A5033832107- Cystic Fibrosis Research Advances
- Gastroesophageal reflux and treatments
- Pediatric health and respiratory diseases
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Esophageal Cancer Research and Treatment
- Genomics and Rare Diseases
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Obstructive Sleep Apnea Research
- Gut microbiota and health
- Genetics and Neurodevelopmental Disorders
- Respiratory viral infections research
- Dysphagia Assessment and Management
- Gastrointestinal disorders and treatments
- Metabolomics and Mass Spectrometry Studies
- Child and Adolescent Health
- Colorectal Cancer Screening and Detection
- Diet and metabolism studies
- Patient Satisfaction in Healthcare
- Health Literacy and Information Accessibility
- Legal and Regulatory Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Seattle Children's Hospital
2024
University of Colorado Anschutz Medical Campus
2024
Lurie Children's Hospital
2019-2024
College of the Holy Cross
2015
University College Cork
2011
Duke University Hospital
2001-2005
Duke Medical Center
2001-2005
Duke University
2000-2004
Case Western Reserve University
2000
Cleveland Hearing & Speech Center
2000
<h3>Background</h3> Nocturnal gastroesophageal reflux (nGER) is common in patients with obstructive sleep apnea (OSA). Small, short-term studies have shown that treatment nasal continuous positive airway pressure (CPAP) decreases esophageal acid exposure. <h3>Objective</h3> To examine the relationship between OSA and nGER, effect of CPAP on a long-term follow-up study large cohort nGER. <h3>Methods</h3> We prospectively studied 331 diagnosed as having October 1, 1993, November 30, 2000. At...
Non-cardiac chest pain (NCCP) is a common and distressing condition. Prior studies suggest that psychotropic medication or coping skills training (CST) may benefit NCCP patients. To our knowledge, no clinical trials have examined the separate combined effects of CST in management NCCP. This randomized trial antidepressant (sertraline) participants with non-cardiac pain. A sample individuals diagnosed was randomly assigned to one four treatments: (1) plus sertraline (CST+sertraline), (2)...
Pathogenic variants in KCNB1, encoding the voltage-gated potassium channel KV 2.1, are associated with developmental and epileptic encephalopathy (DEE). Previous functional studies on a limited number of KCNB1 indicated range molecular mechanisms by which affect function, including loss voltage sensitivity, ion selectivity, reduced cell-surface expression.We evaluated series 17 DEE or other neurodevelopmental disorders (NDDs) to rapidly ascertain dysfunction using high-throughput assays....
Surveys have shown that 60 million persons in the United States searched for health information online 1998. However, lack of sampling from a clinic population limits generalizability these surveys to clinical practice.To determine gastroenterology patients' access and use Web as medical resource, identify what patients search, how often physicians recommend search Web.Cross-sectional survey 1006 outpatients Durham, NC, Rockford, Ill, conducted August 1999.Patient characteristics education...
OBJECTIVE: The reported incidence of adenocarcinoma in Barrett’s esophagus is variable. aim this study was to determine the dysplasia and a population patients with followed prospectively compare these findings other series. METHODS: All enrolled Cleveland Clinic Foundation’s registry from 1979 1995 were followed. defined as intestinal metaplasia anywhere tubular esophagus. recorded systematically. RESULTS: A total 136 (91 male, 45 female) an endoscopic surveillance program for mean 4.2 yr...
The leading cause of morbidity and mortality in cystic fibrosis (CF) is progressive lung disease secondary to chronic airway infection inflammation; however, what drives CF inflammation not well understood. By providing a physiological snapshot the airway, metabolomics can provide insight into these processes. Linking metabolomic data with microbiome phenotypic measures reveal complex relationships between metabolites, lower bacterial communities, outcomes. In this study, we characterize...
Rationale Chronic airway infection and inflammation resulting in progressive, obstructive lung disease is the leading cause of morbidity mortality cystic fibrosis. Understanding lower microbiota across ages can provide valuable insight potential therapeutic targets. Objectives To characterize compare fibrosis control subjects pediatric age spectrum. Methods Bronchoalveolar lavage fluid samples from 191 (63 with fibrosis) aged 0 to 21 years were collected along relevant clinical data. We...
Airway infection and inflammation lead to the progression of obstructive lung disease in persons with cystic fibrosis (PWCF). However, (CF) fungal communities, known drivers CF pathophysiology, remain poorly understood due shortcomings traditional culture. Our objective was apply a novel small subunit rRNA gene (SSU-rRNA) sequencing approach characterize lower airway mycobiome children without CF.Bronchoalveolar lavage fluid (BALF) samples relevant clinical data were collected from pediatric...
Airway microbiota are known to contribute lung diseases, such as cystic fibrosis (CF), but their contributions pathogenesis still unclear. To improve our understanding of host-microbe interactions, we have developed an integrated analytical and bioinformatic mass spectrometry (MS)-based metaproteomics workflow analyze clinical bronchoalveolar lavage (BAL) samples from people with airway disease. Proteins BAL cellular pellets were processed pooled together in groups categorized by disease...
BiTiSH MBT I CAL JOUWAL.9 DECEMER 1972 place much reliance on om tie infec- tion rates from difet hospitals because of differences in methods treatment and prevalent strains bacieria.Thes are by no means the only variables.We have been studying wound infections at this hospit for past two years ied out ontinuous monitorig all over a year.An initial difficulty was to define what constitutes infection.When discare
ABSTRACT We examined seizure semiology and response to medications in 28 children (9 female, 19 male) with likely pathogenic SCN2A -related epilepsy. Parents reported onset, semiology, genetic variants, therapies used for seizures, treatment. 27 experienced defined seizures 1 no history. The most common initial were focal or hemi-convulsions (n=8). Tonic the type while febrile atonic drop least common. Most patients multiple daily entirely seizure-free, difference based on age at onset....
Chronic granulomatous disease (CGD) is a group of hereditary disorders impaired intracellular destruction phagocytosed bacteria. Gastrointestinal manifestations are present, with hepatic abscess being the most common. In this case report, we present an adult CGD esophageal involvement, which has been described in only one other adult. The clinical history, modalities diagnosis (including endoscopy, barium radiography, and manometry), therapeutic strategies pertaining to discussed. A review...
We present a methodology for optimization of chromatogram alignment using class separability measure called the Hotelling trace criterion (HTC). This metric is multi‐class distance that accounts within‐class and between‐class variation. chose correlation optimized warping algorithm as our method used HTC to judge effectiveness based on parameters segment length max warp. Biodiesel feedstock samples representing classes soy, canola, tallow, waste grease, hybrid were in experiments. Fatty acid...
Abstract Motivation Longitudinal microbiome studies (LMS) are increasingly common but have analytic challenges including non-independent data requiring mixed-effects models and large amounts of that motivate exploratory analysis to identify factors related outcome variables. Although change (i.e. calculating deltas between values at different timepoints) can be powerful, how best conduct these analyses is not always clear. For example, observational LMS measurements show natural...
ABSTRACT Pathogenic variants in KCNB1 , encoding the voltage-gated potassium channel Kv2.1, are associated with developmental and epileptic encephalopathies (DEE). Previous functional studies on a limited number of indicated range molecular mechanisms by which affect function, including loss voltage sensitivity, ion selectivity, reduced cell-surface expression. We evaluated series 17 DEE or neurodevelopmental disorder (NDD) to rapidly ascertain dysfunction using high-throughput assays....