A5078432793- Enzyme Catalysis and Immobilization
- Microbial bioremediation and biosurfactants
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Structure and Function
- Enzyme Production and Characterization
- Gold and Silver Nanoparticles Synthesis and Applications
- Biochemical and Molecular Research
- Nanoparticles: synthesis and applications
- Silk-based biomaterials and applications
- Biofuel production and bioconversion
- Bacterial biofilms and quorum sensing
- Quantum Dots Synthesis And Properties
- Protein purification and stability
- Mesoporous Materials and Catalysis
- Biochemical and Structural Characterization
- Advanced Nanomaterials in Catalysis
- Curcumin's Biomedical Applications
- Electrochemical sensors and biosensors
- Polymer Surface Interaction Studies
- Antibiotic Resistance in Bacteria
- Antimicrobial Peptides and Activities
- Porphyrin and Phthalocyanine Chemistry
- Microbial Metabolism and Applications
- Toxic Organic Pollutants Impact
- Nanoparticle-Based Drug Delivery
National Chemical Laboratory
2012-2024
Academy of Scientific and Innovative Research
2016-2021
Biotech Park
2020-2021
Google (United States)
2018
Council of Scientific and Industrial Research
2013-2015
Savitribai Phule Pune University
2015
Nottingham Trent University
2012
University of South Florida
2009
University of Hull
2000-2002
Covalent organic nanosheets (CONs) have emerged as functional two-dimensional materials for versatile applications. Although π–π stacking between layers, hydrolytic instability, possible restacking prevents their exfoliation on to few thin layered CONs from crystalline porous polymers. We anticipated rational designing of a structure by intrinsic ionic linker could be the solution produce self-exfoliated without external stimuli. In an attempt address this issue, we synthesized three...
We report a one-pot synthesis of spherical gold nanoparticles (52–22 nm) and their capping with cefaclor, second-generation antibiotic, without use other chemicals. The differently sized were fabricated by controlling the rate reduction ions in aqueous solution varying reaction temperature (20–70 °C). primary amine group cefaclor acted as both reducing agent for leaving β-lactam ring available activity against microbes. Antimicrobial testing showed that reduced have potent antimicrobial...
Sophorolipids (SLs), biosurfactants with antimicrobial properties, have been tried to address the problem of antibiotic resistance. The synergistic action SL and antibiotics was checked using standard microdilution spread plate methods. With Staphylococcus aureus , SL-tetracycline combination achieved total inhibition before 4 h exposure while tetracycline alone couldnot achieve till end 6 h. caused by bacterium mixture ~ 25% more as compared alone. In spite known robustness gram-negative...
Bile salt hydrolase (BSH) is an enzyme produced by the intestinal microflora that catalyzes deconjugation of glycine- or taurine-linked bile salts. The crystal structure BSH reported here from Bifidobacterium longum reveals it a member N-terminal nucleophil structural superfamily possessing characteristic alphabetabetaalpha tetra-lamellar tertiary arrangement. Site-directed mutagenesis catalytic residue, however, shows has no role in zymogen processing into its corresponding active form....
The production of a new class glycolipid–metal nanoparticle conjugates, namely, sophorolipid reduced/capped silver nanoparticles is demonstrated for the first time, by unveiling reducing and capping abilities derived from oleic acid. It also that capped Ag are highly potent antibacterial agents, against both Gram-positive Gram-negative bacteria. utilization brings out several advantages, such as eliminating necessity exogenous agent imparting better stability to compared their acid...
Co-sonication of curcumin and acidic sophorolipid in aqueous solution is shown to lead a dramatic enhancement bioavailability through size reduction encapsulation.
A systematic cytotoxic and genotoxic evaluation of glycolipid-conjugated silver gold nanoparticles is carried out. These glycolipid nanoparticle conjugates are obtained by exploiting the reductive capability a class glycolipids called sophorolipids that play role capping agent as well. Further, when tested for their cytotoxicity genotoxicity on HepG2 cells, these found to be cytocompatible up 100 μM metal concentrations. Of two metallic systems investigated, more than same concentrations...
Biocompatible gold nanoparticles were synthesized by using a naturally occurring gum--Gellan Gum--as capping and reducing agent. These further conjugated with sophorolipids which again accessed through biochemical transformation of fatty acid. The cellular uptake sophorolipid-conjugated gellan gum reduced their cytotoxicity on human glioma cell line LN-229 stem HNGC-2 investigated. Quite surprisingly even the simple reduced/capped showed greater efficacy in killing lines and, gratifyingly,...
Sophorolipids are a class of glycolipids that can be obtained from fatty acids by simply treating them with yeast cells (Candida bombicola, ATCC 22214) and glucose. In this letter, we demonstrate the application sophorolipids oleic acid as capping agent for Co nanoparticles. Upon nanoparticle surface, sugar moiety these is exposed to solvent environment, making nanoparticles stable water-redispersible.
Sophorolipids (SLs) are glycolipidic biosurfactants suitable for various biological and physicochemical applications. The nonedible Jatropha oil has been checked as the alternative raw material SL synthesis using C. bombicola (ATCC22214). This is useful towards lowering production cost. Through optimization of fermentation parameters use resting cell method, yield 15.25 g/L could be achieved derived (SLJO) with 1% v/v feeding. synthesized displayed good surfactant property. It reduced...
Ag<sup>0</sup>nanoparticles were synthesized by<italic>Lantana camara</italic>plant (weed) leave extract. Antibacterial activity of the as was excellent against both Gram −ve and +ve bacterial culture.
Silver nanoparticles were synthesized by continuous flow methods using biosurfactants, namely, oleic acid sophorolipid (OASL) and stearic (SASL). Both the sophorolipids can act as reducing capping agents. The effect of temperature on completion nanoparticle formation particle growth dynamics (size) studied in batch mode. While reaction needed 20 min, only 5 min required with agent. Hence all experiments carried out sophorolipid. synthesis silver was a stainless steel helical coil also spiral...
Abstract In recent years, researchers have developed biosurfactants for industrial, pharmaceutical and medical applications revealing the promising biological activities of these biomolecules. One best studied microbial surfactants are glycolipids, especially sophorolipids (SLs) produced by selected non‐pathogenic yeast species Candida . They biodegradable, non‐toxic environmentally friendly. Sophorolipid production was carried out using glucose as hydrophilic source lauryl alcohol C 12–14 ,...
Essential oils (EOs) form an important part of traditional medicine so their anti-microbial and, in the recent past, antiquorum sensing activity has been well studied. However it is likely that due to hydrophobic nature and reduced solubility aqueous environments full potential cannot be realized. hence only rational formulate a process make these molecules more polar nature. The present paper reports synthesis sophorolipids using 12 different essential as substrates, thus providing...