A5023103558- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Quinazolinone synthesis and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
Bhavnagar University
2017-2020
A series of pyridine clubbed 1,3,4-oxadiazole derivatives were efficiently synthesized, characterized by standard spectral techniques and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis (MTB) H37Ra bovis BCG active dormant state using an established methods. Compounds 5a, 5m, 5t identified as the most compounds MTB. Molecular docking was performed MTB enoyl-ACP (CoA) reductase (FabI/ENR/InhA) enzyme to predict binding modes affinity. The theoretical...
We have prepared 15 hybrid pyrazole, pyrazoline‐clubbed pyridine–containing compounds (5a‐o) and tested for their antibacterial antifungal activities the development of potential antimicrobial agents. The structures this novel series were characterized by various spectral techniques like IR, 1 H NMR, 13 C LC–MS, elemental analysis. synthesized 5d, 5e, 5i, 5k, 5m, 5o exhibited significant activity in comparison standard drugs. Molecular docking studies that been carried out to emphasize...
Introduction: In continuation of our efforts to find new antimicrobials, herein we report the synthesis various pyrazole, pyrazoline, and pyridine based novel bioactive heterocycles (3a-t). Methods: Newly synthesized compounds were analysed for their antimicrobial activity. Compounds 3c, 3h, 3i, 3k, 3n, 3q showed significant Results: Molecular docking study most active analogues against DNA gyrase subunit b (PDB ID: 1KZN) corroborated well with observed potency exhibiting binding affinity....
A series of novel compounds 1-((1-(4-(2H-benzo[e][1,3]oxazin-3(4H)-yl)phenyl)ethylidene)amino)-6-((benzylidene)amino)-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles (7a–o) were synthesized by a sequence multistep reactions. IR, 1H NMR, 13C and mass spectral techniques used to confirm the structures newly compounds. Antimicrobial activity title was studied against strains bacteria (Staphylococcus aureus Streptococcus pyogenes, Escherichia coli Pseudomonas aeruginosa) fungi (Candida...
We have synthesized novel series of N-(1-(2-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)ethylidene)arylaniline and their derivatives. The structures compounds were well characterized by spectroscopic techniques. Antimicrobial activity the newly derivatives was evaluated against gram positive (S. aureus S. pyogenes), negative bacteria (E. coli P. aeruginosa), strains fungi (C. albicans, A. niger clavatus). Among screened 5c, 5f, 5i, 5l 5t demonstrated...
We have synthesized novel series of N-(1-(2-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)ethylidene)arylaniline and their derivatives. The structures compounds were well characterized by spectroscopic techniques. Antimicrobial activity the newly derivatives was evaluated against gram positive (S. aureus S. pyogenes), negative bacteria (E. coli P. aeruginosa), strains fungi (C. albicans, A. niger clavatus). Among screened 5c, 5f, 5i, 5l 5t demonstrated...