A5049163452- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Genomics and Chromatin Dynamics
- Machine Learning in Bioinformatics
- Metabolism and Genetic Disorders
- Advanced Multi-Objective Optimization Algorithms
- Nuclear Structure and Function
- Epilepsy research and treatment
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Neurological disorders and treatments
- Topology Optimization in Engineering
- Neuroscience and Neuropharmacology Research
- Synthesis and biological activity
- Cytokine Signaling Pathways and Interactions
- Composite Material Mechanics
- RNA Research and Splicing
- Synthesis and Reactivity of Heterocycles
- Amino Acid Enzymes and Metabolism
- Botulinum Toxin and Related Neurological Disorders
- Mass Spectrometry Techniques and Applications
- Synthesis and Reactions of Organic Compounds
- Analytical Chemistry and Chromatography
- Hereditary Neurological Disorders
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
Riga Technical University
2023
Latvijas Organiskās Sintēzes Institūts
2001-2018
Institute of Organic Synthesis
2001-2008
MerLion Pharma (Germany)
2006
Uppsala University
2001-2002
Botulinum neurotoxins (BoNTs) cause muscle paralysis by selectively cleaving core components of the vesicular fusion machinery within motoneurons. Complex gangliosides initially bind into a pocket that is conserved among seven BoNTs and tetanus neurotoxin. Productive neurotoxin uptake also requires protein receptors. The interaction site receptor currently unknown. We report identification characterization binding BoNT/B BoNT/G. Their receptors, synaptotagmins I II, to at tip their H(CC)...
Abstract We have developed an alignment‐independent method for classification of G‐protein coupled receptors (GPCRs) according to the principal chemical properties their amino acid sequences. The relies on a multivariate approach where primary sequences are translated into vectors based physicochemical acids and transformation data uniform matrix by applying modified autocross‐covariance transform. application component analysis set 929 class A GPCRs showed clear separation major classes...
A discriminating pharmacophore model for noncompetitive metabotropic glutamate receptor antagonists of subtype 1 (mGluR1) was developed that facilitated the discovery moderately active mGluR1 antagonists. One scaffold selected design several focused libraries where different substitution patterns were introduced. This approach potent antagonists, as well positive and negative mGluR5 modulators, because both subtypes share similar binding pockets. For a homology mGlu1 established, putative...
Abstract This article reviews recent advances towards an understanding of the transmembrane structure, its activation and binding sites family 3 G‐Protein‐Coupled Receptors (3‐GPCRs). First, prediction their 3D structure via homology models based on crystal bovine rhodopsin will be discussed. Then, different kinetic mechanisms ligand‐binding inside heptahelical domain are presented before overview most common structural motifs 3‐GPCR allosteric modulators given. Here, special focus lies in...
Background: B-cell Lymphoma Extra Large (Bcl-XL) belongs to two (Bcl-2) family. Due its over-expression and anti-apoptotic role in many cancers, it has been proven be a more biologically relevant therapeutic target anti-cancer therapy. In this study, Quantitative Structure Activity Relationship (QSAR) modeling was performed establish the link between structural properties inhibitory potency of benzothiazole hydrazone derivatives against Bcl-XL. Methods: The 53 have used for model development...
Abstract 3D printed plastic casts can be used for healing bone fractures. The main requirements these cases are: they should light, require little printing time, have good mechanical properties, and ensure proper skin ventilation. We present a density-based topology optimization algorithm obtaining optimal cast shapes that fulfil requirements. uses linear stress model simplified boundary conditions to the contact problems. were optimized against influence of several sharp corners. parametric...