A5040808622- Pain Mechanisms and Treatments
- Gastrointestinal motility and disorders
- Infant Health and Development
- Biochemical effects in animals
- Metabolism, Diabetes, and Cancer
- Ion Transport and Channel Regulation
- Myofascial pain diagnosis and treatment
- Gastroesophageal reflux and treatments
- Neuroendocrine regulation and behavior
- Acupuncture Treatment Research Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroscience of respiration and sleep
- Pediatric Pain Management Techniques
- Neuropeptides and Animal Physiology
- Exercise and Physiological Responses
Soochow University
2016-2022
Abstract Aims Painful diabetic neuropathy (PDN) is a refractory complication of diabetes. The study aimed to investigate the role α‐lipoic acid (ALA) on regulation transient receptor potential vanilloid‐1 (TRPV1) in dorsal root ganglion (DRG) neurons rats with Methods Whole‐cell patch‐clamp recordings were employed measure neuronal excitability DiI‐labeled DRG control and streptozotocin (STZ)‐induced rats. Western blotting immunofluorescence assays used determine expression location NF‐κBp65...
Summary Aims Insular cortex ( IC ) is involved in processing the information of pain. The aim this study was to investigate roles and mechanisms P2X7 receptors (P2X7Rs) development visceral hypersensitivity adult rats with neonatal maternal deprivation NMD ). Methods Visceral quantified by abdominal withdrawal reflex threshold colorectal distension CRD Expression P2X7Rs determined qPCR Western blot. Synaptic transmission recorded patch‐clamp recording. Results expression glutamatergic...
Abstract Chronic visceral pain is one of the primary symptoms patients with irritable bowel syndrome (IBS), which affects up to 15% population world-wide. The detailed mechanisms remain largely unclear. Our previous studies have shown that neonatal maternal deprivation (NMD) followed by adult multiple stress (AMS) advances occurrence pain, likely due enhanced norepinephrine (NE)-β 2 adrenergic signaling. This study was designed explore roles P2X3 receptors (P2X3Rs) in chronic induced...
Inflammatory pain is a severe clinical problem that affects the quality of life in patients. However, currently available treatments for inflammatory have limited effect and even causes side effects. The aim this study was to investigate roles miRNA-107 glutamate transporter 1 (GLT-1) rats induced by complete Freund's adjuvant (CFA).Paw withdrawal threshold (PWT) measured von Frey Filaments. expressions GLT-1 lumbar spinal dorsal horn (L4-L6) were with real-time quantitative PCR western...
Visceral hypersensitivity is a major clinic symptom in patients with irritable bowel syndrome (IBS). Anterior cingulate cortex (ACC) involved processing the information of pain. Both G protein-coupled receptor kinase 6 (GRK6) and P2Y purinoceptor (P2Y6) are associated neuroinflammation pathological The aim this study was to investigate interaction between GRK6 P2Y6 ACC development visceral adult offspring rats prenatal maternal stress (PMS).Visceral quantified by abdominal withdrawal reflex...
Abstract Aims Irritable bowel syndrome (IBS) is a common functional gastrointestinal disease characterized by abdominal pain. Our recent study has shown that the acid‐sensitive ion channel 1 (ASIC1) in dorsal root ganglion (DRG) involved stomachache of adult offspring rats subjected with prenatal maternal stress (PMS). MiR‐485 predicted to target expression ASIC1. The aim present was designed determine whether miR‐485/ASIC1 signaling participates enterodynia spinal horn PMS. Methods...