A5082274274- Fluorine in Organic Chemistry
- Ionic liquids properties and applications
- Chemical Synthesis and Reactions
- Plant biochemistry and biosynthesis
- Inorganic Fluorides and Related Compounds
- Microbial Natural Products and Biosynthesis
- Protein Structure and Dynamics
- Synthesis and Biological Evaluation
- Oxidative Organic Chemistry Reactions
- Alzheimer's disease research and treatments
- Synthesis and Catalytic Reactions
- Lipid Membrane Structure and Behavior
- Enzyme Structure and Function
- Synthesis and biological activity
- Supramolecular Self-Assembly in Materials
- Metal-Catalyzed Oxygenation Mechanisms
- Graphene and Nanomaterials Applications
- Click Chemistry and Applications
- Phytochemistry and Bioactivity Studies
- Pharmacological Effects of Natural Compounds
- Chemical Synthesis and Analysis
- Medical Imaging Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Sulfur-Based Synthesis Techniques
- RNA modifications and cancer
Institute of Chemical Technology
2021-2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2022
Smt. Kashibai Navale Medical College and General hospital
2022
National Chemical Laboratory
2004-2021
Jawaharlal Nehru Medical College
2021
Datta Meghe Institute of Medical Sciences
2021
Academy of Scientific and Innovative Research
2019
Hokkaido University
2012-2018
Kyung Hee University
2017
Council of Scientific and Industrial Research
2016
We examined the antibacterial activities of nanosheets graphene analogue tungsten disulphide (WS<sub>2</sub>) and a composite reduced oxide-tungsten (rGO-WS<sub>2</sub>).
We have demonstrated the synergistic effect in nucleophilic fluorination when we combined two solvents--ionic liquid (IL) and tert-alcohol--into one molecule. Consequently, these functionalized ILs not only increase reactivities of fluoride anion but also remarkably reduce olefin byproduct. Although mechanism this remains to be elucidated, illustrated possibility solvent engineering for a specific reaction.
Enantioselective epoxidation followed by regioselective epoxide opening reaction are the key processes in construction of polyether skeleton. Recent genetic analysis ionophore biosynthetic gene clusters suggested that flavin-containing monooxygenases (FMOs) could be involved oxidation steps. In vivo and vitro analyses Lsd18, an FMO biosynthesis lasalocid, using simple olefin or truncated diene a putative substrate as mimics demonstrated enantioselective affords natural type mono- bis-epoxide...
Longestin (KS-505a), a specific inhibitor of phosphodiesterase, is meroterpenoid that consists unique octacyclic terpene skeleton with branched methyl groups at unusual positions (C1 and C12). Biochemical analysis Lon23, methyltransferase involved in the biosynthesis longestin, demonstrated it methylates homoisopentenyl diphosphate (homo-IPP) to afford (3Z)-3-methyl IPP. This compound, along IPP, selectively accepted as extender units by Lon22, geranylgeranyl (GGPP) synthase homologue, yield...
Abstract A general method for immobilization of synthetic analogues the [FeFe]‐hydrogenase in designed peptides via on resin modification an amino acid side chain with a dithiol functional group is described. Utilizing unique amine as anchor, unit coupled to peptide formation amide. This precisely positions two required sulfur atoms [(μ‐SRS){Fe(CO) 3 } 2 ] cluster reaction [Fe (CO) 12 ]. UV/Vis and FTIR spectroscopy demonstrate desired complex.
Proteins and peptides fold into dynamic structures that access a broad functional landscape; however, designing artificial polypeptide systems is still great challenge. Conversely, DNA engineering now routinely used to build wide variety of 2D 3D nanostructures from hybridization based rules, their diversity can be significantly expanded through site specific incorporation the appropriate guest molecules. Here we demonstrate new approach rationally design nucleic acid–amino acid complexes...
The tert-alcohol and ionic liquid solvents in one molecule [mim-(t)OH][OMs] was immobilized on polystyrene reported to be a highly efficient catalyst aliphatic nucleophilic substitution using alkali metal salts. Herein, we investigated the catalytic activity of new structurally modified polymer-supported functionalized imidazolium salt 2-(3-methanesulfonyloxypropyoxy)naphthalene as model substrate with various nucleophiles. moiety hexyl chain distance from had better compared other resin...
An ionic liquid bearing <italic>tert</italic>-butanol moiety ([mim-<sup>t</sup>OH][OMs]) was employed as catalyst in the nucleophilic fluorination of 2-(3-bromopropyloxy)-naphthalene using alkali metal fluorides.
The<italic>tert</italic>-BuOH functionalized and dodecyl alkyl chain bearing imidazolium ionic liquid [C<sub>12</sub>-<sup>t</sup>OHim][OMs] significantly prevented biofilm formation of<italic>S. epidermidis</italic>and showed potential antimicrobial activity.
Currently no structurally sensitive spectroscopic techniques are capable of co-determining ensemble structural content and localized lipid versus aqueous solvation information. Here, we describe the first deep-UV (λex<210 nm) resonance Raman (dUVRR) spectra a model α-helical peptide embedded in membrane-mimetic environment, confirming sensitivity to secondary structure revealing dUVRR backbone. Detailed facts importance specialist readers published as ”Supporting Information”. Such documents...
Abstract Tri‐ tert ‐butanol amine acts as promoter with alkali metal salts in the nucleophilic fluorination of alkylsulfonates. It significantly enhances reactivity minimum formation side‐products (alkene, ether, and alcohol) compared to other catalysts reaction. The synergism ‐alcohol moiety plays a pivotal role fluorination.
The design of binding sites for divalent metals in artificial proteins is a productive platform examining the characteristics metal-ligand interactions. In this report, we investigate spectroscopic properties small peptides and four-helix bundles that bind Cu(II). Three peptides, consisting 15 amino acid residues, were designed to have two arms, each containing metal-binding site comprised different combinations imidazole carboxylate side chains. Two had central dinuclear metal cofactor,...
An efficient and green procedure for the synthesis of raloxifene has been developed by using Suzuki couplings, Friedel-Crafts acylation, copper catalyzed coupling reactions in an ionic liquid. Keywords: Raloxifene, liquids, coupling, acylation