A5061233273- Simulation-Based Education in Healthcare
- Hearing, Cochlea, Tinnitus, Genetics
- Innovations in Medical Education
- Respiratory Support and Mechanisms
- Biomedical and Engineering Education
- Hearing Loss and Rehabilitation
- Genetics, Bioinformatics, and Biomedical Research
- Advances in Oncology and Radiotherapy
- Cardiac Arrest and Resuscitation
- Microbial Community Ecology and Physiology
- Ear Surgery and Otitis Media
- Identification and Quantification in Food
- Veterinary Practice and Education Studies
- Molecular Biology Techniques and Applications
- Health and Medical Research Impacts
- Metabolomics and Mass Spectrometry Studies
- Interprofessional Education and Collaboration
- Ion Channels and Receptors
- High Altitude and Hypoxia
- Health Sciences Research and Education
- Marine animal studies overview
- Patient Safety and Medication Errors
- Surgical Simulation and Training
- Neuroscience and Neural Engineering
- Educational Technology and Assessment
University of Bristol
1993-2018
Abstract Cell transplantation is a realistic potential therapy for replacement of auditory sensory neurons and could benefit patients with cochlear implants or acoustic neuropathies. The procedure involves many experimental variables, including the nature conditioning donor cells, surgical technique degree degeneration in host tissue. It essential to control these variables order develop cell techniques effectively. We have characterized conditionally immortal, mouse line suitable nerve....
Abstract Conditionally immortal cell lines were established from the ventral otocyst of Immortomouse at embryonic day 10.5 and selected to represent precursors auditory sensory neural epithelial cells. Selection was based upon dissection, tissue‐specific markers, expression transcription factor GATA3. Two expressed GATA3 but possessed intrinsically different genetic programs under differentiating conditions. US/VOT‐E36 represented progenitors with potential differentiate into nonsensory...
Abstract We have established a model for the in‐vitro differentiation of mouse cochlear hair cells and used it to explore influence retinoic acid on proliferation, cytoskeletal proteins voltage‐gated potassium conductances. The is based conditionally immortal cell line University Sheffield/ventral otocyst‐epithelial clone 36 (US/VOT‐E36), derived from ventral otic epithelial at embryonic day 10.5 transfected with reporter myosin VIIa. Retinoic did not increase proliferation but led...
We recorded K(+) currents in inner (IHCs) and outer (OHCs) hair cells from mice at embryonic days 16 18 on the day of birth (PO) to characterize their early physiological differentiation. In both cell types, outward increased size during late development, situated apical basal coils cochlea. Currents up six-fold, with current density increasing four-fold. were generally larger than apex, IHCs OHCs any given stage. OHCs, they initially non-inactivating but gained partial inactivation...
Intercalation in the biosciences is popular with medical undergraduates UK and mandatory at some institutions. It considered important that students develop skills an interest innovation research1 recognised as one way to enhance knowledge of research methodology.2 The intercalated year helps meet these aims by including project work part core course content. Projects are often practical laboratory-based, well other out-of-laboratory options such literature review or producing a grant...
Teaching with high-fidelity human simulators has traditionally been focussed on developing skills for the healthcare professions and we have previously shown that simulation can also be effectively used to teach basic biomedical sciences. 1 Here show engage school pupils during university visits inspire inform about potential future study careers related sciences health-care professions. We use in a number of different ways enhance our outreach programmes comprising laboratory presentations....