A5019728768- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Human Health and Disease
- Drug-Induced Hepatotoxicity and Protection
- Neurological Disorders and Treatments
- Trauma and Emergency Care Studies
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- Liver Disease Diagnosis and Treatment
- Healthcare Systems and Public Health
- Pelvic and Acetabular Injuries
- Muscle and Compartmental Disorders
- Pharmacological Effects of Natural Compounds
- Intramuscular injections and effects
- Wound Healing and Treatments
- Renal function and acid-base balance
- Neurogenesis and neuroplasticity mechanisms
- Apelin-related biomedical research
- Electrolyte and hormonal disorders
- S100 Proteins and Annexins
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ukraine: War, Education, Health
- Effects of Radiation Exposure
- Therapeutic Uses of Natural Elements
- Organ and Tissue Transplantation Research
I.Horbachevsky Ternopil National Medical University
1999-2024
Ministry of Health
2016-2021
Taras Shevchenko National University of Kyiv
2013
The aim: To determine the peculiarities of antioxidant-prooxidant balance in kidney rats different ages under conditions experimental cranioskeletal trauma (CST). Materials and methods: experiments involved 147 male white Wistar age groups. first group included immature animals aged 100-120 days. second sexually mature 6-8 months. third old 19-23 In all groups, CST was modelled thiopental-sodium anaesthesia. control groups only injected with were withdrawn from anaesthesia after 1, 3, 7, 14,...
The aim: to find out the effect of a two-hour tourniquets ischemia limb and acute blood loss on systemic disorders body in postperfusion period.Materials methods: experiments were performed 96 nonlinear male rats weighing 200-220 g. All under sodium thiopental anesthesia. In first experimental group, was simulated. second modeled. third these lesions combined. 1 2 hours, as well 1, 7 14 days, biliary function liver determined animals.Results: Two-hour reperfusion period compared with control...
Aim: The aim of the study was to determine impact cranioskeletal trauma (CST) on development endogenous intoxication syndrome in rats different ages.
Burns is the damage of skin or mucous membranes (often with underlying tissues), because high-temperature influence (thermal burns), chemical, electrical, radiation, combined, thermochemical and electrothermal factors influence. According to investigations, burns rank third among other injuries, in some countries, second, second only transport injuries. Although level survival after increasing, problem their treatment remains relevant modern medicine pharmacy. The aim was study peculiarities...
This study aimed to compare the differentiation and survival of human neural stem/progenitor cells various origins in vitro after transplantation into injured spinal cord laboratory animals. Rats with simulated injury were transplanted neurosphere obtained by directed HUES6 cell lines. Fluorescence microscopy was used visualize results. HUES6#1 iPSC#1 neurospheres showed a wide range markers associated glial differentiation. The expression proliferation marker Ki67 did not exceed 25%, both...
Acute generalized peritonitis (AGP) occurs in patients with concomitant pathology, particular at diabetes mellitus. The severity of depends on the adequacy immune response. Purpose research was to study features cellular arm response organism experimental animals simulated AGP setting mellitus (DM). 56 white rats were used experiment, which divided into three groups: main group – 24 AWP DM; comparison peritonitis. Animals modelled by injecting 10 % filtered fecal suspension abdominal cavity...
Мета роботи: зʼясувати вплив гострої крововтрати, ускладненої ішемією-реперфузією кінцівки, на діурез і швидкість клубочкової фільтрації та оцінити ефективність карбацетаму в корекції виявлених порушень.
 Матеріали методи. Експерименти виконано 96 нелінійних щурах-самцях масою 160–180 г. Усіх тварин поділили пʼять груп: контрольну чотири дослідних (по 6 щурів у групі). До першої дослідної групи увійшли тварини, яким під тіопентал-натрієвим наркозом моделювали двогодинну ішемію кінцівки...
Introduction. Traumatic events are considered to be one of the current problems in modern urban society. Beyond being immediate cause death injured, development multiple organ failure syndrome is a perilous complication severe and combined trauma. An experimental cranioskeletal trauma known accompanied by internal dysfunction. Nonetheless, dysfunction terms hypoxia resistance presence remains insufficiently studied.The objective research: establish dynamics functional state liver trauma,...
Aim. To determine the peculiarities of enzymatic and glutathione link antioxidant protection liver rats different age in case experimental cranioskeletal injury. Materials methods. Cranioskeletal trauma (CST) was modelled three groups (sexually immature, sexually mature, old) under thiopental sodium anesthesia. Rats were removed from experiment anesthesia after 3 7 days post-traumatic period. Superoxide dismutase catalase activity, as well peroxidase (GP) reductase (GR) activity content...
Мета роботи: з’ясувати динаміку супероксиддисмутазної (СОД-) та каталазної активності печінки щурів різного віку за умов експериментальної краніоскелетної травми. Матеріали і методи. У трьох вікових груп (статевонезрілі, статевозрілі, старі) в умовах тіопенталонатрієвого наркозу моделювали краніоскелетну травму (КСТ). Щурів виводили з експерименту через 1, 3, 7, 14, 21 28 діб посттравматичного періоду. В екстракті гомогенату визначали СОД- каталазну активність. Результати. Встановлено, що,...
Aim: To determine the effect of cell therapy on intensity lipid peroxidation processes in liver, kidneys and lungs rats different ages under conditions experimental cranio-skeletal trauma (CST). Materials Methods: In experiments, 129 white male Wistar line age groups were used: immature aged 100-120 days weighing 90-110 g; mature 6-8 months 180-200 old 19-23 300-320 g. each group, CST was modeled thiopental sodium anesthesia. The control only injected with For purpose correction,...
В сучасних умовах значно зросла частота травм із масивною зовнішньою кровотечею, які вимагають негайного накладання артеріального джгута на кінцівку з безпечним терміном до 2-х год. окремих роботах показана можливість розвитку ускладнень як під джгутом, так і внаслідок реперфузії кінцівки. Однак її влив антиоксидантно-прооксидантний баланс внутрішніх органів вивчений недостатньо.Мета дослідження. З’ясування впливу двогодинного застосування кінцівки динаміку антиоксидантно-прооксидантних...
Introduction. Activation of lipid peroxidation processes, which are exacerbated in cases limb ischemia-reperfusion associated with temporary application a tourniquetis key mechanism acute blood loss. However, its significance the pathogenesis renal dysfunction is understudied. The information on effectiveness carbacetam administration under these conditions, has an antioxidant effect, lacking.Objective. aim research was to investigate processes excretory loss complicated by...
Вступ. Накопичення окиснених білків розглядають як один із факторів регуляції синтезу і розпаду білків, активації мультикаталітичних протеаз, які вибірково руйнують окиснені білки. Відомо, що цукровий діабет супроводжується порушенням усіх видів обміну речовин, тому доцільним було вивчення особливостей однієї з патогенетичних ланок гострого поширеного перитоніту, який виник на тлі цукрового діабету, – окиснювальної модифікації білків.
 Мета дослідження вивчити та оцінити стан в...
Introduction. Under conditions of massive bleeding from the extremities, both in combat and peacetime, only means for salvation is applying tourniquet, which completely stops arterial blood flow. It believed that maximum safe time limb due to use tourniquet up two hours. The systemic effect acute loss complicated by ischemia-reperfusion on liver, main organ detoxification body, remains almost unexplored.Objective research: determine two-hour ischemia its reperfusion absorption-excretory...
<p>In the conditions of cranial-skeletal trauma throughout period late signs traumatic disease (14–28 days),<br />the processes lipidic peroxidation don’t calm down, activity antioxidant protection ferments remains reduced,<br pro-oxidant mechanisms dominate. The use thiocetam in 250 mg/kg dosage intraperatoneal 14<br />days after striking essentially lowers manifestations free radical oxidation the<br />lipids, superoxide dismutase and catalase increases,...
Introduction: The kidneys remain one of target organs in acute blood loss various genesis. Reduced perfusion leads to an increase renal insufficiency, primarily characterized by decreased urine production and glomerular filtration rate. Timely restoration lost volume deficit stands as a critical objective addressing hypovolemic shock. Among the first-line therapeutic approaches, administration balanced crystalloids 1:1 ratio relative has demonstrated efficacy; combined use antioxidants is...
Background. Associated injury is a worldwide social and economic problem. Age related aspects of endogenous intoxication are not studied comprehensively. Annually, from 44 000 to 65 citizens die because traumatic injuries. As result, this number increased by 32.6% for the last 10 years. The detoxification system, as component functional systems organism, experiences significant changes in case polytrauma.Objective. study was aimed discover pathogenetic peculiarities multiple trauma age...