A5026536650- Veterinary Equine Medical Research
- Monoclonal and Polyclonal Antibodies Research
- Veterinary Oncology Research
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Hematological disorders and diagnostics
- Asthma and respiratory diseases
- Antimicrobial Peptides and Activities
- Microbial infections and disease research
- Reproductive Physiology in Livestock
- Ruminant Nutrition and Digestive Physiology
- Mosquito-borne diseases and control
- T-cell and B-cell Immunology
- Blood disorders and treatments
- Blood groups and transfusion
- Veterinary Orthopedics and Neurology
- Teratomas and Epidermoid Cysts
- Erythrocyte Function and Pathophysiology
- Agriculture and Farm Safety
- Tumors and Oncological Cases
- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Xenotransplantation and immune response
- Neonatal and Maternal Infections
University of Guelph
2019-2024
Murdoch University
2015-2018
Severe equine asthma (SEA) is a common, debilitating lower airway inflammatory disorder of older horses. Alveolar macrophages (AMs) survey inhaled particulates from barn sources causing them to switch an anti-inflammatory proinflammatory phenotype, resulting in neutrophil recruitment the lung. This may contribute development and prolongation SEA. Validated antibodies identify cells involved pathogenesis SEA are lacking. In this study, monoclonal against CD90, CD163, CD206 were tested for...
Alveolar macrophages (AMs) are the predominant innate immune cell in distal respiratory tract. During inflammatory responses, AMs may be supplemented by blood monocytes, which differentiate into monocyte-derived (MDMs). Macrophages play important roles a variety of common equine lower airway diseases, including severe asthma (SEA). In an experimental model, inhaled mixture Aspergillus fumigatus spores, lipopolysaccharide, and silica microspheres (FLS), induced SEA exacerbation susceptible...
Canine vector-borne diseases have a worldwide distribution, but to the best of our knowledge, no research has been carried out evaluate their presence on Indian Ocean island Mauritius. An investigation into canine infections was conducted in dogs (n = 78) resident at an animal shelter Port Louis, Mauritius using combination traditional microscopy and serological methods.Ticks were manually collected from stray dog population for identification as well quantifying tick burdens. Blood also...
The Salivary Scavenger and Agglutinin (SALSA) protein is an innate immune with various alleged functions, including the regulation of inflammation tissue remodeling. Transcriptomic studies severe equine asthma (SEA) showed downregulation gene encoding SALSA in bronchial epithelium asthmatic compared to non-asthmatic horses. This study aimed characterize expression tissues by immunohistochemistry (IHC), corroborate potential differences epithelial between horses, assess structure SALSA. An...
Horses with severe equine asthma (SEA), also known as heaves and recurrent airway obstruction, have persistent neutrophilic inflammation of the lower airways. Cytologic evaluation bronchoalveolar lavage (BAL) fluid is commonly used to confirm clinical diagnosis SEA. However, utility microscopic assessment bronchial brushings, endobronchial biopsies, immunohistochemical detection disease-associated biomarkers for SEA remain poorly characterized. Salivary scavenger agglutinin (SALSA) has...
Abstract Background Lymphocytic neoplasms with frequent reactive lymphocytes are uncommonly reported in dogs, and can pose a diagnostic challenge. Different modalities such as cytology, flow cytometry, histopathology, immunohistochemistry, clonality testing, sometimes required for diagnosis. This report illustrates the value of using multi-modal approach to decipher complex lymphocytic tumor, introduces immune repertoire sequencing adjunct. Case presentation A 10-month-old Great Dane was...
Salivary scavenger and agglutinin (SALSA) is a secreted protein with various immunomodulatory roles. In humans, the agglutinates inactivates microorganisms, inhibits release of pro-inflammatory cytokines. Saliva, which rich in SALSA, accelerates bacterial phagocytosis, but SALSA’s contribution unclear. horses, functions SALSA inflammation remain undetermined, so they were investigated through phagocytosis cytokine assays. Equine was purified from duodenal tissue, contains abundant SALSA. To...
In collaboration with the American College of Veterinary Pathologists.