A5049363259- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Tuberculosis Research and Epidemiology
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Synthesis of β-Lactam Compounds
- Curcumin's Biomedical Applications
- Nanoparticles: synthesis and applications
- Synthesis of Tetrazole Derivatives
- Synthesis and Reactions of Organic Compounds
- Ubiquitin and proteasome pathways
- Antimicrobial Peptides and Activities
- Plant-derived Lignans Synthesis and Bioactivity
- Supramolecular Self-Assembly in Materials
- Galectins and Cancer Biology
- Piperaceae Chemical and Biological Studies
- Protein Degradation and Inhibitors
- Essential Oils and Antimicrobial Activity
- Bacteriophages and microbial interactions
- Silk-based biomaterials and applications
National Chemical Laboratory
2015-2021
Korea Research Institute of Bioscience and Biotechnology
2021
Korea University of Science and Technology
2021
Hallym University
2018
Savitribai Phule Pune University
2015-2016
A library of thirty one 1,2,3-triazole derivatives efficiently prepared<italic>via</italic>click chemistry and evaluated for their antitubercular, antioxidant, cytotoxic activities.
Purpose: Multi- and extensively drug-resistant tuberculosis (TB) is a global threat to human health. It requires immediate action seek new antitubercular compounds devise alternate strategies. Nanomaterials, in the present scenario, have opened avenues medicine, diagnosis, therapeutics. In view of this, current study aims determine efficacy phytogenic metal nanoparticles inhibit mycobacteria. Methods: Silver (AgNPs), gold (AuNPs), gold–silver bimetallic (Au–AgNPs) synthesized from medicinal...
A library of 1,2,3‐triazoles efficiently prepared via click chemistry and evaluated for their antifungal, antitubercular, antioxidant, cytotoxicity, molecular docking ADME prediction.
N-terminal arginylation (Nt-arginylation) serves as a protein degradation signal in both the ubiquitin-proteasome system and autophagy-lysosomal pathway. However, scarcity of arginylated proteins cells limitations current identification methods have hindered progress this field. In study, we developed novel integrated approach that combines N-terminomics (N-terminomic enrichment, LC-MS/MS, tandem database search) with advanced machine learning-based filtering strategies to successfully...
Sophorolipids (SLs) are glycolipid biosurfactants that have been shown to display anticancer activity. In the present study, we report anti-proliferative studies on purified forms of novel SLs synthesized using cetyl alcohol as substrate (referred SLCA) and their mechanism in human cervical cancer cells. Antiproliferative effect column SLCA fractions (A, B, C, D, E F) was examined panel cell lines well primary Among these fractions, B C significantly inhibited survival HeLa HCT 116 cells...
Resistance among dormant mycobacteria leading to multidrug-resistant and extremely drug-resistant tuberculosis is one of the major threats. Hence, a series 1,2,4-triazole-3-thione 1,3,4-oxadiazole-2-thione derivatives (4a-5c) have been synthesized screened for their antitubercular activity against Mycobacterium H37Ra (H37Ra). The triazolethiones 4b 4v showed high (both MIC IC50 ) by in vitro ex vivo. They were shown more specificity toward than other Gram-negative Gram-positive pathogenic...
The antiproliferative activity of two chito-specific agglutinins purified from Benincasa hispida (BhL) and Datura innoxia (DiL9) different plant family origin was investigated on various cancer cell lines. Both lectins showed chitotriose specificity, by inhibiting lectin hemagglutinating activity. On further studies, it revealed that these caused remarkable concentration-dependent effect human pancreatic cancerous cells but not the normal umbilical vein endothelial even at higher doses...
In a search of new potentially active antitubercular agents here we have synthesized 3-substituted phenyl-2-(4-(tetrazolo[1,5-a]quinolin-4-ylmethoxy)phenyl)thiazolidin-4-ones (8a-l) and evaluated their antibacterial, particularly activity. These been conveniently by performing one-pot cyclocondensation 4-(tetrazolo[1,5-a]quinolin-4-ylmethoxy)benzaldehyde, anilines mercaptoacetic acid in dicationic ionic liquid, (3-methyl-1-[3-(methyl-1H-imidazolium-1-yl)propyl]-1H-imidazolium dibromide...
Synthesis of new tetrazoloquinoline–thiazolidinone conjugates were achieved<italic>via</italic>one-pot three-component cyclocondensation in the presence [DBUH][OAc] and studied antitubercular activity.
Faster gelation of silk fibroin using biosurfactants: sophorolipid, towards 3D scaffolds for biomedical application.
A series of pyridine clubbed 1,3,4-oxadiazole derivatives were efficiently synthesized, characterized by standard spectral techniques and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis (MTB) H37Ra bovis BCG active dormant state using an established methods. Compounds 5a, 5m, 5t identified as the most compounds MTB. Molecular docking was performed MTB enoyl-ACP (CoA) reductase (FabI/ENR/InhA) enzyme to predict binding modes affinity. The theoretical...
Mesoporous silica nanoparticles (MSNs) with ordered pore structure have been synthesized and used as carriers for the anticancer drug curcumin. MSNs were functionalized amine groups further attached carboxymethyl cellulose (CMC) using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) coupling chemistry, which increased hydrophilicity biocompatibility of MSNs. The (MSN-NH₂ MSN-CMC) characterized Scanning Electron Microscopy (SEM), Transmission (TEM), Dynamic Light Scattering (DLS), N₂...