A5057528164- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Ion channel regulation and function
- Epilepsy research and treatment
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neurotransmitter Receptor Influence on Behavior
Shanghai Jiao Tong University
2025
Ruijin Hospital
2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2024
Universidad Nacional de La Plata
2019-2022
Instituto Multidisciplinario de Biología Celular
2017-2021
Comisión de Investigaciones Científicas
2017
The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 (D2R). A key target of GHSR neurons is voltage-gated calcium channels type 2.2 (Ca V 2.2). Recently, liver-expressed antimicrobial peptide (LEAP2) was recognized a novel ligand, mechanism action LEAP2 on not well understood. Here, we investigated...
Voltage-gated calcium channels type 2.2 (CaV2.2) are activated by action potentials at presynaptic terminals, and their current induces neurotransmitter release. In this context, regulating CaV2.2 is critical, one of the most important mechanisms for doing so through its G protein-coupled receptor (GPCR) activity. Two such GPCRs ghrelin (GHSR) dopamine 2 (D2R) receptors. We previously demonstrated that constitutive GHSR activity reduces forward trafficking ghrelin-induced inhibits currents....
Abstract The loss of consciousness (LOC) during seizures is one the most striking features that significantly impact quality life, even though neuronal network involved not fully comprehended. We analyzed intracerebral patterns in patients with focal drug-resistant epilepsy, both and without LOC. assessed localization, lateralization, stereo electroencephalography (SEEG) patterns, seizure duration, quantification contacts exhibiting electrical discharge. degree LOC was quantified using...
Background and Purpose Ca V 3.1‐3 currents differentially contribute to neuronal firing patterns. 3 are regulated by G protein‐coupled receptors (GPCRs) activity, but information about as targets of the constitutive activity GPCRs is scarce. We investigate impact D 5 recpetor a GPCR with high levels basal on functionality. expressed in hippocampus have been independently linked pathophysiological states associated epilepsy. Experimental Approach Our study models were HEK293T cells...