A5101617300- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- GABA and Rice Research
- Plant Molecular Biology Research
- Chronic Myeloid Leukemia Treatments
- Plant nutrient uptake and metabolism
- Plant Micronutrient Interactions and Effects
- Plant Stress Responses and Tolerance
- Plant tissue culture and regeneration
- Computational Drug Discovery Methods
- Genetic Mapping and Diversity in Plants and Animals
- Neurological Complications and Syndromes
- Agricultural Practices and Plant Genetics
- Plant Virus Research Studies
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Synthesis and biological activity
- Rice Cultivation and Yield Improvement
- Plant Disease Resistance and Genetics
- HER2/EGFR in Cancer Research
- Lipid metabolism and biosynthesis
- Neuroscience of respiration and sleep
- Plant Genetic and Mutation Studies
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
Punjabi University
2024-2025
Institute of Microbial Technology
2024
SciGenom Labs (India)
2019-2023
Indian Institute of Information Technology Allahabad
2015-2023
Nanaji Deshmukh Veterinary Science University
2022
Sam Higginbottom Institute of Agriculture
2017
International Crops Research Institute for the Semi-Arid Tropics
2017
Indian Agricultural Statistics Research Institute
2015
Glostrup Hospital
2009-2012
University of Copenhagen
2009-2012
Pearl millet [Cenchrus americanus (L.) Morrone] is a staple food for more than 90 million farmers in arid and semi-arid regions of sub-Saharan Africa, India South Asia. We report the ∼1.79 Gb draft whole genome sequence reference genotype Tift 23D2B1-P1-P5, which contains an estimated 38,579 genes. highlight substantial enrichment wax biosynthesis genes, may contribute to heat drought tolerance this crop. resequenced analyzed 994 pearl lines, enabling insights into population structure,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for the current global pandemic that caused a death toll of >1.12 million worldwide and number continues to climb in several countries. Currently, there are neither specific antiviral drugs nor vaccines treatment prevention COVID-19. We screened
Natural products acquire massive structural and chemical diversity, which cannot be coordinated by any synthetic libraries for small molecules they are continuing to inspire novel discoveries in health sciences. We have performed the computational calculations geometry optimization prediction of electronic properties some plant phenolic compounds through Gaussian 09 program. Energies molecular orbitals were computed, mimic out stabilities arising from charge delocalization intramolecular...
Background: and aim Glyceryl trinitrate (GTN) infusion is a reliable method to provoke migraine-like headaches in humans. Previous studies have simulated this human model anaesthetized or awake rodents using GTN doses 10,000 times higher than used The relevance of such toxicological migraine not certain. Anaesthesia low blood pressure caused by high both can affect the expression nociceptive marker c-fos. Therefore, our was simulate rats clinically relevant dose. Methods: Awake were infused...
Background NXN-188 is a combined neuronal nitric oxide synthase (nNOS) inhibitor and 5-hydroxytryptamine 1B/1D (5-HT ) receptor agonist. Using preclinical models, we evaluated whether these two unique therapeutic principles have synergistic effect in attenuating stimulated calcitonin gene-related peptide (CGRP) release, marker of trigeminal activation. Methods We examined the on: (1) KCl-, capsaicin- resiniferatoxin (RTX)-induced immunoreactive CGRP (iCGRP) release from isolated preparation...
Deficiency of necessary macronutrients, i.e., Potassium (K), Magnesium (Mg), Nitrogen (N), Phosphorus (P), and Sulfate (S) in the soil leads to a reduction plant growth yield, which is result changes expression level various genes. This study was performed identify differentially expressed genes its associated metabolic pathways occurred grown wheat root samples excavated from control treated fields. To difference gene levels due deficiency said nutrients, transcriptomic, meta-analysis on...
Protein phosphorylation is an important mechanism that implicates in physiology of any organism including parasitic protozoa. Metallic protein Ser/Thr phosphatase 5 (PP5) controls various cellular signaling pathways Plasmodium falciparum. The structure and inhibitory PP5 P. falciparum not known. In fact, no experimental structural data are available for (PfPP5) till date. Hence, we have proposed computer-generated model catalytic subunit PfPP5 its was analyzed. A set 42 known natural...
ADP-glucose pyrophosphorylase (AGPase) is a heterotetrameric enzyme with two large subunits (LS) and small (SS). It plays critical role in starch biosynthesis. We are reporting here detailed structure, function evolution of the genes encoding LS SS among monocots dicots. 'True' orthologs maize Sh2 (AGPase LS) Bt2 SS) were identified seven other three dicots; structure at protein level was also studied. Novel findings current study include following: (i) DNA level, controlling more conserved...
Background: The ATP-sensitive K + (K ATP ) channel openers levcromakalim and pinacidil are vasodilators that induce headache in healthy people. neuropeptide calcitonin gene-related peptide (CGRP) induces people migraine migraineurs, potentially through a mechanism involves opening of vascular or neuronal channels mast cell degranulation. Using rat as model, we studied the molecular presence trigeminovascular system. Furthermore, examined whether stimulate vitro release CGRP they degranulate...
Development of minerals rich grains with stress tolerance response (STR) wheat cultivars will help to eradicate malnutrition problem globally. The current study deals the comparative transcriptome analysis 4 High- and 3 Low- grain Zinc (Zn) & Iron (Fe) containing genotypes (HZFWGs, LZFWGs) elucidate genes responsible for mineral transportation mechanism response(STR). Differentially expressed (DEGs) their functional role in metabolic pathways transportation, as well other important pathways,...
Aberrant and proliferative expression of the oncogene BCR-ABL in bone marrow cells had been proven as prime cause chronic myeloid leukemia (CML). It has established that tyrosine kinase domain protein is a potential therapeutic target for treatment CML. Imatinib considered first-generation drug can inhibit enzymatic action by inhibiting ATP binding with protein. Later on, insensitivity CML towards observed may be due to mutation ABL receptor. Subsequently, some other second-generation drugs...
The human protein methyl-transferase DOT1L catalyzes the methylation of histone H3 on lysine 79 (H3K79) at homeobox genes and is also involved in a number significant processes ranging from gene expression to DNA-damage response cell cycle progression. Inhibition activity by shRNA or small-molecule inhibitors has been established prevent proliferation various MLL-rearranged leukemia cells vitro, establishing an attractive therapeutic target for mixed lineage (MLL). Most drugs currently use...
Signal transducer and activator of transcription (STAT) proteins are latent cytoplasmic factors that transduce signals from cytokines growth to the nucleus thereby regulate expression a variety target genes. Although mutations STATs have not been reported in human tumors but activity several members family, such as STAT1 STAT5, is deregulated carcinoma. STAT5 share structural similarity with highly conserved SH2 domain which responsible for activation STAT on interaction phosphotyrosine...
During migraine, trigeminal nerves may release calcitonin gene-related peptide (CGRP), inducing cranial vasodilatation and central nociception; hence, inhibition or blockade of craniovascular CGRP receptors prevent this abort migraine headache. Several preclinical studies have shown that glutamate receptor antagonists affect the pathophysiology migraine. This study investigated whether NMDA (ketamine MK801), AMPA (GYKI52466) kainate (LY466195) affected dural induced by alpha-CGRP, capsaicin...
Heat shock protein 70 (HSP70) is an important chaperone, involved in folding, refolding, translocation and complex remodeling reactions under normal as well stress conditions. However, expression of HSPA1A gene heat cold conditions associates with other chaperons perform its function. Experimental structure for Camel HSP70 (cHSP70) has not been reported so far. Hence, we constructed 3D models cHSP70 through multi- template comparative modeling HSP110 S. cerevisiae (open state) E. coli 70kDa...