A5031227122- Bat Biology and Ecology Studies
- Viral Infections and Vectors
- interferon and immune responses
- Marine Bivalve and Aquaculture Studies
- Genomics and Phylogenetic Studies
- Marine Biology and Environmental Chemistry
- Genetics, Aging, and Longevity in Model Organisms
- Circular RNAs in diseases
- Physiological and biochemical adaptations
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Molecular Biology Techniques and Applications
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- RNA modifications and cancer
- Aquaculture Nutrition and Growth
- Genetic Mapping and Diversity in Plants and Animals
- Calcium Carbonate Crystallization and Inhibition
- Cancer-related molecular mechanisms research
- Reproductive biology and impacts on aquatic species
- Maritime Transport Emissions and Efficiency
- Hepatitis C virus research
- MXene and MAX Phase Materials
- Lymphatic System and Diseases
University College Dublin
2016-2025
Guangzhou University of Chinese Medicine
2025
University of South China
2022
Xiamen University
2012-2019
Abstract Bats possess extraordinary adaptations, including flight, echolocation, extreme longevity and unique immunity. High-quality genomes are crucial for understanding the molecular basis evolution of these traits. Here we incorporated long-read sequencing state-of-the-art scaffolding protocols 1 to generate, our knowledge, first reference-quality six bat species ( Rhinolophus ferrumequinum , Rousettus aegyptiacus Phyllostomus discolor Myotis myotis Pipistrellus kuhlii Molossus molossus...
Zoonoses are infectious diseases transmitted from animals to humans. Bats have been suggested harbour more zoonotic viruses than any other mammalian order1. Infections in bats largely asymptomatic2,3, indicating limited tissue-damaging inflammation and immunopathology. To investigate the genomic basis of disease resistance, Bat1K project generated reference-quality genomes ten bat species, including potential viral reservoirs. Here we describe a systematic analysis covering 115 that revealed...
Understanding aging is a grand challenge in biology. Exceptionally long-lived animals have mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats on chromosome tips shorten with cell division, potentially limiting life span. Bats the longest-lived mammals for their size, but it unknown whether telomeres shorten. Using >60 years of cumulative mark-recapture field data, we show age Rhinolophus ferrumequinum and Miniopterus schreibersii, not bat genus greatest...
Abstract Comprising more than 1,400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity, and extraordinary immunity. Some of the molecular mechanisms underlying these includes DNA repair, metabolism However, analyses have been limited to a few divergent lineages, reducing scope inferences on gene family evolution across Order Chiroptera. We conducted an exhaustive comparative genomic study 37 bat one generated in this study, encompassing...
Research on the mechanism for early development of shellfish, such as body plan, shell formation, settlement and metamorphosis is currently an active research field. However, studies were still limited not deep enough because lack genomic resources genome or transcriptome sequences. In present research, de novo sequencing was performed Crassostrea angulata, most economically important cultured oyster species in China, at eight developmental stages using 454 technology. A total 555,215 reads...
Chiroptera, the bats, are only order of mammals capable true self-powered flight. Bats exhibit a number other exceptional traits such as echolocation, viral tolerance and, perhaps most puzzlingly, extreme longevity given their body size. Little is known about molecular mechanisms driving extended particularly at levels gene expression and post-transcriptional regulation. To elucidate that may underlie unusual longevity, we have deep sequenced 246.5 million small RNA reads from whole blood...
AbstractEthnopharmacological relevance: Osteosarcoma (OS) is a malignant bone tumor that predominantly occurs in adolescents, and there an urgent need to identify effective therapeutic drugs. Xihuang Pill (XHP) traditional Chinese medicine formulation has been shown exhibit significant inhibitory effects on various tumors, including sarcoma. However, the specific mechanisms underlying action of XHP treatment osteosarcoma remain be further elucidated.Aim study: The aim this study investigate...
<title>Abstract</title> <bold>Background</bold>: Isorhapontigenin is an effective active ingredient in rheum officinale, which has been reported to have anti-tumor effects. However, its effect and molecular mechanism on non-small cell lung cancer are still unclear. <bold>Methods</bold>: Firstly, potential therapeutic targets of against were obtained through network pharmacology analysis. Secondly, bioinformatics analysis was conducted identify key signaling pathway mechanisms based the...
Background Cephalopoda are a class of Mollusca species found in all the world's oceans. They an important model organism neurobiology. Unfortunately, lack neuronal molecular sequences, such as ESTs, transcriptomic or genomic information, has limited development neurobiology research this unique organism. Results With high-throughput Illumina Solexa sequencing technology, we have generated 59,859 high quality sequences from 12,918,391 paired-end reads. Using BLASTx/BLASTn, 12,227 contigs...
The three prime untranslated region (3′-UTR) is known to play a pivotal role in modulating gene expression by determining the fate of mRNA. Many crucial developmental events, such as mammalian spermatogenesis, tissue patterning, sex determination and neurogenesis, rely heavily on post-transcriptional regulation 3′-UTR. However, 3′-UTR biology seems be relatively untapped field, with only limited tools resources available. To elucidate regulatory mechanisms expression, firstly sequences must...
The acquisition of tissue samples from wild populations is a constant challenge in conservation biology, especially for endangered species and protected where nonlethal sampling the only option. Whole blood has been suggested as sample type that contains high percentage bodywide genomewide transcripts therefore can be used to assess transcriptional status an individual, infer genome. However, limited quantities nonlethally sampled small it not known if enough genetic material contained few...
Abstract Bats carry viruses that can cause severe disease in other mammals. Asymptomatic infections bats suggest limited tissue-damaging inflammation and immunopathology. To investigate the genomic basis of resistance, Bat1K project generated reference-quality genomes ten bat species. A systematic analysis showed signatures selection immune genes are more prevalent compared with We found an excess gene adaptations ancestral Chiroptera many descending lineages, highlighting viral entry...
Crassostrea angulata, a major shellfish cultivated in Southern China, has experienced notable surge commercial value recent years. Understanding the molecular mechanisms governing their reproductive processes holds significant implications for advancing aquaculture practices. In this study, we cloned orphan nuclear receptor gene, Fushi Tarazu transcription factor 1 (FTZ-F1), of C. angulata and investigated its functional role gonadal development. The full-length cDNA FTZ-F1 spans 2357 bp...
Background The abalone Haliotis diversicolor is a good model for study of the settlement and metamorphosis, which are widespread marine ecological phenomena. However, information on global gene backgrounds expression profiles early development abalones lacking. Methodology/Principal Findings In this study, eight non-normalized multiplex barcode-labeled transcriptomes were sequenced using 454 GS system to cover developmental stages H. diversicolor. assembly generated 35,415 unigenes, 7,566...
Autophagy maintains cellular homeostasis and its dysfunction has been implicated in aging. Bats are the longest-lived mammals for their size, but molecular mechanisms underlying extended healthspan not well understood. Here, drawing on >8 years of mark-recapture field studies, we report first longitudinal analysis autophagy regulation bats. Mining published population level aging blood transcriptomes (
Abstract Bats account for ~20% of all extant mammal species and are considered exceptional given their extraordinary adaptations, including biosonar, true flight, extreme longevity, unparalleled immune systems. To understand these we generated reference-quality genomes six representing the key divergent lineages. We assembled with a novel pipeline incorporating state-of-the-art long-read long-range sequencing assembly techniques. The were annotated using maximal evidence approach, de novo...
Bats are the longest-lived mammals given their body size with majority of species exhibiting exceptional longevity. However, there some short-lived that do not exhibit extended lifespans. Here we conducted a comparative genomic and transcriptomic study on long-lived Myotis myotis (maximum lifespan = 37.1 years) Molossus molossus 5.6 to ascertain genetic difference underlying divergent longevities. Genome-wide selection tests 12,467 single-copy genes between M. revealed only three (CCDC175,...
The escape of DNA from mitochondria into the nuclear genome (nuclear mitochondrial DNA, NUMT) is an ongoing process. Although pervasively observed in eukaryotic genomes, their evolutionary trajectories a mammal-wide context are poorly understood. main challenge lies orthology assignment NUMTs across species due to fast evolution and chromosomal rearrangements over past 200 million years. To address this issue, we systematically investigated characteristics NUMT insertions 45 mammalian...
<title>Abstract</title> The carnivorous marine gastropod, <italic>Rapana venosa</italic>, also known as the veined rapa whelk, has recently gained considerable attention due to its dual significance both a valuable commercial seafood resource and biological invader with widespread ecological implications. Significant efforts have been made investigate molecular pathways governing specific adaptations in <italic>R. venosa</italic>. However, regulatory mechanisms of these remain largely...
Natural selection has shaped a wide range of lifespans across mammals, with few long-lived species showing negligible signs ageing. Approaches used to elucidate the genetic mechanisms underlying mammalian longevity usually involve phylogenetic tests on candidate genes, detections convergent amino acid changes in lineages, analyses differential gene expression between age cohorts or species, and measurements age-related epigenetic changes. However, link duplication evolution not been widely...
The Fujian oyster, Crassostrea angulata, accounts for approximately 50% of the total oyster production in China and is one most economically important marine products. In this study, we investigated differential gene expression profiles between diploid (n = 2) triploid 3) oysters that may indicate specific adaptation associated with ploidy. A 14,626,126 15,492,551 reads were generated from muscle transcriptomes using Illumina RNA-Seq respectively. Gene analysis revealed a 2,045...
Aging is an independent risk factor for heart failure (HF), and endothelial progenitor cell (EPC) function decreases with aging. Here, we further investigated whether age has a detrimental effect on circulating EPC in HF mildly reduced ejection fraction (HFmrEF) its relationship systemic inflammation. 58 HFmrEF patients were recruited. The adhesive, migrative, proliferative activities of EPCs, MAGGIC scores, plasma interleukin (IL)-17 IL-23 levels these assessed. Older had higher scores...