Capsicum annuum L. fruits, renowned for their nutritional and medicinal value, were explored as a source of valuable compounds. A method involving saponification, extraction, column chromatography was utilized to isolate two significant compounds, β-sitosterol β-citraurin, from paprika oleoresin. These known distinct properties, identified through nuclear magnetic resonance, mass spectrometry, chromatographic techniques. The newly developed proved be efficient, with reduced elution times,...

Ojamin (OJ), a polyherbal antidiabetic formulation, is extensively used as food supplement to control diabetes alone or along with synthetic agents. However, it's phytochemical and pharmacological investigations are lacking.The present study was undertaken antihyperlipidemic potentials of OJ its interaction Metformin in streptozotocin (STZ)-induced diabetic rats.Diabetes induced Wistar rats by single intraperitoneal (i.p.) injection (60 mg/kg). Antidiabetic, activities were evaluated at dose...

Two methods for the simultaneous determination of Emtricitabine and Tenofovir by spectroscopy have been developed.These two simple, accurate precise include Area Under Curve (AUC) method Dual Wavelength Method.From a solvent effect studies spectral behaviours Tenofovir, methanol was selected as solvent.Emtricitabine shows maximum absorbance at 281 nm 259 nm.For AUC method, wavelength ranges between 242-248 269-275 were with reference to curves plotted wavelengths 200-400 nm.In second...

Three simple, economical, precise, and accurate methods are described for the simultaneous determination of Tenofovir disoproxil fumarate (TE) Emtricitabine (EM) in combined tablet dosage form. The first method is ratio derivative spectra, second first-order spectrophotometry third absorption corrected method. amplitudes at 271.07 302.17 nm method, 224.38 306.88 order were selected to determine (EM), respectively, formulation. Beer's law obeyed concentration range 3-21 μg/ml TE 2-14 EM two...

In the present study, Zinc oxide nanoparticles andSilver Oxide were evaluated for their in vivo and vitro antidiabetic activity. The resulting ZnO, Ag2O characterized via various methods like UV, XRD, FTIR, PSA SEM, TEM, ICP-OES. synthesized NPs tested sub-acute oral toxicity model by abiding OECD425 guidelines. male Wistar rats with a weight ranging from 180-200 g grouped as follows: normal control: those that didn’t received any trea

A simple, rapid and precise reversed-phase liquid chromatographic method is developed for simultaneous determination of Atorvastatin, Ezetimibe Fenofibrate in their ternary mixture commercial pharmaceutical preparations.This method, reported first time a mixture, uses Kromasil C18, 250 × 4.6 mm, 5µm analytical column.Analytes were estimated by gradient elution with methanol/water at flow rate 0.9 mL/min; the column temperature 40°C detector wavelength 240 nm.The sample concentrations are...

To develop a simple, precise, rapid and accurate HPTLC method for the simultaneous estimation of Lornoxicam (LOR) Thiocolchicoside (THIO) in bulk pharmaceutical dosage forms.The separation active compounds from form was carried out using methanol:chloroform:water (9.6:0.2:0.2 v/v/v) as mobile phase no immiscibility issues were found. The densitometric scanning at 377 nm. validated linearity, accuracy, precision, LOD (Limit Detection), LOQ Quantification), robustness specificity.The Rf values...

The study was undertaken to evaluate single herb formulation (SHF) as Saptarangi tablet (ST) and polyherbal formulations (PHF) plus Kadha (SK) for diabetes hyperlipidemia. main objective of proposed the anti-diabetic anti-hyperlipidemic activities ST SK in streptozotocin (STZ)-induced diabetic rats, well their interactions with metformin (MET), order prove complementary alternative medicine (CAM) treatments. intraperitoneal injection (i.p.) STZ at dose 45mg/kg given induce Wistar albino...

A simple, economical, precise, and accurate new UV-visible spectrophotometric baseline manipulation method for simultaneous determination of tenofovir disoproxil fumarate (TE) emtricitabine (EM) in combined tablet dosage form has been developed. The is based on (difference) spectroscopy where amplitudes at 261 289.9 nm were selected to determine TE EM, respectively, formulation, distilled water was used as solvent. Both drugs obey Beer’s law the concentration ranges 4–20 μ g/mL 6–30 EM....

Non organic food and chemical intake has been associated with a variety of infections disorders, notably cancer, digestive dysfunction, headaches, ADHD (Attention Deficit Hyperactivity Disorder), prenatal deformities, compromised immune system early mortality. Organic foods are pesticide-free it is beneficial for overall health. farming initiated 1000 years ago, once mediaeval farmers began cultivating along riverbeds based on natural resources. products the finest healthy which can be...

A simple, precise bioanalytical UPLC Tandem Mass Spectroscopy gradient elution method was developed and validated for simultaneous estimation of Olmesartan Medoximil (OLM) Metoprolol Succinate (MET) in human plasma. The quantitation carried out using Shimadzu Shimpack-C18 GIST AQ (50 mm X 2.1 mm, 1.9 µm) column the mobile phase comprises 0.1% formic acid B as acetonitrile used elution. Analysis completed within run time 4 min at flow rate 0.3mL/min. retention metoprolol succinate olmesartan...

A simple, economical, precise, and accurate new UV spectrophotometric baseline manipulation methodology for simultaneous determination of drotaverine (DRT) etoricoxib (ETR) in a combined tablet dosage form has been developed.The method is based on (difference) spectroscopy where the amplitudes at 274 351 nm were selected to determine ETR DRT, respectively, formulation methanol was used as solvent. Both drugs obey Beer's law concentration ranges 4-20 μg/mL DRT 4.5-22.5 ETR.The results...

Background: A successful attempt has been done to develop and validate a simple stability indicating HPTLC method for the estimation of Mometasone furoate (MF) its degradation product in presence Salicylic acid (SA). The was isolated, characterized tested cytotoxicity. Introduction: is chemically 9,21-Dichloro-17α-[(2-furanylcarbonyl) oxy]- 11β-hydroxy-16-α-methylpregna-1,4-diene-3,20-dione, high potency glucocorticoid. (SA) antiseptic, antifungal keratolytic properties. Combination MF SA...

Factorial design tool applied for development of isocratic reversed-phase stability-indicating HPLC method the analysis mycophenolate mofetil (MMF) and its degradation products. MMF stress products acid (MPA) DP3 (USP impurity H) were isolated used quantitation. Separation achieved on a Symmetry C18 (250 mm × 4.6 mm, 5.0 μ ) column using methanol: acetate buffer (75 : 25 v/v), pH 6.0 (adjusted with acetic acid), at 0.5 mL flow rate, maintained 55°C, data integrated 251 nm. is subjected to...

Summary This article describes a new, simple, precise and accurate TLC method for simultaneous quantitation of atorvastatin (ATO), ezetimibe (EZE), fenofibrate (FEN) as the bulk drug in tablet dosage forms. Chromatographic separation drugs was performed on aluminum plates precoated with silica gel 60 F254 stationary phase solvent system consisting chloroform-toluene-methanol-acetic acid 6:3:0.5:0.15 (υ/υ/υ/υ). Densitometric evaluation separated zones at 263 nm. The were satisfactorily...