A5100784415- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Mycobacterium research and diagnosis
- Semiconductor Lasers and Optical Devices
- Oral microbiology and periodontitis research
- Plant-based Medicinal Research
- Fusion materials and technologies
- High-Temperature Coating Behaviors
- Liquid Crystal Research Advancements
- NF-κB Signaling Pathways
- Nuclear Materials and Properties
- Tuberculosis Research and Epidemiology
- Probiotics and Fermented Foods
- Immune Cell Function and Interaction
- Sphingolipid Metabolism and Signaling
- Advanced Optical Imaging Technologies
- Ginkgo biloba and Cashew Applications
- Endoplasmic Reticulum Stress and Disease
- Phytochemical Studies and Bioactivities
Southern Medical University
2018-2024
Tianjin University of Traditional Chinese Medicine
2014-2021
LMU Klinikum
2021
Ludwig-Maximilians-Universität München
2021
Fujian Medical University
2014-2017
The Sixth People's Hospital of Zhengzhou
2017
Mycobacterium tuberculosis, which primarily infects mononuclear phagocytes, remains the leading bacterial cause of enormous morbidity and mortality because infections in humans throughout world. The IL-1 family cytokines is critical for host resistance to M. tuberculosis As a newly discovered subgroup family, although IL-36 have been proven play roles protection against infection, antibacterial mechanisms are poorly understood. In this study, we demonstrated that IL-36γ conferred human...
Abstract Vitamin B6 is necessary to maintain normal metabolism and immune response, especially the anti‐inflammatory response. However, exact mechanism by which vitamin plays role still unclear. Here, we report a novel of preventing excessive inflammation via reduction in accumulation sphingosine‐1‐phosphate (S1P) S1P lyase (SPL)‐dependent manner macrophages. supplementation decreased expression pro‐inflammatory cytokines suppressing nuclear factor‐κB mitogen‐activated protein kinases...
Mycobacterium tuberculosis (Mtb) infection is a long-standing public health threat, and the development of host-directed therapy for eradicating Mtb requires better insights into Mtb-host interactions. Viperin [virus-inhibitory protein, endoplasmic reticulum–associated, interferon (IFN) inducible] an IFN-inducible protein with broad antiviral activities. Here, we demonstrated that was increased in abundance patients lymphatic pulmonary (TB). Viperin-deficient mice had decreased bacterial...
Ethnopharmacological Relevance. TZQ-F has been traditionally used in Traditional Chinese Medicine as a formula for the treatment of diabetes. Aim Study. This study aims to compare pharmacologic effects and gastrointestinal adverse events between acarbose. Methods. The double-blind randomized placebo-controlled fivefold crossover was performed 20 healthy male volunteers. Plasma glucose, plasma IRI, C-peptide were measured assess effects. Flatus bowel activity event effect. Results. 3 4...
Chronic inflammation is characterized by persisting leukocyte infiltration of the affected tissue, which enabled activated endothelial cells (ECs). inflammatory diseases remain a major pharmacotherapeutic challenge, and thus search for novel drugs drug targets an ongoing demand. We have identified natural product vioprolide A (vioA) to exert anti-inflammatory actions in vivo ECs vitro through inhibition its cellular target nucleolar protein 14 (NOP14). VioA attenuated microglia macrophages...
Absence of effective therapeutic methods for avascular necrosis femoral head (ANFH) is still perplexing the world's medical community. Bone marrow mesenchymal stem cells (BMSCs) adoptive cell therapy combined with core decompression a promising modality, which highly dependent on cellular activities BMSCs. Hepatocyte growth factor (HGF) survival BMSCs, yet underlying mechanism not fully elucidated. In this study, effects multiplicity infections (MOIs) recombinant adenovirus carrying HGF gene...
The effects of intravenous injection Porphyromonas gingivalis (Pg) on rabbit inflammatory immune response and atherosclerosis were evaluated by establishing a microamount Pg bacteremia model combined with high-fat diet. Twenty-four New Zealand rabbits randomly divided into Groups A-D<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mfenced...
A successful test of Ferroelectric Liquid Crystal Displays (FLCD) on Gen 4.5 is realized in this paper. new polyimide (PI) that can replace Nylon 6 (N6) synthesized and tested the production line. This used to be barrier commercialization FLCD. Apart from that, a FLC for mass synthesized. To investigate surface energy relative performance, various materials are compared. proof feasibility line significant step towards field‐sequential‐color high‐resolution FLCDs.
We achieve high‐framerate (< 100 μs) high‐contrast‐ratio ferroelectric liquid crystal displays (FLCD) on Gen 4.5. Innovatively, a new polyimide (PI) that is suitable for (FLC) alignment synthesized and tested the production line. It replaces Nylon 6 (N6), which was barrier to commercialization of FLCD. Moreover, FLC match requirements in mass production. Additionally, various materials were studied investigate surface energy relative performance. not only proof feasibility line, but also...
Mycobacterium tuberculosis, the pathogen that causes exhibits complex host-pathogen interactions. Pattern recognition receptors and their downstream signaling pathways play crucial roles in determining outcome of infection. In particular, scaffold protein β-arrestin 2 mediates G protein-coupled receptors. However, role conferring immunity against M. tuberculosis has not yet been explored. We found was upregulated lesioned regions lung tissues patients with tuberculosis. infection expression...