A5035571522- Reproductive Biology and Fertility
- 14-3-3 protein interactions
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Sperm and Testicular Function
- Lipid metabolism and biosynthesis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Prion Diseases and Protein Misfolding
- Mitochondrial Function and Pathology
- Childhood Cancer Survivors' Quality of Life
- Cell death mechanisms and regulation
- Pancreatitis Pathology and Treatment
- Food Science and Nutritional Studies
- GABA and Rice Research
- Birth, Development, and Health
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
St. Jude Children's Research Hospital
2013-2014
Duke University
2006-2009
The metabolism of the Xenopus laevis egg provides a cell survival signal. We found previously that increased carbon flux from glucose-6-phosphate (G6P) through pentose phosphate pathway in extracts maintains NADPH levels and calcium/calmodulin regulated protein kinase II (CaMKII) activity to phosphorylate caspase 2 suppress death pathways. Here we show addition G6P oocyte inhibits dephosphorylation/inactivation CaMKII bound by phosphatase 1. Thus, sustains phosphorylation at Ser-135,...
The metabolic status of a cell is fundamentally important factor in deciding whether or not engages its apoptotic machinery. We have previously shown that active metabolism regulates oocyte death via calcium/calmodulin-dependent protein kinase II (CaMKII) mediated phosphorylation caspase-2(1) but the link between activity and CaMKII poorly understood. In this study(2) we identify coenzyme A (CoA) as key signal inhibits Xenopus laevis apoptosis, novel mechanism activation. found CoA directly...