partial agonism. We investigated the relationship between gene (HTR1A) single nucleotide polymorphisms (SNPs) and efficacy of agonism Japanese patients schizophrenia. Perospirone or aripiprazole was administered 100 schizophrenia a randomized controlled study. Candidate SNPs were rs6295 (which affects HTR1A expression function), rs1364043, rs878567, rs10042486. Efficacy at week...
Recently, long-acting injection (LAI) of second-generation antipsychotics has become a valuable strategy for the treatment schizophrenia. However, few studies have compared effects different LAI on cognitive functions so far. The present study aimed to compare influence risperidone LAIs (RLAI) and paliperidone palmitate (PP) function in outpatients with In this 6-month, open-label, randomized, controlled study, 30 patients schizophrenia who were treated RLAIs randomly allocated...
<b><i>Background:</i></b> Individual differences in serotonin 7 receptor (5-HT7R) may result variable response to antipsychotics with 5-HT7R antagonism. This study investigated the relationship between single nucleotide polymorphisms (SNPs) gene (HTR7) and efficacy of second-generation antipsychotic drugs a high affinity for this Japanese schizophrenia. <b><i>Methods:</i></b> Perospirone or aripiprazole was administered 100 patients...
Abstract Background Differences in psychiatric background and dose–response to asenapine patients with schizophrenia were examined based on efficacy safety, using data obtained a double-blind, placebo-controlled trial. Methods Patients classified into three clusters by cluster analysis the Positive Negative Symptom Scale (PANSS) subscores at baseline, from 6-week, PANSS Marder factor scores calculated for each cluster. The of 10 or 20 mg/day score was used as primary endpoint, incidence...
Glycogen synthase kinase-3β (GSK-3β) polymorphisms are known to influence hippocampal brain tissue volume in individuals with major depressive disorder (MDD). However, the effects of GSK-3β gene single nucleotide (SNPs) those receiving antidepressant therapy unknown.In present study, we examined relationship between volume-related SNPs and treatment patients MDD.Paroxetine, fluvoxamine, or milnacipran was administered 143 Japanese MDD. Two (rs6438552 rs12630592) that hippocampus were...