Capsicum annuum L. fruits, renowned for their nutritional and medicinal value, were explored as a source of valuable compounds. A method involving saponification, extraction, column chromatography was utilized to isolate two significant compounds, β-sitosterol β-citraurin, from paprika oleoresin. These known distinct properties, identified through nuclear magnetic resonance, mass spectrometry, chromatographic techniques. The newly developed proved be efficient, with reduced elution times,...

Pharmaceuticsrepeated administrations of high doses to maintain effective plasma concentrations, thus reducing patient compliance and/or enhancing the incidence side-effects.Side effects and need for administration, twice or thrice a day when larger are required, can decrease compliance.Sustained release (SR) formulation that would levels drug eight twelve hours might be sufficient once daily dosing metformin.Administration sustained-release, oncea-day metformin dosage form could reduce...

Extracts obtained from the leaves of various Alocasia species have been used in India as folk remedy for treatment inflammatory ailments including rheumatism and bruise. The ethanolic extract indica Schott. was evaluated by using different vitro antioxidant models screening like scavenging 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical, nitric oxide superoxide anion hydroxyl radical. antinociceptive activity tested acetic acid-induced writhing response, hot plate method, tail flick method...

An accurate, specific and precise assay level gradient reverse-phase high-performance liquid chromatographic method was developed for simultaneous determination of montelukast sodium bambuterol hydrochloride in tablet dosage form. inertsil ODS C-18, 5 mum column having 250x4.6 mm I.D. mode, with mobile phase A, containing 0.025 M phosphate buffer: methanol (85:15) B, acetonitrile:methanol used at different time intervals. The flow rate 1.5 ml/min effluent monitored 218 nm. retention times...

Nasal route had shown better systemic bioavailability due to its large surface area, porous endothelial membrane, high total blood flow, and avoidance of first-pass metabolism. Timolol maleate is a beta blocker used primarily in the treatment hypertension. Drug undergoes extensive hepatic metabolism (80%). The drug has half-life 4 hrs. Oral timolol 61%. aim present study was optimize controlled release situ nasal delivery for maleate. HPMC Poloxamer 407 were selected as polymer formulation...

Two methods for the simultaneous determination of Emtricitabine and Tenofovir by spectroscopy have been developed.These two simple, accurate precise include Area Under Curve (AUC) method Dual Wavelength Method.From a solvent effect studies spectral behaviours Tenofovir, methanol was selected as solvent.Emtricitabine shows maximum absorbance at 281 nm 259 nm.For AUC method, wavelength ranges between 242-248 269-275 were with reference to curves plotted wavelengths 200-400 nm.In second...

Metformin Hydrochloride (MF) is glucose lowering agent that widely used for management type II diabetes. MF reported to be absorbed mainly in upper part of GIT. It having narrow absorption window and high water solubility, it would more beneficial retain the drug stomach prolonged duration so as achieve maximum better bioavailability. A conventional oral CR formulation releases most content at colon, which requires will from colon. The present investigation aimed develop novel...

Seventeen (E)-1-(8-hydroxyquinolin-7-yl)-3-phenylprop-2-en-1 one derivatives were synthesized via aldol condensation of substituted benzaldehydes with quinoline chalcones starting from 8-hydroxy quinoline. Molecular docking studies performed on COX-2 protein for analgesic activity and PDE 4 enzyme anti-asthmatic activity. Docking reveal that the compounds 2, 4, 12, 14, 15 showed significant interaction in terms hydrogen bonding, hydrophobic attachment van der Waal COX-2. The pharmacological...

The purpose of this research was to formulate and characterize solid dispersion (SD) metformin hydrochloride using methocel K100M as the carrier by solvent evaporation cogrinding method. influence drug polymer ratio on release studied dissolution tests. Characterization performed fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calorimetry X-ray powder diffractometry. optimized formulation subjected accelerated stability testing per ICH guidelines. Release data were...

Diltiazem hydrochloride is a calcium channel blocker generally indicated for the treatment of angina and hypertension, it extensively metabolized due to hepatic metabolism. Formulation diltiazem into an oro-dispersible dosage form can provide fast relief with higher bioavailability. The bitter taste drug should be masked formulate in palatable form. In present work, attempt was made mask by complexation technique, formulation form, using superdisintegrants Doshion P544, crospovidone (CP)...

The main objective of the study was to enhance dissolution nifedipine, a poorly water soluble drug by betacyclodextrin complexation and effect preparation method on in vitro profile. stoichiometric ratio determined phase solubility analysis for inclusion nifedipine with β-cyclodextrin 1:1. Binary complex prepared different methods further characterized using XRD, DSC FT-IR. A saturation carried out evaluate increase nifedipine. optimized formulated into fast-dissolving tablets...

Metoprolol succinate (MS) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading improved drug bioavailability. Box-Behnken model followed using novel combinations of sodium alginate (SA), carboxymethylcellulose (NaCMC), magnesium alumino metasilicate (MAS) as independent variables. Floating lag (Flag), t25, t50, t75, diffusion exponent dependent variables revealed that the amount SA, NaCMC and MAS have a significant effect (p < 0.05) on t75...

The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems bisoprolol. Floating concept applied increase gastric residence dosage form having lag phase followed by a burst release. prepared system consisted two parts: core tablet containing active ingredient an erodible outer shell with gas generating agent. rapid release (RRCT) using superdisintegrants ingredient. Press coating optimized RRCT done polymer. A 3² full factorial used...

The objective of this research was to prepare, characterize and study dissolution properties inclusion complexes telmisartan (TLM), with β-cyclodextrin hydroxypropyl-β-cyclodextrin its effect on rate dissolution. phase solubility curve classified as an AP type for both the CD's, which indicated formation complex TLM in 1:2 stoichiometries β-CD HP-β-CD.

The aim of the present study was to apply design experiment (DOE) optimize floating drug delivery tapentadol hydrochloride. Tapentadol hydrochloride is a synthetic opioid used as centrally acting analgesic and effective in both experimental clinical pain. half-life about 4 hours oral dose 50 250 mg twice day. For optimization 3 2 full factorial employed for formulation tablets. Sodium bicarbonate incorporated gas-generating agent. Combination polymers Xanthan gum Locust bean achieve...