High-intensity focused ultrasound (HIFU) therapy can be used for noninvasive treatment of kidney (renal) cancer, but the clinical outcomes have been variable. In this study, efficacy renal HIFU was studied using nonlinear acoustic and thermal simulations in three patients.The were conducted with without refraction order to investigate its effect on shape, size, pressure distribution at focus. The values attenuation, sound speed, perfusion, conductivity varied over reported ranges determine...

The study aim was to utilise multiple feature selection methods in order select the most important parameters from clinical patient data for high-intensity focused ultrasound (HIFU) treatment outcome classification uterine fibroids. retrospective using 66 HIFU treatments with 89 A total of 39 features were extracted and 14 different filter-based used informative features. selected then a support vector (SVC) model evaluate performance these predicting therapy outcome. defined as non-perfused...

Background: MRI-guided transurethral ultrasound ablation (TULSA) has been evaluated for organ-confined prostate cancer (PCa). The purpose of this study was to assess the safety and toxicity, accuracy short-term evolution cell-death after lesion-targeted TULSA.Methods: This prospective, registered, Phase-I treat-and-3-week-resect-study enrolled six patients with MRI-visible-biopsy-concordant PCa. Lesions were targeted using TULSA radical intent, except near neurovascular bundles (NVB)....

Up to half of all men who undergo primary radiotherapy for localized prostate cancer (PCa) experience local recurrence.To evaluate the safety and early functional oncological outcomes salvage magnetic resonance imaging-guided transurethral ultrasound ablation (sTULSA) with radiorecurrent PCa.This prospective, single-center phase 1 study (NCT03350529) enrolled biopsy-proven PCa recurrence after radiotherapy. Multiparametric imaging (mpMRI) 18F prostate-specific membrane antigen-1007 (18F...

Multiple ultrasound elastography techniques rely on acoustic radiation force (ARF) in monitoring high-intensity focused (HIFU) therapy. However, ARF is dependent tissue attenuation and sound speed, both of which are also known to change with temperature making the therapy more challenging. Furthermore, viscoelastic properties dependent, affects displacements induced by ARF. The aim this study quantify changes liver investigate their effect using experimental methods simulations....

Objective: High-intensity focused ultrasound (HIFU) therapy can be used for noninvasive treatment of kidney (renal) cancer, but the clinical outcomes have been variable. In this study, efficacy renal HIFU was studied using a nonlinear acoustic and thermal simulations in three patients. Methods: The were conducted with without refraction order to investigate its effect on shape, size, pressure distribution at focus. values attenuation, sound speed, perfusion, conductivity varied over reported...

Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and deep location kidney cause significant losses to efficiency treatment. The effect attenuation, refraction reflection due different types on HIFU therapy was studied nonlinear simulation model. geometry derived from computed tomography (CT) dataset patient had been segmented for water, bone, soft tissue, fat kidney....

Introduction Uterine fibroids are the most common benign neoplasms in women. The administration of intravenous oxytocin is known to increase efficacy a non-invasive thermal ablation method (MR-HIFU) for treating fibroids. However, it not whether this phenomenon caused by effect on myometrium or fibroid itself. objective study was evaluate influence blood flow fibroids, and skeletal muscle using quantitative perfusion MRI technique.Materials methods 17 premenopausal women with considered be...

Locally advanced prostate cancer can cause bladder outlet obstruction, gross hematuria and frequent hospitalization. While these complications are commonly treated by palliative transurethral resection of the prostate, improvement is often insufficient. The purpose this study was to evaluate safety feasibility MRI-guided ultrasound ablation as an alternative treatment option (pTULSA) for men suffering from symptomatic locally cancer.This prospective, phase one included 10 in need surgical...

Transurethral ultrasound therapy is an investigational treatment modality which could potentially be used for the localized of prostate cancer. One limiting factors this prostatic calcifications. These attenuate and reflect thus reduce efficacy heating. The aim study to investigate how calcifications affect therapeutic efficacy, identify best sonication strategy when are present.Realistic computational models were on clinical patient data in order simulate different situations with naturally...

Abstract Triggered release and targeted drug delivery of potent anti-cancer agents using hyperthermia-mediated focused-ultrasound (FUS) is gaining momentum in the clinical setting. In early phase studies, tissue biopsy samples may be harvested to assess efficacy demonstrate lack instantaneous cell death due FUS exposure. We present an optimised recovery method a viability assay, compatible with intra-cellular doxorubicin. Flow cytometry was used determine levels suspensions comprised of: (i)...

Magnetic resonance guided high-intensity focused ultrasound (MR-HIFU) therapy is not feasible in all patients with uterine fibroids because of limiting anatomical factors such as scar tissue, bowel loops or other obstacles the sonication path. These may prevent treatment limit window, and therefore, also volume where HIFU can be delivered. Bowel present a particular problem gas bubbles hard particles which cause reflection absorption energy, potentially leading to thermal damage even...

Purpose: Prostate cancer can be eradicated with heat exposure. However, high and rapid temperature elevations may cause thermofixation giving the appearance of viable tissue. The purpose was to characterize immunoprofile evaluate viability prostate regions suspected thermofixation.Methods materials: A prospective, ethics-approved registered study (NCT03350529) enrolled six patients MRI-visible, biopsy-concordant undergo lesion-targeted MRI-guided transurethral ultrasound ablation (TULSA)...

Magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) is an emerging method for treatment of localized prostate cancer (PCa). TULSA-related subacute MRI findings have not been previously characterized.To evaluate acute and after TULSA in a treat-and-resect setting.Six men with newly diagnosed MRI-visible biopsy-concordant clinically significant PCa were enrolled completed the study. Eight lesions classified as PI-RADS 3-5 focally ablated using TULSA. One-...

A clinical case study of high-intensity focused ultrasound (HIFU) treatment in the uterine fibroid was conducted. During therapy, poor heating efficacy observed which could be attributed to several factors such as local perfusion rate, patient-specific anatomy or changes acoustic parameters field. In order determine cause diminished heating, analyses and simulations were conducted using magnetic resonance imaging (MRI) data from treatment. The analysis showed high rate myoma (301.0 +- 25.6...

Therapeutic ultrasound is an investigational modality which could potentially be used for minimally invasive treatment of prostate cancer. Computational simulations were to study the effect natural physiological variations in tissue parameters on efficacy therapeutic prostate. The conducted a clinical therapy system using patient computed tomography (CT) data. values attenuation, perfusion, specific heat capacity and thermal conductivity changed within their biological ranges determine peak...